Cholecystitis

Common Name(s)

Cholecystitis

In general, gallbladder disease (GBD) is one of the major digestive diseases. GBD prevalence is particularly high in some minority populations in the United States, including Native and Mexican Americans. Gallstones composed of cholesterol (cholelithiasis) are the common manifestations of GBD in western countries, including the United States. Most people with gallstones remain asymptomatic through their lifetimes; however, it is estimated that approximately 10 to 50% of individuals eventually develop symptoms. Significant risk factors associated with GBD are age, female sex, obesity (especially central obesity), lipids, diet, parity, type 2 diabetes ({125853}), medications, and Mexican American ethnicity. GBD appears to be strongly related to the metabolic syndrome ({605552}) and/or its major components, such as hyperinsulinism, dyslipidemia, and abdominal adiposity ({2:Boland et al., 2002}; {17:Tsai et al., 2004}). Infection, specifically by Helicobacter, has been implicated in cholelithiasis and cholecystitis ({16:Silva et al., 2003}; {10:Maurer et al., 2005}). Low phospholipid-associated cholelithiasis is a specific form of gallbladder disease characterized by young-adult onset of chronic cholestasis with intrahepatic sludge and cholesterol cholelithiasis. Affected individuals have recurrence of the disorder after cholecystectomy and show a favorable response to treatment with ursodeoxycholic acid (UDCA) (summary by {11:Pasmant et al., 2012}). Mutation in the ABCB4 gene can cause a spectrum of related diseases, including the more severe progressive familial intrahepatic cholestasis-3 (PFIC3; {602347}), intrahepatic cholestasis of pregnancy-3 (ICP3; {614972}), andoral contraceptive-induced cholestasis (OCIC; see {614972}). Genetic Heterogeneity of Gallbladder Disease Two major susceptibility loci for symptomatic gallbladder disease have been identified on chromosome 1p in Mexican Americans (GBD2, {609918}; GBD3, {609919}). In addition, variations in the ABCG8 gene ({605460}) on chromosome 2p21 confer susceptibility to gallbladder disease (GBD4; {611465}).
 

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Condition Specific Organizations

Following organizations serve the condition "Cholecystitis" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cholecystitis" returned 598 free, full-text research articles on human participants. First 3 results:

Risk factors for post-ERCP cholecystitis: a single-center retrospective study.
 

Author(s): Jun Cao, Chunyan Peng, Xiwei Ding, Yonghua Shen, Han Wu, Ruhua Zheng, Lei Wang, Xiaoping Zou

Journal:

 

The risk factors for post-ERCP cholecystitis (PEC) have not been characterized. Hence, this study aimed to identify the potential risk factors for PEC.

Last Updated: 31 Dec 1969

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Differentiation of acute cholecystitis from chronic cholecystitis: Determination of useful multidetector computed tomography findings.
 

Author(s): Dong Myung Yeo, Seung Eun Jung

Journal: Medicine (Baltimore). 2018 Aug;97(33):e11851.

 

The purpose of this study was to determine the diagnostic value of multidetector computed tomography (MDCT) imaging findings, to identify the most predictive findings, and to assess diagnostic performance in the diagnosis and differentiation of acute cholecystitis from chronic cholecystitis.In ...

Last Updated: 31 Dec 1969

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Evaluation of laparoscopic cholecystectomy using indocyanine green cholangiography including cholecystitis: A retrospective study.
 

Author(s): Kiyokazu Hiwatashi, Hiroshi Okumura, Tetsuro Setoyama, Kei Ando, Yoshito Ogura, Kuniaki Aridome, Shigeho Maenohara, Shoji Natsugoe

Journal: Medicine (Baltimore). 2018 Jul;97(30):e11654.

 

Intraoperative cholangiography involving the excretion of fluorescent indocyanine green (ICG) into the bile is used to determine biliary anatomy in laparoscopic cholecystectomy (LC). This study aimed to evaluate the features of intraoperative ICG cholangiography, in LC with cholecystitis, ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cholecystitis" returned 46 free, full-text review articles on human participants. First 3 results:

Is cholecystectomy the treatment of choice for acute acalculous cholecystitis? A systematic review of the literature.
 

Author(s): Víctor Soria Aledo, Lorena Galindo Iñíguez, Diego Flores Funes, Milagros Carrasco Prats, Jose Luis Aguayo Albasini

Journal: Rev Esp Enferm Dig. 2017 Oct;109(10):708-718.

 

There is currently no consensus with regard to the use of cholecystectomy or percutaneous cholecystostomy as the therapy of choice for acute acalculous cholecystitis. The goal of this study was to review the scientific evidence on the management of these patients according to clinical ...

Last Updated: 31 Dec 1969

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Early Cholecystectomy for Acute Cholecystitis in the Elderly Population: A Systematic Review and Meta-Analysis.
 

Author(s): Charlotte S Loozen, Bert van Ramshorst, Hjalmar C van Santvoort, Djamila Boerma

Journal: Dig Surg. 2017 ;34(5):371-379.

 

In the era of advanced surgical techniques and improved perioperative care, the willingness to perform emergency operations in elderly patients continues to increase. This systematic review aimed at assessing the clinical outcomes of early cholecystectomy in elderly patients with ...

Last Updated: 31 Dec 1969

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History, Physical Examination, Laboratory Testing, and Emergency Department Ultrasonography for the Diagnosis of Acute Cholecystitis.
 

Author(s): Ashika Jain, Ninfa Mehta, Michael Secko, Joshua Schechter, Dimitri Papanagnou, Shreya Pandya, Richard Sinert

Journal: Acad Emerg Med. 2017 03;24(3):281-297.

 

Acute cholecystitis (AC) is a common differential for patients presenting to the emergency department (ED) with abdominal pain. The diagnostic accuracy of history, physical examination, and bedside laboratory tests for AC have not been quantitatively described.

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Reduction of Operating Time by a Smoke Electroprecipitation Device for Acute Cholecystitis
 

Status: Not yet recruiting

Condition Summary: Cholecystitis

 

Last Updated: 16 Aug 2018

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The Role of Ultrasound in Cholecystitis
 

Status: Recruiting

Condition Summary: Cholecystitis, Acute

 

Last Updated: 9 Aug 2018

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Bile Aspiration vs Drain in Acute Cholecystitis
 

Status: Not yet recruiting

Condition Summary: Cholecystitis, Acute

 

Last Updated: 26 Jun 2018

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