Cholestasis

Common Name(s)

Cholestasis

Cholestasis is a rare disease where a person’s liver can not move the bile it makes to the small intestine. The liver, an organ in the abdomen (belly), is responsible for producing bile, which is a compound that helps people digest fats. Once the bile has been made, it is supposed to enter the small intestine where fat is digested. However, in people with cholestasis, the bile can not move to the small intestine because of a blockage and becomes backed up in the liver. This can be caused by a number of things such as gallstones, scars from prior surgery, or certain cancers. Symptoms of cholestasis are itchiness, jaundice (yellowing of the skin), pale stool, and dark urine. Talk with your doctor to find the best treatment for you if you have been diagnosed with cholestasis.

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Advocacy and Support Organizations

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cholestasis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cholestasis" returned 516 free, full-text research articles on human participants. First 3 results:

The role of ABC transporters' gene polymorphism in the etiology of intrahepatic cholestasis of pregnancy.
 

Author(s): Krzysztof Piątek, Grażyna Kurzawińska, Justyna Magiełda, Krzysztof Drews, Magdalena Barlik, Zbyszko Malewski, Marcin Ożarowski, Małgorzata Maciejewska, Agnieszka Seremak-Mrozikiewicz

Journal: Ginekol. Pol.. 2018 ;89(7):393-397.

 

The etiology of intrahepatic cholestasis of pregnancy (ICP) involves environmental, hormonal and genetic factors. It is thought that ICP may be related to the polymorphic variants of several genes involved in the metabolism and transport of bile acids (BA). The goal of our study was ...

Last Updated: 31 Dec 1969

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Spectrum of genomic variations in Indian patients with progressive familial intrahepatic cholestasis.
 

Author(s): Anjali Sharma, Ujjal Poddar, Shikha Agnihotry, Shubha R Phadke, Surender K Yachha, Rakesh Aggarwal

Journal:

 

Progressive familial intrahepatic cholestasis (PFIC) is caused by variations in ATP8B1, ABCB11 or ABCB4 genes. Data on genetic variations in Indian patients with PFIC are lacking.

Last Updated: 31 Dec 1969

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Prostaglandin E1 Preconditioning Attenuates Liver Ischemia Reperfusion Injury in a Rat Model of Extrahepatic Cholestasis.
 

Author(s): Feng Xu, Xiaolin Liu, Chao Wang, Chaoliu Dai

Journal:

 

The aim of this study is to explore the hepatoprotective effect of intraportal prostaglandin E1 (PGE1) on liver ischemia reperfusion (IR) injury using an extrahepatic cholestatic model, observing oxidative stress markers, proinflammatory factors, apoptotic marker proteins, and an ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cholestasis" returned 69 free, full-text review articles on human participants. First 3 results:

Bile Acids in Cholestasis and its Treatment.
 

Author(s): Juan Pablo Arab, Daniel Cabrera, Marco Arrese

Journal: Ann Hepatol. 2017 11;16(Suppl. 1: s3-105.):s53-s57.

 

Bile acids (BA) are key molecules in generating bile flow, which is an essential function of the liver. In the last decades there have been great advances in the understanding of the role of a number of specific transport proteins present at the sinusoidal and canalicular membrane ...

Last Updated: 31 Dec 1969

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Progressive familial intrahepatic cholestasis: A comprehensive review of a challenging liver disease.
 

Author(s): Kavita Gaur, Puja Sakhuja

Journal: Indian J Pathol Microbiol. ;60(1):2-7.

 

Cholestatic liver disease in children represents a diagnostic and therapeutic challenge. The requirement of a multidisciplinary approach, high levels of professional expertise, and the costs of genetic testing are a few of the reasons why such patients may suffer for want of an accurate ...

Last Updated: 31 Dec 1969

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Evaluating the effectiveness and safety of ursodeoxycholic acid in treatment of intrahepatic cholestasis of pregnancy: A meta-analysis (a prisma-compliant study).
 

Author(s): Xiang Kong, Yan Kong, Fangyuan Zhang, Tingting Wang, Jin Yan

Journal: Medicine (Baltimore). 2016 Oct;95(40):e4949.

 

Intrahepatic cholestasis of pregnancy (ICP) is a specific pregnancy-related disorder without standard medical therapies. Ursodeoxycholic acid (UDCA) is the most used medicine, but the efficacy and safety of UDCA remain uncertain. Several meta-analyses had been made to assess the effects ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Use of Omega 3 Oil Emulsion for Parenteral Nutrition Associated Cholestasis
 

Status: Recruiting

Condition Summary: Cholestasis

 

Last Updated: 1 May 2017

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Compassionate Use of Omegaven to Reverse Parenteral Nutrition Induced Cholestasis
 

Status: Recruiting

Condition Summary: Cholestasis

 

Last Updated: 25 Jan 2018

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