Cholesteatoma

Common Name(s)

Cholesteatoma

Cholesteatoma is a type of skin cyst located in the middle ear. It can be congenital (present from birth), but it more commonly occurs as a complication of chronic ear infection. The hallmark symptom is a painless discharge from the ear. Hearing loss, dizziness, and facial muscle paralysis are rare but can result from continued cholesteatoma growth.  Surgery can stop infections and prevent complications.   
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cholesteatoma" for support, advocacy or research.

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Vestibular Disorders Association

VEDA's mission is to serve people with vestibular (inner ear balance) disorders by providing access to information, offering a support network, and elevating awareness of the challenges associated with these conditions.

Last Updated: 20 Feb 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cholesteatoma" for support, advocacy or research.

Logo
Vestibular Disorders Association

VEDA's mission is to serve people with vestibular (inner ear balance) disorders by providing access to information, offering a support network, and elevating awareness of the challenges associated with these conditions.

https://vestibular.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cholesteatoma" returned 148 free, full-text research articles on human participants. First 3 results:

The Role of Tympanic Membrane Retractions in Cholesteatoma Pathogenesis.
 

Author(s): Letícia Petersen Schmidt Rosito, Neil Sperling, Adriane Ribeiro Teixeira, Fábio André Selaimen, Sady Selaimen da Costa

Journal:

 

To analyze the contralateral ear (CLE) of patients with cholesteatoma and to correlate the cholesteatoma growth pattern in the affected ear with the findings in the CLE.

Last Updated: 31 Dec 1969

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Long noncoding RNAs show differential expression profiles and display ceRNA potential in cholesteatoma pathogenesis.
 

Author(s): Juanjuan Gao, Qi Tang, Xiaohui Zhu, Shihua Wang, Yongli Zhang, Wenbin Liu, Zhiqiang Gao, Hua Yang

Journal: Oncol. Rep.. 2018 May;39(5):2091-2100.

 

Cholesteatoma is a pathologically benign but clinically destructive middle ear disease, which is caused by excessive epidermal migration and uncontrolled hyperproliferation of keratinocytes of squamous epithelium, leading to various clinical manifestations and serious complications, ...

Last Updated: 31 Dec 1969

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Downregulation of MiR-203a Disinhibits Bmi1 and Promotes Growth and Proliferation of Keratinocytes in Cholesteatoma.
 

Author(s): Jian Zang, Lian Hui, Ning Yang, Bo Yang, Xuejun Jiang

Journal:

 

Keratinocytes are the predominant cell type in a cholesteatoma, and microRNA (miR)-203a has been shown to be essential for the growth and differentiation of keratinocytes. The regulatory mechanisms of miR-203a and Bmi1-the predicted target of miR-203a that is associated with cholesteatoma-have ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cholesteatoma" returned 25 free, full-text review articles on human participants. First 3 results:

Cholesteatoma Definition and Classification: A Literature Review.
 

Author(s): Justyna Rutkowska, Nuri Özgirgin, Ewa Olszewska

Journal: J Int Adv Otol. 2017 Aug;13(2):266-271.

 

Cholesteatoma is a serious otolaryngologic condition that to date remains an important problem and poses a challenge to otolaryngologists around the world. To improve the approach pertaining to the diagnosis and management of middle ear cholesteatoma, clear, clinically applicable, ...

Last Updated: 31 Dec 1969

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EAONO/JOS Joint Consensus Statements on the Definitions, Classification and Staging of Middle Ear Cholesteatoma.
 

Author(s): Matthew Yung, Tetsuya Tono, Ewa Olszewska, Yutaka Yamamoto, Holger Sudhoff, Masafumi Sakagami, Jef Mulder, Hiromi Kojima, Armağan İncesulu, Franco Trabalzini, Nuri Özgirgin

Journal: J Int Adv Otol. 2017 Apr;13(1):1-8.

 

The European Academy of Otology and Neurotology (EAONO) has previously published a consensus document on the definitions and classification of cholesteatoma. It was based on the Delphi consensus methodology involving the broad EAONO membership. At the same time, the Japanese Otological ...

Last Updated: 31 Dec 1969

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Recommendations for Potassium-Titanyl-Phosphate Laser in the Treatment of Cholesteatoma.
 

Author(s): Gavin John le Nobel, Adrian Lewis James

Journal: J Int Adv Otol. 2016 Dec;12(3):332-336.

 

Potassium-titanyl-phosphage (KTP) lasers possess many characteristics suitable for otologic surgery. The objective of this report is to provide recommendations on the use of KTP laser for cholesteatoma surgery based on a narrative review of currently available evidence. PubMed and ...

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Detection of Cholesteatoma Using Diffusion Magnetic Resonance Imaging
 

Status: Not yet recruiting

Condition Summary: Cholesteatoma

 

Last Updated: 5 Oct 2017

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Last Updated: 12 Mar 2018

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Combined Access Closed Tympanomastoidectomy: Microsurgery Allied to Endoscopy
 

Status: Recruiting

Condition Summary: Cholesteatoma; Chronic Otitis Media

 

Last Updated: 21 Sep 2017

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