Chromophobe renal cell carcinoma

Common Name(s)

Chromophobe renal cell carcinoma

Chromophobe renal cell carcinoma is a rare type of kidney cancer that develops in cells that are involved in the production of urine. Cancers form when a change (mutation) in DNA causes certain cells to grow out of control, sometimes forming a lump or a tumor. Some of these cancerous cells can break off and spread to other parts of the body where they will continue to grow (metastasis).

Chromophobe renal cell carcinoma usually occurs in adults between the ages of 40 and 60, although it can appear in all age groups. This type of carcinoma is associated with Birt-Hogg-Dubé syndrome, an inherited disorder caused by a mutation in the FLCN gene. The FLCN gene is involved in regulating cell growth, and a mutation in this gene can cause cells to grow out of control. This situation places affected individuals at higher risk of developing chromophobe renal cell carcinoma as well as noncancerous growths in the kidneys, lungs, and hair follicles.

Common symptoms include the presence of blood in the urine, pain in the back or side of the abdomen, and fatigue. Other signs include abdominal swelling or the presence of a lump in the abdominal area, which may or may not be painful. Diagnosis is usually made with a combination of a physical exam, imaging studies, blood tests, and other laboratory studies. Diagnosis may require a doctor to take a biopsy, or sample, of the tissue to look at under a microscope in order to determine if the cells are growing in an abnormal way.

Treatment may involve surgery, but treatment plans will vary based on many factors such as how large the tumor is and if it has spread to other structures. If you or a family member has been diagnosed with chromophobe renal cell carcinoma, talk to your doctor about the most current treatment options. Support groups are also available for more resources and information. Meeting with a genetic counselor may also be helpful to better understand the inherited causes of this condition.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Chromophobe renal cell carcinoma" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Chromophobe renal cell carcinoma" returned 67 free, full-text research articles on human participants. First 3 results:

[A Case Report : Spontaneous Rupture of Chromophobe Renal Cell Carcinoma].
 

Author(s): Masayuki Takata, Masanori Kohno, Kazuto Komatsu, Hiroshi Yoshida

Journal: Hinyokika Kiyo. 2016 Oct;62(10):521-523.

 

A 31-year-old man presented with sudden right flank pain. We found a right renal tumor with a perirenal hematoma on enhanced abdominal computed tomography (CT), which suggested spontaneous rupture of the renal tumor. The tumor was located at the upper pole of the right kidney, and ...

Last Updated: 31 Dec 1969

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Outcome of Patients With Metastatic Chromophobe Renal Cell Carcinoma Treated With Sunitinib.
 

Author(s): Daniel Keizman, David Sarid, Jae L Lee, Avishay Sella, Maya Gottfried, Hans Hammers, Mario A Eisenberger, Michael A Carducci, Victoria Sinibaldi, Victoria Neiman, Eli Rosenbaum, Avivit Peer, Avivit Neumann, Wilmosh Mermershtain, Keren Rouvinov, Raanan Berger, Ibrahim Yildiz

Journal: Oncologist. 2016 10;21(10):1212-1217.

 

Sunitinib is a standard treatment for metastatic clear cell renal cell carcinoma (mccRCC). Data on its activity in the rare variant of metastatic chromophobe renal cell carcinoma (mchRCC), are limited. We aimed to analyze the activity of sunitinib in a relatively large and homogenous ...

Last Updated: 31 Dec 1969

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Dysfunctional miRNA-Mediated Regulation in Chromophobe Renal Cell Carcinoma.
 

Author(s): Xiaohan Sun, Junying Zhang

Journal:

 

Past research on pathogenesis of a complex disease suggests that differentially expressed message RNAs (mRNAs) can be noted as biomarkers of a disease. However, significant miRNA-mediated regulation change might also be more deep underlying cause of a disease. In this study, a miRNA-mediated ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Chromophobe renal cell carcinoma" returned 7 free, full-text review articles on human participants. First 3 results:

[Chromophobe renal cell carcinoma: about four cases and review of the literature].
 

Author(s): Yddoussalah Othmane, Lahyani Mounir, Karmouni Tarik, Elkhader Khalid, Koutani Abdellatif, Ibn Attya Andaloussi Ahmed

Journal:

 

Last Updated: 31 Dec 1969

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Chromophobe renal cell carcinoma: a review of an uncommon entity.
 

Author(s): Francisco Emilio Vera-Badillo, Esther Conde, Ignacio Duran

Journal: Int. J. Urol.. 2012 Oct;19(10):894-900.

 

Renal cell carcinoma is the most common neoplasm of the kidney. It is a heterogeneous disease, comprised of different histological variants with a distinct clinical course, genetics and response to treatment. The various subtypes identified include clear cell, papillary and chromophobe, ...

Last Updated: 31 Dec 1969

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Paraganglioma of seminal vesicle and chromophobe renal cell carcinoma: a case report and literature review.
 

Author(s): César Augusto Alvarenga, José Manuel Lopes, João Vinagre, Paula Itagyba Paravidino, Marcelo Alvarenga, Adilson Prando, Lísias Nogueira Castilho, Paula Soares, Athanase Billis

Journal: Sao Paulo Med J. 2012 ;130(1):57-60.

 

Extra-adrenal paragangliomas are rare tumors that have been reported in many locations, including the kidney, urethra, urinary bladder, prostate, spermatic cord, gallbladder, uterus and vagina.

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Phase II Sequential Treatment Trial of Single Agent Nivolumab, Then Combination Ipilimumab + Nivolumab in Metastatic or Unresectable Non-Clear Cell Renal Cell Carcinoma (ANZUP1602)
 

Status: Recruiting

Condition Summary: Renal Cell Carcinoma; Papillary Renal Cell Carcinoma Type 1; Papillary Renal Cell Carcinoma Type 2; Chromophobe Renal Cell Carcinoma; Sarcomatoid Renal Cell Carcinoma; Xp11 Translocation Carcinoma

 

Last Updated: 2 Apr 2018

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A Study Evaluating the Safety, Pharmacokinetics and Anti-Tumor Activity of ABBV-176 in Subjects With Advanced Solid Tumors Likely to Express Prolactin Receptor (PRLR)
 

Status: Recruiting

Condition Summary: Advanced Solid Tumors Likely to Express Prolactin Receptor (PRLR)

 

Last Updated: 25 Apr 2018

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