Chromosome Translocations

Common Name(s)

Chromosome Translocations

Description for this condition is not yet available.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Chromosome Translocations" for support, advocacy or research.

Trisomy 18 Foundation

The Trisomy 18 Foundation (T18F) is the leading national organization devoted exclusively to improving outcomes for Trisomy 18 families in the United States. Committed to the support of medical research in finding effective treatments and preventions for Trisomy 18. The T18F also educates patient families and physicians about prevention, diagnosis and the treatment of Trisomy 18. The T18F is an active advocate for the Trisomy 18 community, helping to raise awareness of this disease and the need for treatments. The T18F's website is the premier source for educating the public about Trisomy 18 and impacted families..

Last Updated: 24 Jul 2015

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Chromosome Disorder Outreach, Inc.

Our mission is to provide support to parents of children born with rare chromosome disorders, to gather & disseminate information, & to promote research & a positive community understanding of these disorders.

Last Updated: 2 Nov 2012

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Chromosome Translocations" for support, advocacy or research.

Trisomy 18 Foundation

The Trisomy 18 Foundation (T18F) is the leading national organization devoted exclusively to improving outcomes for Trisomy 18 families in the United States. Committed to the support of medical research in finding effective treatments and preventions for Trisomy 18. The T18F also educates patient families and physicians about prevention, diagnosis and the treatment of Trisomy 18. The T18F is an active advocate for the Trisomy 18 community, helping to raise awareness of this disease and the need for treatments. The T18F's website is the premier source for educating the public about Trisomy 18 and impacted families..

http://www.trisomy18.org

Last Updated: 24 Jul 2015

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Chromosome Disorder Outreach, Inc.

Our mission is to provide support to parents of children born with rare chromosome disorders, to gather & disseminate information, & to promote research & a positive community understanding of these disorders.

http://www.chromodisorder.org

Last Updated: 2 Nov 2012

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Chromosome Translocations" returned 77 free, full-text research articles on human participants. First 3 results:

Coexistence of t(2;14;11)(p16.1;q32;q23) and t(14;19)(q32;q13.3) chromosome translocations in a patient with chronic lymphocytic leukemia: A case report.
 

Author(s): Guangming Liu, Zhongmei Wen, Xianglan Lu, Young Mi Kim, Xianfu Wang, Rebecca M Crew, Mohamad A Cherry, Shibo Li, Yuanyuan Liu

Journal: Medicine (Baltimore). 2017 Dec;96(51):e9169.

 

With combination of multiple techniques, we have successfully characterized unique, complex chromosomal changes in a patient with chronic lymphocytic leukemia (CLL), a lymphoproliferative disorder.

Last Updated: 31 Dec 1969

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Whole-Genome Sequencing of Cytogenetically Balanced Chromosome Translocations Identifies Potentially Pathological Gene Disruptions and Highlights the Importance of Microhomology in the Mechanism of Formation.
 

Author(s): Daniel Nilsson, Maria Pettersson, Peter Gustavsson, Alisa Förster, Wolfgang Hofmeister, Josephine Wincent, Vasilios Zachariadis, Britt-Marie Anderlid, Ann Nordgren, Outi Mäkitie, Valtteri Wirta, Max Käller, Francesco Vezzi, James R Lupski, Magnus Nordenskjöld, Elisabeth Syk Lundberg, Claudia M B Carvalho, Anna Lindstrand

Journal: Hum. Mutat.. 2017 Feb;38(2):180-192.

 

Most balanced translocations are thought to result mechanistically from nonhomologous end joining or, in rare cases of recurrent events, by nonallelic homologous recombination. Here, we use low-coverage mate pair whole-genome sequencing to fine map rearrangement breakpoint junctions ...

Last Updated: 31 Dec 1969

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The Impact of Variant Philadelphia Chromosome Translocations on the Clinical Course of Chronic Myeloid Leukemia.
 

Author(s): Damla Eyüpoğlu, Süreyya Bozkurt, İbrahim Haznedaroğlu, Yahya Büyükaşık, Deniz Güven

Journal: Turk J Haematol. 2016 Mar;33(1):60-5.

 

Chronic myeloid leukemia (CML) is genetically characterized by the presence of the reciprocal translocation t(9;22) with the formation of Philadelphia (Ph) chromosome. Sometimes, the Ph translocation is generated by variant rearrangements. The prognostic impact of the variant translocations ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Chromosome Translocations" returned 9 free, full-text review articles on human participants. First 3 results:

Clinical feature of infertile men carrying balanced translocations involving chromosome 10: Case series and a review of the literature.
 

Author(s): Hongguo Zhang, Ruixue Wang, Leilei Li, Yuting Jiang, Han Zhang, Ruizhi Liu

Journal: Medicine (Baltimore). 2018 Apr;97(15):e0452.

 

Infertile male carrying balanced translocations can be broadly divided into two types: pregestational and gestational infertility. Chromosome and breakpoints involved translocation should be considered in genetic counselling for these patients. To date, > 100 cases have been described ...

Last Updated: 31 Dec 1969

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Selective chromatid segregation mechanism proposed for the human split hand/foot malformation development by chromosome 2 translocations: A perspective.
 

Author(s): Amar J S Klar

Journal: Dev. Biol.. 2015 Dec;408(1):7-13.

 

Three unrelated chromosome 2q14.1-14.2 region translocations caused the split hand/foot limb malformation development in humans by an unknown mechanism. Their etiology was described by the autosomal dominant inheritance with incomplete penetrance genetic model although authors stated, ...

Last Updated: 31 Dec 1969

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A role for epigenetics in the formation of chromosome translocations in acute leukemia.
 

Author(s): Heidi J Gill Super

Journal: Cancer Genet. 2015 May;208(5):230-6.

 

In general, the field of cancer genetics seems to have shifted its focus from cancer-associated genes to cancer-associated epigenetic activity. An abundance of evidence suggests that epigenetic malfunction, such as aberrant histone modification, and altered DNA methylation, is at ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

PETHEMA-BLIN-01/PET069014 (BLIN-01)
 

Status: Not yet recruiting

Condition Summary: Philadelphia Chromosome-negative or BCR-ABL-negative, CD19-positive ALL

 

Last Updated: 1 May 2018

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A Phase III Randomized Trial of the Reduction of Chemotherapy in Philadelphia Chromosome-positive ALL of Young Adults
 

Status: Recruiting

Condition Summary: Philadelphia Chromosome Positive Adult Acute Lymphoblastic Leukemia

 

Last Updated: 7 Dec 2017

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Study of Inotuzumab Ozogamicin Combined to Chemotherapy in Older Patients With Philadelphia Chromosome-negative CD22+ B-cell Precursor ALL
 

Status: Recruiting

Condition Summary: Acute Lymphoblastic Leukemia (ALL) - Philadelphia Chromosome (Ph)-Negative CD22+ B-cell Precursor (BCP)

 

Last Updated: 4 Apr 2018

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