Craniopharyngioma

Common Name(s)

Craniopharyngioma

A craniopharyngioma is a slow-growing benign tumor that develops near the pituitary gland (a small endocrine gland at the base of the brain) and the hypothalamus (a small cone-shaped organ connected to the pituitary gland by nerves).  This tumor most commonly affects children between 5 and 10 years of age; however, adults can sometimes be affected.  Craniopharyngiomas are thought to arise from remnants of the craniopharyngeal duct and/or Rathke cleft or from metaplasia (abnormal transformation of cells) of squamous epithelial cell remnants of the stomadeum. Craniopharyngioma is treated with surgery alone or by surgery followed by radiation.

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Craniopharyngioma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Craniopharyngioma" returned 183 free, full-text research articles on human participants. First 3 results:

Phosphorus-32 interstitial radiotherapy for recurrent craniopharyngioma: Expressions of vascular endothelial growth factor and its receptor-2 and imaging features of tumors are associated with tumor radiosensitivity.
 

Author(s): Chenhao Hu, Jinhui Chen, Yuhong Meng, Jianning Zhang, Yaming Wang, Rui Liu, Xin Yu

Journal: Medicine (Baltimore). 2018 Jun;97(26):e11136.

 

To investigate the relationship of the expression of vascular endothelial growth factor (VEGF)/vascular endothelial growth factor receptor-2 (VEGFR-2) and imaging features with the therapeutic efficacy of Phosphorus-32 colloid interstitial radiotherapy in recurrent craniopharyngioma.Thirty-two ...

Last Updated: 31 Dec 1969

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Microstructural white matter alterations and hippocampal volumes are associated with cognitive deficits in craniopharyngioma.
 

Author(s): S Fjalldal, C Follin, D Svärd, L Rylander, S Gabery, Å Petersén, D van Westen, P C Sundgren, I M Björkman-Burtscher, J Lätt, B Ekman, A Johanson, E M Erfurth

Journal: Eur. J. Endocrinol.. 2018 Jun;178(6):577-587.

 

Patients with craniopharyngioma (CP) and hypothalamic lesions (HL) have cognitive deficits. Which neural pathways are affected is unknown.

Last Updated: 31 Dec 1969

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Craniopharyngioma - a chronic disease.
 

Author(s): Hermann Müller

Journal:

 

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Craniopharyngioma" returned 22 free, full-text review articles on human participants. First 3 results:

Paraneoplastic limbic encephalitis associated with mixed olfactory neuroblastoma and craniopharyngioma: A case report and literature review.
 

Author(s): Hiroshi Nagafuji, Hidenori Yokoi, Masachika Fujiwara, Dai Sato, Koichiro Saito

Journal: Medicine (Baltimore). 2018 Jun;97(24):e10932.

 

Paraneoplastic limbic encephalitis (PLE) is a rare disorder of the nervous system associated with malignant disease. It has a subacute onset with the following symptoms: cognitive dysfunction, seizures, irritability, hallucinations, and short-term memory loss. Herein, we report the ...

Last Updated: 31 Dec 1969

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Genetically engineered mouse models of craniopharyngioma: an opportunity for therapy development and understanding of tumor biology.
 

Author(s): John Richard Apps, Juan Pedro Martinez-Barbera

Journal: Brain Pathol.. 2017 May;27(3):364-369.

 

Adamantinomatous craniopharyngioma (ACP) is the commonest tumor of the sellar region in childhood. Two genetically engineered mouse models have been developed and are giving valuable insights into ACP biology. These models have identified novel pathways activated in tumors, revealed ...

Last Updated: 31 Dec 1969

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Concise Review: Paracrine Role of Stem Cells in Pituitary Tumors: A Focus on Adamantinomatous Craniopharyngioma.
 

Author(s): Juan Pedro Martinez-Barbera, Cynthia L Andoniadou

Journal: Stem Cells. 2016 Feb;34(2):268-76.

 

The existence of tissue-specific progenitor/stem cells in the adult pituitary gland of the mouse has been demonstrated recently using genetic tracing experiments. These cells have the capacity to differentiate into all of the different cell lineages of the anterior pituitary and self-propagate ...

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Examination of Sleep and Family Functioning in Pediatric Craniopharyngioma Patients
 

Status: Recruiting

Condition Summary: Craniopharyngioma

 

Last Updated: 13 Feb 2018

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Vemurafenib and Cobimetinib in Treating Patients With BRAF V600E Mutation Positive Craniopharyngioma
 

Status: Recruiting

Condition Summary: BRAF V600E Mutation Present; Papillary Craniopharyngioma

 

Last Updated: 16 Jul 2018

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