Craniorachischisis

Common Name(s)

Craniorachischisis

Craniorachischisis is the most severe type of neural tube defect in which both the brain and spinal cord remain open; both anencephaly and spina bifida (from the cervical region to the lumbar or sacral region of the spine) are present. Fetuses with craniorachischisis often miscarry during pregnancy or die shortly after birth. The cause is thought to be multifactorial, which means that a combination of genetic and non-genetic factors play a role.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Craniorachischisis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Craniorachischisis" returned 4 free, full-text research articles on human participants. First 3 results:

Mutations in the planar cell polarity genes CELSR1 and SCRIB are associated with the severe neural tube defect craniorachischisis.
 

Author(s): Alexis Robinson, Sarah Escuin, Kit Doudney, Michel Vekemans, Roger E Stevenson, Nicholas D E Greene, Andrew J Copp, Philip Stanier

Journal: Hum. Mutat.. 2012 Feb;33(2):440-7.

 

Craniorachischisis (CRN) is a severe neural tube defect (NTD) resulting from failure to initiate closure, leaving the hindbrain and spinal neural tube entirely open. Clues to the genetic basis of this condition come from several mouse models, which harbor mutations in core members ...

Last Updated: 13 Jan 2012

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Prenatal diagnosis of pentalogy of cantrell with craniorachischisis by three-dimensional ultrasonography in the first trimester.
 

Author(s): Susumu Murata, Masahiko Nakata, Masahiro Sumie, Masakazu Mastsuabra, Norihiro Sugino

Journal: Taiwan J Obstet Gynecol. 2009 Sep;48(3):317-8.

 

Last Updated: 2 Oct 2009

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Transvaginal sonographic diagnosis of iniencephaly apertus and craniorachischisis at 9 weeks' gestation.
 

Author(s): F Cuillier, P Koenig, L Lagarde, J F Cartault

Journal: Ultrasound Obstet Gynecol. 2003 Dec;22(6):657-8.

 

Last Updated: 22 Dec 2003

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Craniorachischisis" returned 1 free, full-text review articles on human participants. First 3 results:

Concomitant craniorachischisis and omphalocele in a male fetus: prenatal magnetic resonance imaging findings and literature review.
 

Author(s): Chih-Ping Chen, Yu-Peng Liu, Fuu-Jen Tsai, Chen-Yu Chen, Hung-Hung Lin, Pei-Chen Wu, Wayseen Wang

Journal: Taiwan J Obstet Gynecol. 2009 Sep;48(3):286-91.

 

To present the prenatal magnetic resonance imaging (MRI) findings of concomitant craniorachischisis and omphalocele, review the literature, and discuss the pathogenesis.

Last Updated: 2 Oct 2009

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.