Cretinism

Common Name(s)

Cretinism

Cretinism is a condition characterized by stunted physical and mental growth due to a congenital deficiency in thyroid hormones usually due to maternal hypothyroidism. Congenital means the condition is present at birth and maternal hypothyroidism means the mother's thryoid gland is not functioning properly. During the first few months of pregnancy, the developing baby depends solely on the mother for its thyroid hormone supply, which is essential for normal growth and brain development. As the pregnancy continues, the baby's thyroid begins to function but the mother continues to supply the thyroid hormone T4. The effects caused by low thyroid hormone levels during pregnancy can be permanent if not corrected soon after birth. Congenital hypothyroidism can also be caused by a defect in the developing baby's thyroid gland. Physical symptoms if untreated may include less than average height, swelling of the skin, loss of water and hair, delayed bone maturation and puberty, thickened skin, enlarged tongue, and protruding abdomen. Delayed ovulation and infertility are also common. There may be mild to severe cognitive impairments as well that include impaired thought and language processes and slower reflexes. If detected early, usually through newborn screening, and treated with thyroxine, then cretinism due to congenital hypothyroidism is almost completely prevented. The term "cretinism" is rarely used anymore due to negative associations with the word. Please also see Congenital hypothyroidism.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cretinism" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cretinism" returned 30 free, full-text research articles on human participants. First 3 results:

Cretinism presenting as a pseudotumour.
 

Author(s): D M Mahesh, Felix K Jebasingh, Manash P Baruah, Nihal Thomas

Journal:

 

A 43-year-old man from a remote part of India (over 1800 km from our institution), presented with a headache of 3 years duration. He was of short stature, had delayed puberty and was mentally retarded. On evaluation he was detected to have primary hypothyroidism with markedly elevated ...

Last Updated: 10 Jan 2015

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The longitudinal course of two cases with cretinism diagnosed after adolescence.
 

Author(s): Tsunenori Hirayama, Kohji Niho, Osamu Fujino, Mutsumi Murakami

Journal: J Nippon Med Sch. 2003 Apr;70(2):175-8.

 

In Japan, mass screening tests on newborns for Cretinism have been performed since 1984, Cretinism is a very rare condition. We report the clinical course and complications of longitudinal thyroid hormone replacement therapy (liothyronine sodium: T3) of two women with Cretinism and ...

Last Updated: 12 Jun 2003

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Goitre, cretinism and iodine in South Asia: historical perspectives on a continuing scourge.
 

Author(s): M Miles

Journal: Med Hist. 1998 Jan;42(1):47-67.

 

Last Updated: 28 Apr 1998

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cretinism" returned 1 free, full-text review articles on human participants. First 3 results:

Iodine and the "near" eradication of cretinism.
 

Author(s): Sana Syed

Journal: Pediatrics. 2015 Apr;135(4):594-6.

 

Last Updated: 2 Apr 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

A Study of 99m Tc Pertechnetate Produced in High Energy Cyclotron in Patients With Thyroid Scan Indication
 

Status: Recruiting

Condition Summary: Autoimmune Thyroid Disease; Congenital Hypothyroidism

 

Last Updated: 5 Apr 2016

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