Crigler-Najjar syndrome

Common Name(s)

Crigler-Najjar syndrome

Description for this condition is not yet available.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Crigler-Najjar syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Crigler-Najjar syndrome" returned 43 free, full-text research articles on human participants. First 3 results:

Differences in UGT1A1 gene mutations and pathological liver changes between Chinese patients with Gilbert syndrome and Crigler-Najjar syndrome type II.
 

Author(s): Lei Sun, Man Li, Liang Zhang, Xiaoying Teng, Xiangmei Chen, Xingang Zhou, Zhiyuan Ma, Liming Qi, Peng Wang

Journal: Medicine (Baltimore). 2017 Nov;96(45):e8620.

 

Diagnosis of Crigler-Najjar syndrome type II (CNS-II) and Gilbert syndrome (GS) based on the serum bilirubin concentration is difficult, because this parameter can fluctuate under certain conditions. The aim of this study was to explore differences in UGT1A1 gene mutations, which ...

Last Updated: 31 Dec 1969

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Promoterless gene targeting without nucleases rescues lethality of a Crigler-Najjar syndrome mouse model.
 

Author(s): Fabiola Porro, Giulia Bortolussi, Adi Barzel, Alessia De Caneva, Alessandra Iaconcig, Simone Vodret, Lorena Zentilin, Mark A Kay, Andrés F Muro

Journal: EMBO Mol Med. 2017 10;9(10):1346-1355.

 

Crigler-Najjar syndrome type I (CNSI) is a rare monogenic disease characterized by severe neonatal unconjugated hyperbilirubinemia with a lifelong risk of neurological damage and death. Liver transplantation is the only curative option, which has several limitations and risks. We ...

Last Updated: 31 Dec 1969

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[Phenobarbital in Crigler-Najjar syndrome type 1: A therapeutic option].
 

Author(s): Irene Rubio Gómez, María Fernanda López González, María Mercedes Ibáñez Alcalde, Francisco Cañabate Reche

Journal: An Pediatr (Barc). 2016 Aug;85(2):115-6.

 

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Crigler-Najjar syndrome" returned 2 free, full-text review articles on human participants. First 3 results:

Pregnancy outcome in maternal Crigler-Najjar syndrome type II: a case report and systematic review of the literature.
 

Author(s): V Passuello, A G Puhl, S Wirth, E Steiner, C Skala, H Koelbl, N Kohlschmidt

Journal: Fetal. Diagn. Ther.. 2009 ;26(3):121-6.

 

To report a case of maternal Crigler-Najjar syndrome (CNS) type II in pregnancy, systematically review the literature for similar case reports, and to evaluate whether pregnancy is safe in patients with the disease. Data sources included the PubMed and up to date databases.

Last Updated: 31 Dec 1969

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Liver cell transplantation for Crigler-Najjar syndrome type I: update and perspectives.
 

Author(s): Philippe-A Lysy, Mustapha Najimi, Xavier Stephenne, Annick Bourgois, Francoise Smets, Etienne-M Sokal

Journal: World J. Gastroenterol.. 2008 Jun;14(22):3464-70.

 

Liver cell transplantation is an attractive technique to treat liver-based inborn errors of metabolism. The feasibility and efficacy of the procedure has been demonstrated, leading to medium term partial metabolic control of various diseases. Crigler-Najjar is the paradigm of such ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Gene Therapy for Severe Crigler Najjar Syndrome
 

Status: Recruiting

Condition Summary: Crigler-Najjar Syndrome

 

Last Updated: 15 May 2018

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Clinical Assessment Study in Crigler-Najjar Syndrome
 

Status: Recruiting

Condition Summary: Crigler-Najjar Syndrome

 

Last Updated: 13 Aug 2018

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Gene Transfer Clinical Study in Crigler-Najjar Syndrome
 

Status: Recruiting

Condition Summary: Crigler-Najjar Syndrome

 

Last Updated: 13 Aug 2018

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