Cryofibrinogenemia

Common Name(s)

Cryofibrinogenemia

Cryofibrinogenemia is a rare blood disorder in which there is a certain abnormal protein called cryofibrinogen present in the blood. In most cases, individuals experience no symptoms. However in more moderate to serious cases, symptoms can include skin lesions, red or purple marks (purpura), poor blood circulation, stroke, heart attack, blood clots, and extra sensitivity to cold. It is currently unclear what causes cryofibrinogenemia, but it is sometimes associated with certain cancers and infections such as strep, tuberculosis, hepatitis C and others. A simple blood test is usually conducted to diagnose this condition, and sometimes skin biopsies may be needed. Additional testing may be needed to determine if there is an underlying cause such as cancer or infection. Cryofibrinogenemia is treatable and potentially reversible through corticosteroid drugs. People affected with this condition should also avoid extremely cold temperatures. If you or a family member has been diagnosed with cryofibrinogenemia, talk with your doctor about the most current treatment options.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cryofibrinogenemia" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cryofibrinogenemia" returned 5 free, full-text research articles on human participants. First 3 results:

Images in clinical medicine. Familial primary cryofibrinogenemia.
 

Author(s): Philippe Begin, Georgette Leclerc

Journal: N. Engl. J. Med.. 2013 Aug;369(8):e10.

 

Last Updated: 22 Aug 2013

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Cryofibrinogenemia associated with Sjögren's syndrome: a case of successful treatment with high-dose corticosteroid.
 

Author(s): Ken Yoshida, Toru Yokoyama, Yasuhiko Toyokawa, Jun Yasuda, Isamu Kingetsu, Daitaro Kurosaka, Akio Yamada

Journal: Intern. Med.. 2007 ;46(13):1039-42.

 

Cryofibrinogenemia (CF) has not been often reported as a complication of various rheumatic diseases. We describe a 44-year-old woman with CF associated with Sjögren's syndrome (SS), who developed digital necrotic ulcerations and purpura of the lower legs. Cryoprecipitate was detected ...

Last Updated: 2 Jul 2007

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Cryofibrinogenemia and skin necrosis in a patient with diffuse large cell lymphoma after high-dose chemotherapy and autologous stem cell transplantation.
 

Author(s): A Shimoni, M Körbling, R Champlin, J Molldrem

Journal: Bone Marrow Transplant.. 2000 Dec;26(12):1343-5.

 

A 34-year-old woman with diffuse mediastinal B cell large cell lymphoma presented 60 days after high-dose chemotherapy and autologous stem cell transplantation, and post-transplant immunotherapy with interleukin-2, with skin necrosis in the ears and extremities. Extensive work-up ...

Last Updated: 6 Mar 2001

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cryofibrinogenemia" returned 1 free, full-text review articles on human participants. First 3 results:

Cryofibrinogenemia After a Liver Transplant: First Reported Case Posttransplant and a Case-Based Review of the Nontransplant Literature.
 

Author(s): Yuanyuan Chen, Gayatri M Sreenivasan, Kam Shojania, Eric M Yoshida

Journal: Exp Clin Transplant. 2015 Jun;13(3):290-4.

 

Cryofibrinogenemia is a rare disorder in which plasma, not serum, forms a cryoprecipitate. Patients with cryofibrinogenemia may be asymptomatic, or they may have painful ulcers, purpura, livedo reticularis, Raynaud phenomenon, perniosis of the extremities, thrombosis, and arthralgia. ...

Last Updated: 19 Jun 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

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