Cryoglobulinemia

Common Name(s)

Cryoglobulinemia

Cryoglobulinemia is a condition that can affect blood vessels throughout the body. This condition is caused by the presence of abnormal proteins in the blood called cryoglobulins. These abnormal proteins become solid in cold temperatures and block blood flow. Symptoms may include difficulty breathing, tiredness, glomerulonephritis, joint and muscle pain, purpura, Raynaud's phenomenon, skin ulcers, and skin death.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cryoglobulinemia" for support, advocacy or research.

Alliance for Cryoglobulinemia

Alliance for Cryoglobulinemia is an inclusive network of patients, caregivers, family, medical professionals and other supporters dedicated to improving quality of life for people with cryoglobulinemia. Our goal is to create a platform that links all efforts of campaigns, research, support and other resources related to cryoglobulinemia. We utilize medical advisors, community networking, crowd-funding, peer to peer support, social media and campaign strategies to advocate awareness, patient support, education and research.

Last Updated: 24 Apr 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cryoglobulinemia" for support, advocacy or research.

Alliance for Cryoglobulinemia

Alliance for Cryoglobulinemia is an inclusive network of patients, caregivers, family, medical professionals and other supporters dedicated to improving quality of life for people with cryoglobulinemia. Our goal is to create a platform that links all efforts of campaigns, research, support and other resources related to cryoglobulinemia. We utilize medical advisors, community networking, crowd-funding, peer to peer support, social media and campaign strategies to advocate awareness, patient support, education and research.

http://allianceforcryo.org/

Last Updated: 24 Apr 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cryoglobulinemia" returned 206 free, full-text research articles on human participants. First 3 results:

Interstitial granulomatous dermatitis in a patient with chronic hepatitis C and mixed cryoglobulinemia.
 

Author(s): M Rato, F Gil, A F Monteiro, J Aranha, E Tavares

Journal:

 

A 55-year-old man presented with a history of asymptomatic, bilateral, figurate dermatosis consisting of erythematous, annular, linear, andarciform, indurated nodules and plaques on the lateral walls of thorax, flanks, and hypogastrium. His medical history was positive for chronic ...

Last Updated: 31 Dec 1969

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Lymphoproliferative disease with mixed cryoglobulinemia and hyperviscosity syndrome in an HIV-infected patient: HCV is the only culprit.
 

Author(s): Paola Zanotti, Ilaria Izzo, Salvatore Casari, Chiara Cattaneo, Serena Zaltron, Angiola Spinetti, Silvia Odolini, Claudia Chirico, Cecilia Grecchi, Elena Festa, Francesco Castelli

Journal: New Microbiol.. 2017 Oct;40(4):289-290.

 

The availability of direct antiviral agents (DAAs) offers the possibility to treat HCV-infected patients with a high rate of efficacy and a good safety profile. Little is known about the benefit of DAAs on HCV-related hematological diseases and their complications. We describe the ...

Last Updated: 31 Dec 1969

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Reversion of anergy signatures in clonal CD21 B cells of mixed cryoglobulinemia after clearance of HCV viremia.
 

Author(s): Martina Del Padre, Laura Todi, Milica Mitrevski, Ramona Marrapodi, Stefania Colantuono, Massimo Fiorilli, Milvia Casato, Marcella Visentini

Journal: Blood. 2017 07;130(1):35-38.

 

Hepatitis C virus (HCV) causes mixed cryoglobulinemia (MC) by driving clonal expansion of IgMCD27 B cells. These cells display both the features of anergy induced by continual engagement of the B-cell receptor (BCR), such as high expression of phosphorylated extracellular signal-regulated ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cryoglobulinemia" returned 21 free, full-text review articles on human participants. First 3 results:

How I treat cryoglobulinemia.
 

Author(s): Eli Muchtar, Hila Magen, Morie A Gertz

Journal: Blood. 2017 01;129(3):289-298.

 

Cryoglobulinemia is a distinct entity characterized by the presence of cryoglobulins in the serum. Cryoglobulins differ in their composition, which has an impact on the clinical presentation and the underlying disease that triggers cryoglobulin formation. Cryoglobulinemia is categorized ...

Last Updated: 31 Dec 1969

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[Renal damage caused by Rhupus syndrome associated with anti-neutrophil cytoplasmic antibodies vasculitis and cryoglobulinemia].
 

Author(s): Xin-ju Zhao, Tao Wei, Bao Dong, Yuan Jia, Mei Wang

Journal: Beijing Da Xue Xue Bao. 2015 Oct;47(5):870-4.

 

We analyzed the clinicopathological characteristics of one patient with Rhupus syndrome associated nephropathy in Peking University People's Hospital, and reviewed the related literature. The patient was a middle aged female. She developed rheumatoid arthritis first, and then manifested ...

Last Updated: 31 Dec 1969

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Thyroid involvement in hepatitis C - associated mixed cryoglobulinemia.
 

Author(s): Poupak Fallahi, Silvia Martina Ferrari, Dilia Giuggioli, Andreina Manfredi, Caterina Mancusi, Silvia Fabiani, Marco Centanni, Santino Marchi, Clodoveo Ferri, Alessandro Antonelli

Journal: Hormones (Athens). ;13(1):16-23.

 

The prevalence and clinical features of thyroid involvement in patients with hepatitis C virus-associated mixed cryoglobulinemia (MC+HCV) have been reviewed.

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Efficacy of All-Oral Anti-Viral Therapy for Symptomatic Hepatitis C Virus Infection-Related Cryoglobulinemia
 

Status: Recruiting

Condition Summary: Hepatitis C; Cryoglobulinemia

 

Last Updated: 8 Apr 2018

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Pathology of Hepatitis c Nephropathy
 

Status: Not yet recruiting

Condition Summary: Cryoglobulinaemia Due to Chronic Hepatitis C

 

Last Updated: 18 Mar 2018

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Long-term Outcomes of Chronic Hepatitis C Patients Post Sofosbuvir-based Treatment
 

Status: Recruiting

Condition Summary: Liver Fibroses; HepatoCellular Carcinoma; Cryoglobulinemia; Metabolic Disease; Diabetes Mellitus

 

Last Updated: 14 May 2018

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