Cryoglobulinemic vasculitis

Common Name(s)

Cryoglobulinemic vasculitis

Cryoglobulinemic vasculitis is damage or inflammation of blood vessels and surrounding tissues (vasculitis) that is caused by the buildup of abnormal proteins in the blood (cryoglobulins). Cryoglobulins have properties that cause them to thicken and clump together at cold temperatures. At normal temperatures, cryoglobulins do not clump together. However, when blood reaches temperatures below 98.6 degrees Fahrenheit (normal body temperature), these proteins clump together and cause the blood to become thick. This leads to the deposit of protein clumps in blood vessels. Symptoms of cryoglobulinemic vasculitis can vary. Some individuals with cryoglobulinemic vasculitis may experience no symptoms at all while others may have many symptoms. Symptoms may include a rash on the lower limbs, joint inflammation (arthritis), abdominal pain, and kidney failure.

Cryoglobulinemic vasculitis typically occurs in people who are 50 years or older. The exact cause of cryoglobulinemic vasculitis is not known. However, it is known to be associated with an underlying diagnosis, such as hepatitis C, autoimmune disease and different forms of cancer. Diagnosis of cryoglobulinemic vasculitis may involve a biopsy of the affected tissue or organ, assessment of clinical symptoms, and laboratory tests to assess proteins in the blood. Addressing the associated condition is the most common and effective form of treatment. For severe forms, treatment with medications may be necessary. Talk with a physician about the right treatment for you.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cryoglobulinemic vasculitis" for support, advocacy or research.

Alliance for Cryoglobulinemia

Alliance for Cryoglobulinemia is an inclusive network of patients, caregivers, family, medical professionals and other supporters dedicated to improving quality of life for people with cryoglobulinemia. Our goal is to create a platform that links all efforts of campaigns, research, support and other resources related to cryoglobulinemia. We utilize medical advisors, community networking, crowd-funding, peer to peer support, social media and campaign strategies to advocate awareness, patient support, education and research.

Last Updated: 24 Apr 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cryoglobulinemic vasculitis" for support, advocacy or research.

Alliance for Cryoglobulinemia

Alliance for Cryoglobulinemia is an inclusive network of patients, caregivers, family, medical professionals and other supporters dedicated to improving quality of life for people with cryoglobulinemia. Our goal is to create a platform that links all efforts of campaigns, research, support and other resources related to cryoglobulinemia. We utilize medical advisors, community networking, crowd-funding, peer to peer support, social media and campaign strategies to advocate awareness, patient support, education and research.

http://allianceforcryo.org/

Last Updated: 24 Apr 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cryoglobulinemic vasculitis" returned 12 free, full-text research articles on human participants. First 3 results:

IgG4-Related Sialoadenitis with a Skin Lesion and Multiple Mononeuropathies Suggesting Coexistent Cryoglobulinemic Vasculitis.
 

Author(s): Mari Kamiya, Peter Y Shane, Makoto Soejima, Shuji Tohda, Nobuyuki Miyasaka, Hitoshi Kohsaka

Journal: Intern. Med.. 2016 ;55(10):1355-61.

 

A 68-year-old man was admitted because of weakness of the left leg, dysesthesiae of the extremities and bilateral lower extremity purpura. A neurological examination showed mononeuritis multiplex with laboratory evidence of hypocomplementemia, cryoglobulinemia and leukocytoclastic ...

Last Updated: 16 May 2016

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Retreatment regimen of rituximab monotherapy given at the relapse of severe HCV-related cryoglobulinemic vasculitis: Long-term follow up data of a randomized controlled multicentre study.
 

Author(s): Luca Quartuccio, Francesca Zuliani, Laura Corazza, Patrizia Scaini, Roberta Zani, Marco Lenzi, Antonio Tavoni, Marco Sebastiani, Simone Baldovino, Teresa Urraro, Francesco Saccardo, Costanza Sbreglia, Cesare Mazzaro, Piero Pioltelli, Paolo Fraticelli, Davide Filippini, Armando Gabrielli, Oreste Perrella, Salvatore Scarpato, Dario Roccatello, Anna Linda Zignego, Clodoveo Ferri, Stefano Bombardieri, Maurizio Pietrogrande, Giuseppe Monti, Massimo Galli, Salvatore De Vita

Journal: J. Autoimmun.. 2015 Sep;63():88-93.

 

To evaluate the efficacy and safety in the long term of a retreatment regimen with Rituximab (RTX) alone administered at clinical relapse in cryoglobulinemic vasculitis (CV).

Last Updated: 8 Sep 2015

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Bortezomib in type I cryoglobulinemic vasculitis: are we acting too late?
 

Author(s): Giuseppe A Ramirez, Corrado Campochiaro, Chiara Salmaggi, Gaia Pagliula, Teresa D'Aliberti, Magda Marcatti, Moreno Tresoldi, Luisa Praderio

Journal: Intern. Med.. 2015 ;54(9):1119-23.

 

Type II and type III cryoglobulinemic vasculitis (CV) are characterized by a deranged immune function due to concomitant chronic infections or rheumatic disorders. Conversely, type I CV is caused by plasma cell dyscrasia. Bortezomib is a proteasome inhibitor that is largely employed ...

Last Updated: 7 May 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cryoglobulinemic vasculitis" returned 3 free, full-text review articles on human participants. First 3 results:

HBV-associated cryoglobulinemic vasculitis: remission after antiviral therapy with entecavir.
 

Author(s): Mauro ViganĂ², Paul Martin, Mattia Cappelletti, Fabrizio Fabrizi

Journal: Kidney Blood Press. Res.. 2014 ;39(1):65-73.

 

Cryoglobulinemic vasculitis remains an uncommon complication of hepatitis B virus infection.

Last Updated: 18 Jul 2014

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Anti-CD20 monoclonal antibody (rituximab) treatment for cryoglobulinemic vasculitis: where do we stand?
 

Author(s): P Cacoub, A Delluc, D Saadoun, D A Landau, D Sene

Journal: Ann. Rheum. Dis.. 2008 Mar;67(3):283-7.

 

Mixed cryoglobulinemia (MC) vasculitis represents a complication of the B cell response to a variety of chronic inflammatory diseases. Recent reports describe the use of monoclonal antibodies directed to CD20 antigen (rituximab), a transmembrane protein expressed on pre-B lymphocytes ...

Last Updated: 22 Feb 2008

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Cryoglobulinemic vasculitis.
 

Author(s): P Lamprecht, A Gause, W L Gross

Journal: Arthritis Rheum.. 1999 Dec;42(12):2507-16.

 

Last Updated: 28 Jan 2000

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Vasculitis Pregnancy Registry
 

Status: Recruiting

Condition Summary: Vasculitis; Behcet's Disease; CNS Vasculitis; Cryoglobulinemic Vasculitis; Eosinophilic Granulomatosis With Polyangiitis (EGPA); Churg-Strauss Syndrome (CSS); Granulomatosis With Polyangiitis (GPA); Wegener's Granulomatosis; IgA Vasculitis; Henoch-Schoenlein Purpura (HSP); Microscopic Polyangiitis (MPA); Polyarteritis Nodosa (PAN); Takayasu Arteritis (TAK); Urticarial Vasculitis; Systemic Vasculitis

 

Last Updated: 27 Apr 2017

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Clinical Transcriptomics in Systemic Vasculitis (CUTIS)
 

Status: Recruiting

Condition Summary: Cryoglobulinemic Vasculitis (CV); Drug-induced Vasculitis; Eosinophilic Granulomatosis With Polyangiitis (EGPA); IgA Vasculitis; Isolated Cutaneous Vasculitis; Granulomatosis With Polyangiitis (GPA); Microscopic Polyangiitis (MPA); Polyarteritis Nodosa (PAN); Urticarial Vasculitis; Vasculitis

 

Last Updated: 24 Oct 2017

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