Cyanosis, transient neonatal

Common Name(s)

Cyanosis, transient neonatal

Neonatal cyanosis is characterized by symptoms in the fetus and neonate that gradually abate by 5 to 6 months of age. The disorder is caused by a defect in the fetal hemoglobin chain, which causes reduced affinity for oxygen due to steric inhibition of oxygen binding and/or due to increased oxidation of the fetal hemoglobin molecule to methemoglobin (Hb FM), which has decreased oxygen-binding capacity. Some patients develop anemia resulting from increased destruction of red cells containing abnormal or unstable hemoglobin. The cyanosis resolves spontaneously by 5 to 6 months of age or earlier, as the adult beta-globin chain (HBB; {141900}) is produced and replaces the fetal gamma-globin chain (summary by {1:Crowley et al., 2011}).
 

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Condition Specific Organizations

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Scientific Literature

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