Cyclic Neutropenia

Common Name(s)

Cyclic Neutropenia, Cyclic Hematopoiesis

Cyclic neutropenia is a rare blood disorder characterized by recurrent episodes of abnormally low levels of neutrophils (a type of white blood cell) in the body. Neutrophils are instrumental in fighting off infection by surrounding and destroying bacteria that enter the body. Symptoms of cyclic neutropenia may include fever, a general feeling of ill health, and/or sores (ulcers) of the mucous membranes of the mouth. Individuals with low levels of neutrophils (neutropenia) are highly susceptible to recurrent infections. Cyclic neutropenia may be inherited or acquired. Some cases are present at birth and appear to occur randomly for no apparent reason (sporadic). Inherited cases appear to be transmitted in an autosomal dominant fashion and caused by mutations in the ELANE gene.
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Advocacy and Support Organizations Health Questions Recommended Apps Scientific Literature Symptoms, Diagnosis, and Treatment Clinical Trial Information
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cyclic Neutropenia" for support, advocacy or research.

National Neutropenia Network Inc.

To promote awareness, education, and research, and to provide a support system for patients with severe chronic neutropenia and their families through a national resource network.

Last Updated: 29 Apr 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Cyclic Neutropenia" for support, advocacy or research.

National Neutropenia Network Inc.

To promote awareness, education, and research, and to provide a support system for patients with severe chronic neutropenia and their families through a national resource network.

http://www.neutropenianet.org/

Last Updated: 29 Apr 2014

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General Support Organizations

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Recommended Apps

Privately answer questions about your health. Let resources, you select, come to you

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

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Relief is when you and the right researcher find each other

Finding the right clinical trial for Cyclic Neutropenia can be challenging. However, with TrialsFinder (which uses the Reg4ALL database and privacy controls by Private Access), you can permit researchers to let you know opportunities to consider - all without revealing your identity.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Cyclic Neutropenia" returned 50 free, full-text research articles on human participants. First 3 results:

ELANE gene mutation-induced cyclic neutropenia manifesting as recurrent fever with oral mucosal ulcer: A case report.
 

Author(s): Xin Chen, Wansheng Peng, Zhen Zhang, Yumeng Wu, Jiali Xu, Yan Zhou, Li Chen

Journal: Medicine (Baltimore). 2018 Mar;97(10):e0031.

 

Cyclic neutropenia (CyN) is a rare hematological disease. Herein, a CyN girl, aged 3 years and 2 months, with recurrent fever and oral mucosal ulcer caused by neutrophil elastase (ELANE) gene mutation is reported.

Last Updated: 31 Dec 1969

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Long-Term Effects of G-CSF Therapy in Cyclic Neutropenia.
 

Author(s): David C Dale, AudreyAnna Bolyard, Tracy Marrero, Vahagn Makaryan, MaryAnn Bonilla, Daniel C Link, Peter Newburger, Akiko Shimamura, Laurence A Boxer, Charles Spiekerman

Journal: N. Engl. J. Med.. 2017 12;377(23):2290-2292.

 

Last Updated: 31 Dec 1969

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Giant Cell Arteritis which Developed after the Administration of Granulocyte-colony Stimulating Factor for Cyclic Neutropenia.
 

Author(s): Masataka Umeda, Jin Ikenaga, Tomohiro Koga, Toru Michitsuji, Toshimasa Shimizu, Shoichi Fukui, Ayako Nishino, Yoshikazu Nakasima, Sin-Ya Kawashiri, Naoki Iwamoto, Kunihiro Ichinose, Yasuko Hirai, Mami Tamai, Hideki Nakamura, Tomoki Origuchi, Atsushi Kawakami

Journal: Intern. Med.. 2016 ;55(16):2291-4.

 

A 78-year-old woman diagnosed with cyclic neutropenia 5 years previously had been treated with recombinant granulocyte-colony stimulating factor (G-CSF). She developed fever, tenderness and distension of temporal arteries after the treatment with G-CSF. Magnetic resonance imaging ...

Last Updated: 31 Dec 1969

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To view other free, full-text articles on human participants, please click on the link below.

PubMed Article Results at NCBI: 50 article(s)

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Cyclic Neutropenia" returned 3 free, full-text review articles on human participants. First 3 results:

ELANE mutations in cyclic and severe congenital neutropenia: genetics and pathophysiology.
 

Author(s): Marshall S Horwitz, Seth J Corey, H Leighton Grimes, Timothy Tidwell

Journal: Hematol. Oncol. Clin. North Am.. 2013 Feb;27(1):19-41, vii.

 

The 2 main forms of hereditary neutropenia are cyclic (CN) and severe congenital (SCN) neutropenia. CN is an autosomal dominant disorder in which neutrophil counts fluctuate with 21-day periodicity. SCN consists of static neutropenia, with promyelocytic maturation arrest in the bone ...

Last Updated: 31 Dec 1969

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Neutrophil elastase in cyclic and severe congenital neutropenia.
 

Author(s): Marshall S Horwitz, Zhijun Duan, Brice Korkmaz, Hu-Hui Lee, Matthew E Mealiffe, Stephen J Salipante

Journal: Blood. 2007 Mar;109(5):1817-24.

 

Mutations in ELA2 encoding the neutrophil granule protease, neutrophil elastase (NE), are the major cause of the 2 main forms of hereditary neutropenia, cyclic neutropenia and severe congenital neutropenia (SCN). Genetic evaluation of other forms of neutropenia in humans and model ...

Last Updated: 31 Dec 1969

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A patient with cyclic neutropenia complicated by severe persistent neutropenia successfully delivered a healthy baby.
 

Author(s): T Abe, H Azuma, A Watanabe, T Shigekiyo, S Endou, R Pou, R Fukui, K Maeda, T Aono, T Matsumoto

Journal: Intern. Med.. 2000 Aug;39(8):663-6.

 

We describe a 24-year-old pregnant woman complicated by cyclic neutropenia (CN), who was successfully treated with granulocyte-colony stimulating factor (G-CSF). Her white blood cell (WBC) and neutrophil count fluctuated from 2,600 to 4,600/microl, and 26 to 2,530/microl, respectively. ...

Last Updated: 31 Dec 1969

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To view other free, full-text review articles on human participants, please click on the link below.

PubMed Review Results at NCBI: 3 review(s)

 
 
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Symptoms, Diagnosis, and Treatment

This information is provided by Genetics Home Reference.
https://ghr.nlm.nih.gov/condition/cyclic-neutropenia
https://ghr.nlm.nih.gov/gene/ELANE
https://ghr.nlm.nih.gov/gene/C8orf34
https://ghr.nlm.nih.gov/condition/cyclic-vomiting-syndrome
https://ghr.nlm.nih.gov/condition/severe-congenital-neutropenia
https://ghr.nlm.nih.gov/condition/poikiloderma-with-neutropenia
https://ghr.nlm.nih.gov/gene/HAX1
https://ghr.nlm.nih.gov/gene/PDE10A
https://ghr.nlm.nih.gov/condition/barth-syndrome
https://ghr.nlm.nih.gov/gene/GFI1
https://ghr.nlm.nih.gov/gene/PDE11A
https://ghr.nlm.nih.gov/gene/PDE3A
https://ghr.nlm.nih.gov/gene/HCN4
https://ghr.nlm.nih.gov/gene/DDX41
https://ghr.nlm.nih.gov/gene/JAGN1
https://ghr.nlm.nih.gov/gene/MFAP5
https://ghr.nlm.nih.gov/gene/G6PC3
https://ghr.nlm.nih.gov/gene/PDE4D
https://ghr.nlm.nih.gov/gene/PRKACG
https://ghr.nlm.nih.gov/gene/CSF3R
Full Results at Genetics Home Reference: 70 matches
This information is provided by GeneReviews.
http://www.ncbi.nlm.nih.gov/books/NBK1533
This information is provided by Genetic Testing Registry.
http://www.ncbi.nlm.nih.gov/gtr/conditions/C0221023
 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Randomized Phase 2, Dose-finding Efficacy, Safety Study of ANF-RHO™ Versus Neulasta® in Chemotherapy-Induced Neutropenia
 

Status: Recruiting

Condition Summary: Chemotherapy-induced Neutropenia

 

Last Updated: 5 Jun 2018

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According to ClinicalTrials.gov there are currently 0 additional "open" studies for "Cyclic Neutropenia" (open studies are recruiting volunteers) and 10 "Cyclic Neutropenia" studies with "all" status. Visit ClinicalTrials.gov now to view them. Or alternatively, consider TrialsFinder for assistance:
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Relief is when you and the right researcher find each other
Finding the right clinical trial for Cyclic Neutropenia can be challenging. However, with TrialsFinder (which uses the Reg4ALL database and privacy controls by Private Access), you can permit researchers to let you know opportunities to consider - all without revealing your identity.
Learn More