Delleman-Oorthuys syndrome, also known as oculocerebrocutaneous syndrome (OCCS) or Leichtman-Wood-Rohn syndrome, is a rare set of birth defects, or a syndrome. This syndrome is characterized by intellectual disabilities, and eye, central nervous system (CNS), and skin malformations or defects. Signs and symptoms may include: orbital cysts (pockets of gas/liquid in the eye socket), muscle hamartomas (noncancerous tumors), and seizures. This condition has been seen in 35 people, and is more common in males. Treatment varies on a case-by-case basis, for example, doctors can seek help from various therapists and community services to provide support and care for families affected by intellectual disability, or surgery may be required to remove orbital cysts. Delleman-oorthuys syndrome has been fatal in 14% of observed cases.