Demyelinating Diseases

Common Name(s)

Demyelinating Diseases, Hypomyelination

Demyelinating diseases are conditions resulting in damage to brain or nerves, which connects the muscles to the brain to create movement. These disorders specifically affect the protective covering that surrounds nerve fibers consequently causing neurological problems. Symptoms vary according to the disease location, however seizures, headaches, delirium, confusion or slurred speech most commonly occur. Some may also experience pain, numbness, vision, hearing, or bladder problems. Diagnostic tests vary depending on the specific condition, however most demyelinating diseases can be identified from a brain scan and nerve test. No cures exist for demyelinating diseases; the goal of treatment is management of symptoms. Treatment will often include medications and occupational ot physical therapy if needed.

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Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Demyelinating Diseases" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Demyelinating Diseases" returned 30 free, full-text research articles on human participants. First 3 results:

Vascular hypoperfusion in acute optic neuritis is a potentially new neurovascular model for demyelinating diseases.
 

Author(s): Ta-Ching Chen, Chao-Yuan Yeh, Chao-Wen Lin, Chung-May Yang, Chang-Hao Yang, I-Hung Lin, Pao-Yang Chen, Jung-Yu Cheng, Fung-Rong Hu

Journal:

 

Optic neuritis is highly correlated with multiple sclerosis and is a major cause of acute visual loss and long-term neuronal degeneration. Primary cerebral hypoperfusion has been reported in brain demyelinating diseases. This study investigated whether peripapillary perfusion is changed ...

Last Updated: 31 Dec 1969

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Demyelinating diseases as a result of cerebral edema?
 

Author(s): Helmut Barz, Almut Schreiber, Ulrich Barz

Journal: Med. Hypotheses. 2017 Jul;104():10-14.

 

Due to the elastic properties of the human organs, tissue edema causes an increased tissue pressure. This phenomenon leads to a reduction of blood circulation or ischemia, and thus leads to the hypothesis that tissue edema can be the cause of demyelinating lesions. Even though brain ...

Last Updated: 31 Dec 1969

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Automated Radiochemical Synthesis of [18F]3F4AP: A Novel PET Tracer for Imaging Demyelinating Diseases.
 

Author(s): Pedro Brugarolas, Mohammed Bhuiyan, Anna Kucharski, Richard Freifelder

Journal:

 

3-[F]fluoro-4-aminopyridine, [F]3F4AP, is a radiofluorinated analog of the FDA-approved drug for multiple sclerosis 4-aminopyridine (4AP). This compound is currently under investigation as a PET tracer for demyelination. We recently described a novel chemical reaction to produce metafluorinated ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Demyelinating Diseases" returned 16 free, full-text review articles on human participants. First 3 results:

Multiple cerebral gliomas mimicking central nervous system inflammatory demyelinating diseases: A rare case with review of literature.
 

Author(s): Yong-Jie Xiong, Xin-Ling Zhao, Xiao-Yan Wang, Deng-Ji Pan, Dai-Shi Tian

Journal: Medicine (Baltimore). 2017 Dec;96(52):e9456.

 

Multiple cerebral gliomas (MCGs), usually classified into multifocal and multicentric subtypes, represent major diagnostic challenges as their clinical, radiologic, and pathohistological features are not uniform, often mimicking brain metastatic tumors or central nervous system inflammatory ...

Last Updated: 31 Dec 1969

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Cerebrospinal fluid data compilation and knowledge-based interpretation of bacterial, viral, parasitic, oncological, chronic inflammatory and demyelinating diseases. Diagnostic patterns not to be missed in neurology and psychiatry.
 

Author(s): Hansotto Reiber

Journal: Arq Neuropsiquiatr. 2016 Apr;74(4):337-50.

 

The analysis of intrathecal IgG, IgA and IgM synthesis in cerebrospinal fluid (CSF) and evaluation in combined quotient diagrams provides disease-related patterns. The compilation with complementary parameters (barrier function, i.e., CSF flow rate, cytology, lactate, antibodies) ...

Last Updated: 31 Dec 1969

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Physiological Dynamics in Demyelinating Diseases: Unraveling Complex Relationships through Computer Modeling.
 

Author(s): Jay S Coggan, Stefan Bittner, Klaus M Stiefel, Sven G Meuth, Steven A Prescott

Journal:

 

Despite intense research, few treatments are available for most neurological disorders. Demyelinating diseases are no exception. This is perhaps not surprising considering the multifactorial nature of these diseases, which involve complex interactions between immune system cells, ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Contrast-enhanced 3D T1-weighted Gradient-echo Versus Spin-echo 3 Tesla MR Sequences in the Detection of Active Multiple Sclerosis Lesions
 

Status: Recruiting

Condition Summary: Magnetic Resonance Imaging; Central Nervous System; Brain; Multiple Sclerosis; Demyelinating Diseases

 

Last Updated: 7 Feb 2018

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BN201 SAD MAD Study in Healthy Subjects
 

Status: Recruiting

Condition Summary: Optic Neuritis; Optic; Neuritis, With Demyelination

 

Last Updated: 10 Aug 2018

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