Dengue

Common Name(s)

Dengue, Dengue virus, susceptibility to

Dengue is a virus that is carried by mosquitos and affects over 100 million people worldwide each year. The virus is passed to humans through mosquito bites. Those who inhabit or visit tropical or sub-tropical regions, particularly in urban or suburban areas, are most at risk for infection. Symptoms of Dengue include a high fever, intense headache or aching behind the eyes, joint pain, easy bruising, gum or nose bleeds, bone and muscle pain, swollen glands, and a rash. Symptoms usually appear 4-10 days after infection and last for 2-7 days.

There are four types of dengue virus: DEN-1, DEN-2, DEN-3, and DEN-4. Once an individual has recovered from one of these types, that individual will not develop symptoms from that same type again. When an individual is infected by a different type, however, there is a risk for severe dengue. Symptoms of severe dengue include vomiting (sometimes bloody), tiredness, severe stomach pain, fast breathing, restlessness, and bleeding gums. These symptoms occur after the high fever of dengue has dropped. Severe dengue requires immediate treatment, as it can cause the liquid part of the blood (plasma) to leak from small blood vessels (capillaries). This condition leads to severe loss of blood volume (shock) and can be life-threatening. Other complications may include internal bleeding, difficulty breathing, and accumulation of fluid in the body.

Severe dengue is treated by fluid replacement therapy. Dengue prevention methods focus on avoiding mosquitos, such as by getting rid of stagnant water in containers where mosquitos lay eggs and using bed nets during the night and mosquito repellant when outdoors. If you have been diagnosed with dengue, talk to your doctor about current treatment options. In addition, consult a medical professional for advice before traveling to areas where there is a potential to be infected by the dengue virus.

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Advocacy and Support Organizations

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Dengue" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Dengue" returned 3713 free, full-text research articles on human participants. First 3 results:

MicroRNA profiling of human primary macrophages exposed to dengue virus identifies miRNA-3614-5p as antiviral and regulator of ADAR1 expression.
 

Author(s): Mayra Diosa-Toro, Liliana Echavarría-Consuegra, Jacky Flipse, Geysson Javier Fernández, Joost Kluiver, Anke van den Berg, Silvio Urcuqui-Inchima, Jolanda M Smit

Journal:

 

Due to the high burden of dengue disease worldwide, a better understanding of the interactions between dengue virus (DENV) and its human host cells is of the utmost importance. Although microRNAs modulate the outcome of several viral infections, their contribution to DENV replication ...

Last Updated: 18 Oct 2017

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Developing a dengue forecast model using machine learning: A case study in China.
 

Author(s): Pi Guo, Tao Liu, Qin Zhang, Li Wang, Jianpeng Xiao, Qingying Zhang, Ganfeng Luo, Zhihao Li, Jianfeng He, Yonghui Zhang, Wenjun Ma

Journal:

 

In China, dengue remains an important public health issue with expanded areas and increased incidence recently. Accurate and timely forecasts of dengue incidence in China are still lacking. We aimed to use the state-of-the-art machine learning algorithms to develop an accurate predictive ...

Last Updated: 16 Oct 2017

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Human macrophages differentiated in the presence of vitamin D3 restrict dengue virus infection and innate responses by downregulating mannose receptor expression.
 

Author(s): John F Arboleda Alzate, Izabela A Rodenhuis-Zybert, Juan C Hernández, Jolanda M Smit, Silvio Urcuqui-Inchima

Journal:

 

Severe dengue disease is associated with high viral loads and overproduction of pro-inflammatory cytokines, suggesting impairment in the control of dengue virus (DENV) and the mechanisms that regulate cytokine production. Vitamin D3 has been described as an important modulator of ...

Last Updated: 11 Oct 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Dengue" returned 286 free, full-text review articles on human participants. First 3 results:

Community effectiveness of indoor spraying as a dengue vector control method: A systematic review.
 

Author(s): Moody Samuel, Dorit Maoz, Pablo Manrique, Tara Ward, Silvia Runge-Ranzinger, Joao Toledo, Ross Boyce, Olaf Horstick

Journal:

 

The prevention and control of dengue rely mainly on vector control methods, including indoor residual spraying (IRS) and indoor space spraying (ISS). This study aimed to systematically review the available evidence on community effectiveness of indoor spraying.

Last Updated: 31 Aug 2017

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ANTI-VIRAL EFFECTS OF MEDICINAL PLANTS IN THE MANAGEMENT OF DENGUE: A SYSTEMATIC REVIEW.
 

Author(s): Éric Heleno Freira Ferreira Frederico, André Luiz Bandeira Dionísio Cardoso, Eloá Moreira-Marconi, Danúbia da Cunha de Sá-Caputo, Carlos Alberto Sampaio Guimarães, Carla da Fontoura Dionello, Danielle Soares Morel, Laisa Liane Paineiras-Domingos, Patricia Lopes de Souza, Samuel Brandão-Sobrinho-Neto, Rafaelle Pacheco Carvalho-Lima, Eliane de Oliveira Guedes-Aguiar, Rebeca Graça Costa-Cavalcanti, Cristiane Ribeiro Kutter, Mario Bernardo-Filho

Journal:

 

Dengue is considered as an important arboviral disease. Safe, low-cost, and effective drugs that possess inhibitory activity against dengue virus (DENV) are mostly needed to try to combat the dengue infection worldwide. Medicinal plants have been considered as an important alternative ...

Last Updated: 25 Jul 2017

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Community effectiveness of pyriproxyfen as a dengue vector control method: A systematic review.
 

Author(s): Dorit Maoz, Tara Ward, Moody Samuel, Pie Müller, Silvia Runge-Ranzinger, Joao Toledo, Ross Boyce, Raman Velayudhan, Olaf Horstick

Journal:

 

Vector control is the only widely utilised method for primary prevention and control of dengue. The use of pyriproxyfen may be promising, and autodissemination approach may reach hard to reach breeding places. It offers a unique mode of action (juvenile hormone mimic) and as an additional ...

Last Updated: 17 Jul 2017

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

The Use of Biomarkers in Predicting Dengue Outcome
 

Status: Recruiting

Condition Summary: Dengue

 

Last Updated: 24 Oct 2016

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