Diabetic gastroparesis

Common Name(s)

Diabetic gastroparesis

Diabetic gastroparesis is a condition in which the stomach muscles do not work correctly. When food moves into the stomach, muscles contract and relax to break down the food before it passes into the small intestine. If the stomach muscles do not work correctly, food does not move on to the small intestine, causing problems with digestion. Diabetic gastroparesis is caused by complications of diabetes.

Symptoms of diabetic gastroparesis include vomiting, nausea, feeling full after just a few bites, bloating, abdominal pain, lack of appetite, malnutrition, and changes in blood sugar levels. Complications include severe dehydration and malnutrition. Gastroparesis also makes it more difficult for blood sugar levels to be controlled. The cause of gastroparesis seems to involve damage to the nerve that controls stomach muscles (the vagus nerve), which can be damaged by diabetes.

Diabetic gastroparesis may affect people with either type 1 or type 2 diabetes. If blood sugar or glucose levels remain high for a long period of time, diabetes may damage the vagus nerve. High sugar or glucose causes chemical changes in nerves and damages the blood vessels that carry oxygen and nutrients to the nerves.

Diagnosis may include and upper GI scan, MRI, CT scan, special breath test, stomach emptying test and/or an endoscopy. The most important treatment for diabetic gastroparesis is to get blood sugar levels under control. Treatment for symptoms of gastroparesis may include diet changes, medication, and/or devices or procedures that help move the digested food through the stomach but there is no cure. If you or a family member has been diagnosed with gastroparesis, talk to your doctor and specialists about the most current treatment options. Support groups are a good source for information and will help connect you with others living with gastroparesis.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Diabetic gastroparesis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Diabetic gastroparesis" returned 45 free, full-text research articles on human participants. First 3 results:

Repeat polymorphisms in the Homo sapiens heme oxygenase-1 gene in diabetic and idiopathic gastroparesis.
 

Author(s): Simon J Gibbons, Madhusudan Grover, Kyoung Moo Choi, Akhilesh Wadhwa, Adeel Zubair, Laura A Wilson, Yanhong Wu, Thomas L Abell, William L Hasler, Kenneth L Koch, Richard W McCallum, Linda A B Nguyen, Henry P Parkman, Irene Sarosiek, William J Snape, James Tonascia, Frank A Hamilton, Pankaj J Pasricha, Gianrico Farrugia

Journal:

 

Idiopathic and diabetic gastroparesis in Homo sapiens cause significant morbidity. Etiology or risk factors have not been clearly identified. Failure to sustain elevated heme oxygenase-1 (HO1) expression is associated with delayed gastric emptying in diabetic mice and polymorphisms ...

Last Updated: 31 Dec 1969

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Exploring the Diabetic Gastroparesis Patient Experience: Patient Exit Interviews.
 

Author(s): Claire M Ervin, David S Reasner, Jennifer T Hanlon, Sheri E Fehnel

Journal: Adv Ther. 2017 Dec;34(12):2680-2692.

 

To improve understanding of the diabetic gastroparesis (DGP) patient experience and inform the patient-reported outcome measurement strategy for future trials in DGP, qualitative interviews were conducted with participants in a phase 2 clinical trial of a novel DGP treatment.

Last Updated: 31 Dec 1969

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Impaired insulin/IGF-1 is responsible for diabetic gastroparesis by damaging myenteric cholinergic neurones and interstitial cells of Cajal.
 

Author(s): Shu Yang, Bo Wu, Haimei Sun, Tingyi Sun, Kai Han, Dandan Li, Fengqing Ji, Guoquan Zhang, Deshan Zhou

Journal:

 

Diabetic gastroparesis is a common complication of diabetes mellitus (DM) that is characterized by decreased serum insulin and insulin-like growth factor-1 (IGF-1). Despite the fact that insulin treatment not glycemic control potently accelerated gastric emptying in type 1 DM patients, ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Diabetic gastroparesis" returned 10 free, full-text review articles on human participants. First 3 results:

Histologic changes in diabetic gastroparesis.
 

Author(s): Gianrico Farrugia

Journal: Gastroenterol. Clin. North Am.. 2015 Mar;44(1):31-8.

 

The cellular abnormalities that lead to diabetic gastroparesis are increasingly being understood. Several key cell types are affected by diabetes, leading to gastroparesis. These changes include abnormalities in the extrinsic innervation to the stomach, loss of key neurotransmitters ...

Last Updated: 31 Dec 1969

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Macrophages in diabetic gastroparesis--the missing link?
 

Author(s): L Neshatian, S J Gibbons, G Farrugia

Journal: Neurogastroenterol. Motil.. 2015 Jan;27(1):7-18.

 

Diabetic gastroparesis results in significant morbidity for patients and major economic burden for society. Treatment options for diabetic gastroparesis are currently directed at symptom control rather than the underlying disease and are limited. The pathophysiology of diabetic gastroparesis ...

Last Updated: 31 Dec 1969

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Treatment of refractory diabetic gastroparesis: Western medicine and traditional Chinese medicine therapies.
 

Author(s): Bing Pang, Qiang Zhou, Jun-Ling Li, Lin-Hua Zhao, Xiao-Lin Tong

Journal: World J. Gastroenterol.. 2014 Jun;20(21):6504-14.

 

Refractory diabetic gastroparesis (DGP), a disorder that occurs in both type 1 and type 2 diabetics, is associated with severe symptoms, such as nausea and vomiting, and results in an economic burden on the health care system. In this article, the basic characteristics of refractory ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Docusate/Senna for the Treatment of Diabetic Gastroparesis
 

Status: Recruiting

Condition Summary: Diabetic Gastroparesis

 

Last Updated: 3 Apr 2018

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Evaluation of Diagnostic Methods and Dietary Treatment of Diabetic Gastroparesis
 

Status: Recruiting

Condition Summary: Diabetic Gastroparesis

 

Last Updated: 20 Feb 2018

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A Study to Evaluate the Efficacy and Safety of TAK-906 in Adult Participants With Symptomatic Idiopathic or Diabetic Gastroparesis
 

Status: Not yet recruiting

Condition Summary: Diabetic Gastroparesis; Idiopathic Gastroparesis

 

Last Updated: 21 May 2018

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