Dyspepsia

Common Name(s)

Dyspepsia, Indigestion

Dyspepsia is discomfort or pain from the upper digestive tract, also known as indigestion. This discomfort may be originating from the stomach, throat, or upper intestine. Common symptoms of dyspepsia include bloating, nausea, loss of appetite, a burning sensation, regurgitation, and burping. Dyspepsia without the presence of another gastrointestinal (GI) condition is known as functional dyspepsia. Dyspepsia is very common and affects 15% of the Western population.

Dyspepsia may be caused by another GI condition or may be caused by specific food sensitivities or stressors. Potential causes include disorders in the movement of food through the upper GI tract, the presence of ulcers, and acid reflux disease. Certain foods, such as lactose in those who are lactose intolerant, caffeine, alcohol, or oral medications may also cause dyspepsia. Stomach or duodenal ulcers may cause dyspepsia. Depression, anxiety, and increased stress may also cause dyspepsia.

Treatment is often dependent upon the specific cause of the dyspepsia. Dietary changes such as avoidance of the foods that cause symptoms is often suggested. Behavioral changes such as eating frequent, smaller meals rather than three large meals, and not lying down after eating may also alleviate symptoms. Refraining from smoking or wearing tight fitting clothes may be beneficial, as well as maintaining a healthy body weight. Medications to decrease stomach acid or pain may also be used. Certain anti-inflammatory medications, such as ibuprofen, may cause damage to the lining of the stomach and should be minimized or avoided in individuals with dyspepsia. If you are suffering from dyspepsia, talk to your doctor about the most current treatment options.

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Condition Specific Organizations

Following organizations serve the condition "Dyspepsia" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Dyspepsia" returned 645 free, full-text research articles on human participants. First 3 results:

Factors leading to dyspepsia in renal transplant recipients.
 

Author(s): Aisha Nazeer, Ayesha Aslam Rai, Nasir Hassan Luck

Journal:

 

Renal transplantation is the definitive treatment for end stage renal disease. Patients subjected to transplantation require lifelong immunosuppression and are prone to several gastrointestinal disorders. Dyspepsia is a common disorder in these patients. The objective of this study ...

Last Updated: 31 Dec 1969

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Effect of Zhizhu Kuanzhong capsule on functional dyspepsia: Protocol for a systematic review and meta-analysis of randomized controlled trials.
 

Author(s): Haixiong Lin, Xiaotong Wang, Xiuting Du, Junyue Wang, Yusi Li, Ren Zhang

Journal: Medicine (Baltimore). 2018 Feb;97(6):e9731.

 

Functional dyspepsia (FD) is a gastrointestinal disorder affecting people in the globe. Spleen-deficiency syndrome is one of its basic syndromes. Zhizhu Kuanzhong capsule was the most frequent Chinese herbal formula used in the spleen-deficiency researches. We aim to assess the effectiveness ...

Last Updated: 31 Dec 1969

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Pattern of presentation of gastroesophageal reflux disease among patients with dyspepsia in Kano, Nigeria.
 

Author(s): Abubakar Sadiq Maiyaki, Musa Muhammed Borodo, Adamu Alhaji Samaila, Abdulmumini Yakubu

Journal: Ann Afr Med. ;16(4):159-163.

 

Dyspepsia is a symptom complex rather than a specific disease entity. It can be caused by both organic and functional gastrointestinal (GI) disorders. Gastroesophageal reflux disease (GORD) though a common digestive disorder worldwide is scarcely reported in Nigeria. The aim of this ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Dyspepsia" returned 107 free, full-text review articles on human participants. First 3 results:

Functional Dyspepsia: Advances in Diagnosis and Therapy.
 

Author(s): Nicholas J Talley

Journal: Gut Liver. 2017 May;11(3):349-357.

 

Functional dyspepsia (FD) is a common but under-recognized syndrome comprising bothersome recurrent postprandial fullness, early satiety, or epigastric pain/burning. Epidemiologically, there are two clinically distinct FD syndromes (although these often overlap clinically): postprandial ...

Last Updated: 31 Dec 1969

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Effect of Chinese patent medicine Si-Mo-Tang oral liquid for functional dyspepsia: A systematic review and meta-analysis of randomized controlled trials.
 

Author(s): Yunxia Hu, Yu Bai, Zhiyun Hua, Jie Yang, Huahui Yang, Wenjun Chen, Junwei Xu, Zhiqiang Zhao

Journal:

 

Si-Mo-Tang oral liquid (SMT) has been widely used to treat functional dyspepsia (FD), but the effectiveness is still controversial. A systematic review and meta-analysis of randomized controlled trials (RCTs) were performed to assess the efficacy and adverse effects of SMT for FD.

Last Updated: 31 Dec 1969

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[Current Status of Translational Research on Functional Dyspepsia].
 

Author(s): Jae Ho Park, Jong Wook Kim, Jong Kyu Park, Cheol Min Shin, Kee Wook Jung

Journal: Korean J Gastroenterol. 2016 Sep;68(3):132-7.

 

Functional dyspepsia (FD) has a diverse pathophysiology and treatment is difficult. Translational research to understand its pathophysiology is underway. Hormonal factors, including ghrelin, seem promising, offering an understanding of appetite and eating. Functional MRI brain study ...

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

The Predictive Value of Alarm Symptoms in Patients With Dyspepsia Based on Roman IV
 

Status: Recruiting

Condition Summary: Dyspepsia

 

Last Updated: 31 Mar 2018

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Efficacy of Bromopride and Simethicone Versus Bromopride in Functional Dyspepsia
 

Status: Recruiting

Condition Summary: Dyspepsia

 

Last Updated: 3 Jan 2018

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Effectiveness of tDCS for the Treatment of Functional Dyspepsia
 

Status: Recruiting

Condition Summary: Dyspepsia

 

Last Updated: 17 May 2016

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