Dyspepsia

Common Name(s)

Dyspepsia, Indigestion

Dyspepsia is discomfort or pain from the upper digestive tract, also known as indigestion. This discomfort may be originating from the stomach, throat, or upper intestine. Common symptoms of dyspepsia include bloating, nausea, loss of appetite, a burning sensation, regurgitation, and burping. Dyspepsia without the presence of another gastrointestinal (GI) condition is known as functional dyspepsia. Dyspepsia is very common and affects 15% of the Western population.

Dyspepsia may be caused by another GI condition or may be caused by specific food sensitivities or stressors. Potential causes include disorders in the movement of food through the upper GI tract, the presence of ulcers, and acid reflux disease. Certain foods, such as lactose in those who are lactose intolerant, caffeine, alcohol, or oral medications may also cause dyspepsia. Stomach or duodenal ulcers may cause dyspepsia. Depression, anxiety, and increased stress may also cause dyspepsia.

Treatment is often dependent upon the specific cause of the dyspepsia. Dietary changes such as avoidance of the foods that cause symptoms is often suggested. Behavioral changes such as eating frequent, smaller meals rather than three large meals, and not lying down after eating may also alleviate symptoms. Refraining from smoking or wearing tight fitting clothes may be beneficial, as well as maintaining a healthy body weight. Medications to decrease stomach acid or pain may also be used. Certain anti-inflammatory medications, such as ibuprofen, may cause damage to the lining of the stomach and should be minimized or avoided in individuals with dyspepsia. If you are suffering from dyspepsia, talk to your doctor about the most current treatment options.

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Condition Specific Organizations

Following organizations serve the condition "Dyspepsia" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Dyspepsia" returned 660 free, full-text research articles on human participants. First 3 results:

Factors leading to dyspepsia in renal transplant recipients.
 

Author(s): Aisha Nazeer, Ayesha Aslam Rai, Nasir Hassan Luck

Journal:

 

Renal transplantation is the definitive treatment for end stage renal disease. Patients subjected to transplantation require lifelong immunosuppression and are prone to several gastrointestinal disorders. Dyspepsia is a common disorder in these patients. The objective of this study ...

Last Updated: 31 Dec 1969

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Effect of Zhizhu Kuanzhong capsule on functional dyspepsia: Protocol for a systematic review and meta-analysis of randomized controlled trials.
 

Author(s): Haixiong Lin, Xiaotong Wang, Xiuting Du, Junyue Wang, Yusi Li, Ren Zhang

Journal: Medicine (Baltimore). 2018 Feb;97(6):e9731.

 

Functional dyspepsia (FD) is a gastrointestinal disorder affecting people in the globe. Spleen-deficiency syndrome is one of its basic syndromes. Zhizhu Kuanzhong capsule was the most frequent Chinese herbal formula used in the spleen-deficiency researches. We aim to assess the effectiveness ...

Last Updated: 31 Dec 1969

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A Prospective, randomized study comparing 7-day and 14-day quadruple therapies as first-line treatments for helicobacter pylori infection in patients with functional dyspepsia.
 

Author(s): A Yagbasan, D Ö Coşkun, Ö Özbakir, K Deniz, Ş Gürsoy, M Yücesoy

Journal: Niger J Clin Pract. 2018 Jan;21(1):54-58.

 

Standard triple therapy for Helicobacter pylori has a low eradication rate in Turkey. The aim of this study was to evaluate and compare the effectiveness of 7-day and 14-day lansoprazole, amoxicillin, clarithromycin, and bismuth subsalicylate (LACB) treatment regimens as first-line ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Dyspepsia" returned 110 free, full-text review articles on human participants. First 3 results:

Functional Dyspepsia and Irritable Bowel Syndrome: Beyond Rome IV.
 

Author(s): Vincenzo Stanghellini

Journal: Dig Dis. 2017 ;35 Suppl 1():14-17.

 

The correct diagnosis of functional gastrointestinal disorders (FGIDs) is quite a challenge. The overlaps between syndromes can complicate the interpretation of clinical data.

Last Updated: 31 Dec 1969

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Mechanism of Action of STW 5 in Functional Dyspepsia and IBS: The Origin of Multi-Target.
 

Author(s): Hans-Dieter Allescher, Heba Abdel-Aziz

Journal: Dig Dis. 2017 ;35 Suppl 1():18-24.

 

STW 5 is a complex herbal combination preparation composed of 9 different herbal extracts. As an herbal medicinal product, this preparation is indicated for treating functional dyspepsia (FD) and irritable bowel syndrome (IBS). Its efficacy and practical applicability was demonstrated ...

Last Updated: 31 Dec 1969

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A Systematic Review of the Effectiveness of Antianxiety and Antidepressive Agents for Functional Dyspepsia.
 

Author(s): Mariko Hojo, Akihito Nagahara, Daisuke Asaoka, Yuji Shimada, Hitoshi Sasaki, Kohei Matsumoto, Tsutomu Takeda, Hiroya Ueyama, Kenshi Matsumoto, Sumio Watanabe

Journal: Intern. Med.. 2017 Dec;56(23):3127-3133.

 

Objective Functional dyspepsia (FD) is defined as persistent or recurrent pain or discomfort centered in the upper abdomen without organic disease. Psychosocial factors have been proposed as an important element in the pathophysiology of FD. Therefore, psychotropic agents having antianxiety ...

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

The Predictive Value of Alarm Symptoms in Patients With Dyspepsia Based on Roman IV
 

Status: Recruiting

Condition Summary: Dyspepsia

 

Last Updated: 13 Jun 2018

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Efficacy of Bromopride and Simethicone Versus Bromopride in Functional Dyspepsia
 

Status: Recruiting

Condition Summary: Dyspepsia

 

Last Updated: 3 Jan 2018

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Effectiveness of tDCS for the Treatment of Functional Dyspepsia
 

Status: Recruiting

Condition Summary: Dyspepsia

 

Last Updated: 17 May 2016

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