Dyspepsia

Common Name(s)

Dyspepsia, Indigestion

Dyspepsia is discomfort or pain from the upper digestive tract, also known as indigestion. This discomfort may be originating from the stomach, throat, or upper intestine. Common symptoms of dyspepsia include bloating, nausea, loss of appetite, a burning sensation, regurgitation, and burping. Dyspepsia without the presence of another gastrointestinal (GI) condition is known as functional dyspepsia. Dyspepsia is very common and affects 15% of the Western population.

Dyspepsia may be caused by another GI condition or may be caused by specific food sensitivities or stressors. Potential causes include disorders in the movement of food through the upper GI tract, the presence of ulcers, and acid reflux disease. Certain foods, such as lactose in those who are lactose intolerant, caffeine, alcohol, or oral medications may also cause dyspepsia. Stomach or duodenal ulcers may cause dyspepsia. Depression, anxiety, and increased stress may also cause dyspepsia.

Treatment is often dependent upon the specific cause of the dyspepsia. Dietary changes such as avoidance of the foods that cause symptoms is often suggested. Behavioral changes such as eating frequent, smaller meals rather than three large meals, and not lying down after eating may also alleviate symptoms. Refraining from smoking or wearing tight fitting clothes may be beneficial, as well as maintaining a healthy body weight. Medications to decrease stomach acid or pain may also be used. Certain anti-inflammatory medications, such as ibuprofen, may cause damage to the lining of the stomach and should be minimized or avoided in individuals with dyspepsia. If you are suffering from dyspepsia, talk to your doctor about the most current treatment options.

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Condition Specific Organizations

Following organizations serve the condition "Dyspepsia" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Dyspepsia" returned 675 free, full-text research articles on human participants. First 3 results:

Factors associated with health-related quality of life in patients with functional dyspepsia.
 

Author(s): Ibnu Fajariyadi Hantoro, Ari Fahrial Syam, Endang Mudjaddid, Siti Setiati, Murdani Abdullah

Journal:

 

Health-related quality of life (HRQoL) assessment is important for patients with functional dyspepsia. However, no studies have assessed factors associated with HRQoL reduction in such patients in an Asian population. This study aimed to determine the contribution of clinical, psychosocial, ...

Last Updated: 31 Dec 1969

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Measurement of Health-Related Quality of Life in Patients with Functional Dyspepsia.
 

Author(s): Ibnu Fajariyadi Hantoro, Ari Fahrial Syam

Journal: Acta Med Indones. 2018 Jan;50(1):88-92.

 

In up to 80% of dyspepsia patients who consult a physician in the hospital, dyspepsia is considered to be functional dyspepsia. Although not associated with increased mortality, functional dyspepsia is a burden at both the community and national levels because it can cause physical, ...

Last Updated: 31 Dec 1969

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Analyzing Determinant Factors for Pathophysiology of Functional Dyspepsia Based on Plasma Cortisol Levels, IL-6 and IL-8 Expressions and H. pylori Activity.
 

Author(s): Arina Widya Murni, Eryati Darwin, Nasrul Zubir, Adnil Edwin Nurdin

Journal: Acta Med Indones. 2018 Jan;50(1):38-45.

 

there are many determinant factors that may play roles in pathophysiology of functional dyspepsia. One of them is psychological stress that can increase plasma cortisol levels, alter inflammation process and affect Helicobacter pylori activity. No study has been conducted to find ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Dyspepsia" returned 115 free, full-text review articles on human participants. First 3 results:

Relamorelin and other ghrelin receptor agonists - future options for gastroparesis, functional dyspepsia and proton pump inhibitors-resistant non-erosive reflux disease.
 

Author(s): H Zatorski, P Mosinska, M Storr, J Fichna

Journal: J. Physiol. Pharmacol.. 2017 Dec;68(6):797-805.

 

There is an unmet need for effective pharmacological therapies for the treatment of gastroparesis and other upper gastrointestinal (GI) motility disorders, which reduce patients' quality of life and are a burden to the healthcare system. Ghrelin is an endogenous growth hormone secretagogue ...

Last Updated: 31 Dec 1969

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Functional Dyspepsia and Irritable Bowel Syndrome: Beyond Rome IV.
 

Author(s): Vincenzo Stanghellini

Journal: Dig Dis. 2017 ;35 Suppl 1():14-17.

 

The correct diagnosis of functional gastrointestinal disorders (FGIDs) is quite a challenge. The overlaps between syndromes can complicate the interpretation of clinical data.

Last Updated: 31 Dec 1969

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Mechanism of Action of STW 5 in Functional Dyspepsia and IBS: The Origin of Multi-Target.
 

Author(s): Hans-Dieter Allescher, Heba Abdel-Aziz

Journal: Dig Dis. 2017 ;35 Suppl 1():18-24.

 

STW 5 is a complex herbal combination preparation composed of 9 different herbal extracts. As an herbal medicinal product, this preparation is indicated for treating functional dyspepsia (FD) and irritable bowel syndrome (IBS). Its efficacy and practical applicability was demonstrated ...

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

The Predictive Value of Alarm Symptoms in Patients With Dyspepsia Based on Roman IV
 

Status: Recruiting

Condition Summary: Dyspepsia

 

Last Updated: 13 Jun 2018

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Efficacy of Bromopride and Simethicone Versus Bromopride in Functional Dyspepsia
 

Status: Recruiting

Condition Summary: Dyspepsia

 

Last Updated: 3 Jan 2018

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Effectiveness of tDCS for the Treatment of Functional Dyspepsia
 

Status: Recruiting

Condition Summary: Dyspepsia

 

Last Updated: 17 May 2016

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