Extended Spectrum Beta-Lactamase

Common Name(s)

Extended Spectrum Beta-Lactamase, ESBL, Escherichia coli and other Gram-negative antibiotic resistant bacteria

ESBL (Extended Spectrum Beta-Lactamase) are certain kinds of germs (bacteria) which make the enzyme beta-lactamase. Beta-lactamase can break down several types of antibiotics (medications that fight infection). So, when a person gets sick because of ESBL, the infection is harder to treat and may require different antibiotics. Infections due to ESBL usually affect the urinary tract and gut (intestine). They can also infect wounds and the blood. ESBL is mainly spread among people in hospitals and long-term care facilities. The elderly, individuals with a weakened immune system, and individuals having long term or frequent antibiotic treatment are also at an increased risk. Sometimes a person can carry ESBL and not be sick. This is called being colonized with ESBL. This person can spread ESBL to others. But because the person is not sick, no treatment is needed. ESBL infections, on the other hand, can be fatal if not treated properly.

ESBL can enter your body through the mouth, urinary tract or a wound. It can be passed directly from an infected or colonized person or indirectly through objects or unwashed hands. ESBL causes different symptoms depending on the location of the infection but may include a fever, pain and burning when urinating, diarrhea (may be bloody), stomach pains and cramps. Infections of skin wounds may cause redness around the wound and oozing of fluid. Infections in the blood may cause a high fever, chills, nausea and vomiting, shortness of breath and confusion.

The best prevention includes good hand washing or using alcohol based hand cleaners. Cuts and wounds should be kept clean and covered until healed. Diagnosis of an ESBL infection is made with a special lab test or culture using a sample of urine, stool, infected tissue, or blood. If you have been diagnosed with ESBL, talk with your doctor or specialist about the most current recommended treatment.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Extended Spectrum Beta-Lactamase" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Extended Spectrum Beta-Lactamase" returned 769 free, full-text research articles on human participants. First 3 results:

Extended-spectrum β-lactamase-producing E. coli septicemia among rectal carriers in the ICU.
 

Author(s): Minxue Liu, Mengjiao Li, Lijuan Wu, Qifei Song, Dan Zhao, Zhixing Chen, Mei Kang, Yi Xie

Journal: Medicine (Baltimore). 2018 Sep;97(38):e12445.

 

The aim of this study was to identify risk factors for extended-spectrum β-lactamase (ESBL)-producing Escherichia coli (E coli) bloodstream infection (BSI) among carriers hospitalized between March 2011 and June 2016 at the ICU of the West China Hospital.The cases were patients with ...

Last Updated: 31 Dec 1969

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Prevalence and antimicrobial susceptibility patterns of extended spectrum beta-lactamase producing Entrobacteriaceae in the University of Gondar Referral Hospital environments, northwest Ethiopia.
 

Author(s): Tigist Engda, Feleke Moges, Aschalew Gelaw, Setegn Eshete, Feleke Mekonnen

Journal:

 

This study aimed at assessing the magnitude, distribution, and the antimicrobial susceptibility of the extended spectrum beta-lactamase producing Entrobacteriaceae in the University of Gondar Referral Hospital environments.

Last Updated: 31 Dec 1969

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Extended-spectrum β-lactamase & carbapenemase-producing Gram-negative bacilli in neonates from a tertiary care centre in Dibrugarh, Assam, India.
 

Author(s): Utpala Devi, Reeta Bora, Jayanta Kumar Das, Jagadish Mahanta

Journal: Indian J. Med. Res.. 2018 01;147(1):110-114.

 

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Extended Spectrum Beta-Lactamase" returned 21 free, full-text review articles on human participants. First 3 results:

The Use of Noncarbapenem β-Lactams for the Treatment of Extended-Spectrum β-Lactamase Infections.
 

Author(s): Pranita D Tamma, Jesus Rodriguez-Bano

Journal: Clin. Infect. Dis.. 2017 Apr;64(7):972-980.

 

The continued rise in infections caused by extended-spectrum β-lactamase (ESBL)-producing pathogens is recognized globally as one of the most pressing concerns facing the healthcare community. Carbapenems are widely regarded as the antibiotics of choice for the treatment of ESBL-producing ...

Last Updated: 31 Dec 1969

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Clinical and Molecular Epidemiology of Extended-Spectrum Beta-Lactamase-Producing Klebsiella spp.: A Systematic Review and Meta-Analyses.
 

Author(s): Tirza C Hendrik, Anne F Voor In 't Holt, Margreet C Vos

Journal:

 

Healthcare-related infections caused by extended-spectrum beta-lactamase (ESBL)-producing Klebsiella spp. are of major concern. To control transmission, deep understanding of the transmission mechanisms is needed. This systematic review aimed to identify risk factors and sources, ...

Last Updated: 31 Dec 1969

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Extended-spectrum β-lactamase-producing Enterobacteriaceae in children: old foe, emerging threat.
 

Author(s): Paul J Lukac, Robert A Bonomo, Latania K Logan

Journal: Clin. Infect. Dis.. 2015 May;60(9):1389-97.

 

Extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae present an ever-growing burden in the hospital and community settings, across all ages and demographics. Infections due to ESBL-containing pathogens continue to be associated with significant morbidity and mortality ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 4 Sep 2017

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Urinary Tract Infection Due to Beta-lactamase-producing Enterobacteriaceae in Children
 

Status: Recruiting

Condition Summary: Urinary Tract Infections

 

Last Updated: 28 Jul 2017

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Prevalence of ESBL and CPE in French Nursing Homes
 

Status: Not yet recruiting

Condition Summary: Enterobacteriaceae Infections

 

Last Updated: 15 Jan 2018

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