Ebola Virus Disease

Common Name(s)

Ebola Virus Disease

Ebola virus disease (EVD), formerly known as Ebola haemorrhagic fever, is an extremely serious and deadly disease that has historically spread through remote areas of Central and West Africa. The Ebola virus spreads first by animal-to-human, then by human-to-human contact through blood, secretions, organs, or other bodily fluids. The Ebola virus however cannot be spread through the air such as by a cough or sneeze. This means it is not as highly contagious as many other viruses. Ebola is considered highly infectious, which means if you become infected with the virus, you are likely to become very sick. Symptoms of Ebola virus include sudden onset of a high fever, weakness, vomiting, diarrhea, headaches, rash, and impaired kidney and liver functions. As the disease progresses, internal bleeding occurs as does bleeding from the eyes. Patients often experience dehydration, which is treated with fluids containing high amounts of electrolytes. Although there is currently no approved vaccine or treatment for EVD, there are several promising treatments and a possible vaccine under development. At present, early medical support to lessen the effect of the symptoms is the best way to reduce chance of death. Standard infectious disease isolation protocols can help stop the spread of EVD.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ebola Virus Disease" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Ebola Virus Disease" returned 319 free, full-text research articles on human participants. First 3 results:

Establishing Ebola Virus Disease (EVD) diagnostics using GeneXpert technology at a mobile laboratory in Liberia: Impact on outbreak response, case management and laboratory systems strengthening.
 

Author(s): Philomena Raftery, Orla Condell, Christine Wasunna, Jonathan Kpaka, Ruth Zwizwai, Mahmood Nuha, Mosoka Fallah, Maxwell Freeman, Victoria Harris, Mark Miller, April Baller, Moses Massaquoi, Victoria Katawera, John Saindon, Philip Bemah, Esther Hamblion, Evelyn Castle, Desmond Williams, Alex Gasasira, Tolbert Nyenswah

Journal:

 

The 2014-16 Ebola Virus Disease (EVD) outbreak in West Africa highlighted the necessity for readily available, accurate and rapid diagnostics. The magnitude of the outbreak and the re-emergence of clusters of EVD cases following the declaration of interrupted transmission in Liberia, ...

Last Updated: 31 Dec 1969

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Emergence of Vaccine-Derived Polioviruses during Ebola Virus Disease Outbreak, Guinea, 2014-2015.
 

Author(s): Maria Dolores Fernandez-Garcia, Manasi Majumdar, Ousmane Kebe, Aichatou D Fall, Moussa Kone, Mouctar Kande, Moustapha Dabo, Mohamed Salif Sylla, Djenou Sompare, Wayne Howard, Ousmane Faye, Javier Martin, Kader Ndiaye

Journal: Emerging Infect. Dis.. 2018 01;24(1):65-74.

 

During the 2014-2015 outbreak of Ebola virus disease in Guinea, 13 type 2 circulating vaccine-derived polioviruses (cVDPVs) were isolated from 6 polio patients and 7 healthy contacts. To clarify the genetic properties of cVDPVs and their emergence, we combined epidemiologic and virologic ...

Last Updated: 31 Dec 1969

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Potential for broad-scale transmission of Ebola virus disease during the West Africa crisis: lessons for the Global Health security agenda.
 

Author(s): Eduardo A Undurraga, Cristina Carias, Martin I Meltzer, Emily B Kahn

Journal:

 

The 2014-2016 Ebola crisis in West Africa had approximately eight times as many reported deaths as the sum of all previous Ebola outbreaks. The outbreak magnitude and occurrence of multiple Ebola cases in at least seven countries beyond Liberia, Sierra Leone, and Guinea, hinted at ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Ebola Virus Disease" returned 55 free, full-text review articles on human participants. First 3 results:

A Systematic Review of Computational Drug Discovery, Development, and Repurposing for Ebola Virus Disease Treatment.
 

Author(s): James Schuler, Matthew L Hudson, Diane Schwartz, Ram Samudrala

Journal:

 

Ebola virus disease (EVD) is a deadly global public health threat, with no currently approved treatments. Traditional drug discovery and development is too expensive and inefficient to react quickly to the threat. We review published research studies that utilize computational approaches ...

Last Updated: 31 Dec 1969

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An update on ocular complications of Ebola virus disease.
 

Author(s): Jessica G Shantha, Ian Crozier, Steven Yeh

Journal: Curr Opin Ophthalmol. 2017 Nov;28(6):600-606.

 

This review provides a summary of our current understanding of the ophthalmic manifestations of Ebola virus disease (EVD), pathogenesis, treatment options and directions for future study. The individual, public health and global health implications of eye disease in EVD survivors are discussed.

Last Updated: 31 Dec 1969

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Neuropsychological long-term sequelae of Ebola virus disease survivors - A systematic review.
 

Author(s): Felix Lötsch, Jenny Schnyder, Abraham Goorhuis, Martin P Grobusch

Journal: Travel Med Infect Dis. ;18():18-23.

 

The recent West African Ebola virus disease (EVD) outbreak had catastrophic impact on populations, health care systems and economies of the affected countries. Somatic symptoms have been reported to persist long beyond the acute infection. This review was conducted to provide an overview ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

R3470-3471-3479 Expanded Access Protocol (EAP) for Treatment of Ebola
 

Status: Available

Condition Summary: Ebola Virus Disease

 

Last Updated: 22 Jun 2018

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Partnership for Research on Ebola VACcinations
 

Status: Recruiting

Condition Summary: Ebola Virus Disease

 

Last Updated: 30 Jul 2018

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