Ebola Virus Disease

Common Name(s)

Ebola Virus Disease

Ebola virus disease (EVD), formerly known as Ebola haemorrhagic fever, is an extremely serious and deadly disease that has historically spread through remote areas of Central and West Africa. The Ebola virus spreads first by animal-to-human, then by human-to-human contact through blood, secretions, organs, or other bodily fluids. The Ebola virus however cannot be spread through the air such as by a cough or sneeze. This means it is not as highly contagious as many other viruses. Ebola is considered highly infectious, which means if you become infected with the virus, you are likely to become very sick. Symptoms of Ebola virus include sudden onset of a high fever, weakness, vomiting, diarrhea, headaches, rash, and impaired kidney and liver functions. As the disease progresses, internal bleeding occurs as does bleeding from the eyes. Patients often experience dehydration, which is treated with fluids containing high amounts of electrolytes. Although there is currently no approved vaccine or treatment for EVD, there are several promising treatments and a possible vaccine under development. At present, early medical support to lessen the effect of the symptoms is the best way to reduce chance of death. Standard infectious disease isolation protocols can help stop the spread of EVD.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ebola Virus Disease" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Ebola Virus Disease" returned 207 free, full-text research articles on human participants. First 3 results:

The post-Ebola virus disease scourge in Nigeria: Individual levels of preparedness among physicians in the Federal Capital Territory Abuja.
 

Author(s): Adewale L Alli, Maxwell M Nwegbu, Perpetua U Ibekwe, Titus S Ibekwe

Journal: Ann Afr Med. ;15(4):171-178.

 

Ebola virus disease (EVD) is a viral hemorrhagic illness with great propensity for spread across international borders. The latest outbreak in the West African region, which involved Nigeria, was the worst among previously documented 25 outbreaks since discovery in 1976. The Nigerian ...

Last Updated: 17 Nov 2016

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Clinical presentations and outcomes of patients with Ebola virus disease in Freetown, Sierra Leone.
 

Author(s): Ying-Jie Ji, Xue-Zhang Duan, Xu-Dong Gao, Lei Li, Chen Li, Dong Ji, Wen-Gang Li, Li-Fu Wang, Yu-Hua Meng, Xiao Yang, Bin-Fang Ling, Xue-Ai Song, Mei-Lei Gu, Tao Jiang, She-Ku M Koroma, James Bangalie, Hui-Juan Duan

Journal:

 

Clinical and laboratory data were collected and analysed from patients with Ebola virus disease (EVD) in Jui Government Hospital in Freetown, Sierra Leone, where patients with EVD were received and/or treated from October 1, 2014 to March 21, 2015 during the West Africa EVD outbreak.

Last Updated: 3 Nov 2016

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Clinical profile and containment of the Ebola virus disease outbreak in two large West African cities, Nigeria, July-September 2014.
 

Author(s): Chima Ohuabunwo, Celestine Ameh, Oyin Oduyebo, Anthony Ahumibe, Bamidele Mutiu, Adebola Olayinka, Wasiu Gbadamosi, Erika Garcia, Carolina Nanclares, Wale Famiyesin, Abdulaziz Mohammed, Patrick Nguku, Richard I Koko, Joshua Obasanya, Durojaye Adebayo, Yemi Gbadegesin, Oni Idigbe, Olukayode Oguntimehin, Sara Nyanti, Charles Nzuki, Ismail Abdus-Salam, Joseph Adeyemi, Nnanna Onyekwere, Emmanuel Musa, David Brett-Major, Faisal Shuaib, Abdulsalami Nasidi

Journal: Int. J. Infect. Dis.. 2016 Dec;53():23-29.

 

The Ebola virus disease (EVD) outbreak in Nigeria began when an infected diplomat from Liberia arrived in Lagos, the most populous city in Africa, with subsequent transmission to another large city.

Last Updated: 6 Sep 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Ebola Virus Disease" returned 31 free, full-text review articles on human participants. First 3 results:

BCX4430 - A broad-spectrum antiviral adenosine nucleoside analog under development for the treatment of Ebola virus disease.
 

Author(s): Raymond Taylor, Pravin Kotian, Travis Warren, Rekha Panchal, Sina Bavari, Justin Julander, Sylvia Dobo, Angela Rose, Yahya El-Kattan, Brian Taubenheim, Yarlagadda Babu, William P Sheridan

Journal: J Infect Public Health. ;9(3):220-6.

 

The adenosine nucleoside analog BCX4430 is a direct-acting antiviral drug under investigation for the treatment of serious and life-threatening infections from highly pathogenic viruses, such as the Ebola virus. Cellular kinases phosphorylate BCX4430 to a triphosphate that mimics ...

Last Updated: 21 May 2016

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[Current status of drug treatment against the disease caused by the Ebola virus].
 

Author(s): Jordi Reina

Journal: Rev Esp Quimioter. 2016 Feb;29(1):1-7.

 

The recent epidemic of disease caused by the Ebola virus has highlighted the need to develop specific drugs and have to deal with this entity. According to virological analysis they have been designed to give you some new drugs and are proven to others might be effective against this ...

Last Updated: 18 Feb 2016

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Recurrence and reinfection--a new paradigm for the management of Ebola virus disease.
 

Author(s): C Raina MacIntyre, Abrar Ahmad Chughtai

Journal: Int. J. Infect. Dis.. 2016 Feb;43():58-61.

 

Ebola virus disease (EVD) is an understudied infection and many aspects of viral transmission and clinical course remain unclear. With over 17000 EVD survivors in West Africa, the World Health Organization has focused its strategy on managing survivors and the risk of re-emergence ...

Last Updated: 13 Feb 2016

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Multiple Treatments for Ebola Virus Disease (EVD)
 

Status: Not yet recruiting

Condition Summary: Ebola Virus Disease

 

Last Updated: 1 Mar 2015

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Ebola Virus Disease Survivors: Clinical and Immunologic Follow-up
 

Status: Recruiting

Condition Summary: Ebola Virus Disease

 

Last Updated: 24 Jan 2017

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Partnership for Research on Ebola VACcinations
 

Status: Not yet recruiting

Condition Summary: Ebola Virus Disease

 

Last Updated: 9 Nov 2016

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