Ehlers-Danlos syndrome classic type

Common Name(s)

Ehlers-Danlos syndrome classic type, Ehlers-Danlos syndrome, type 1, Ehlers-Danlos syndrome, type 2

Ehlers-Danlos syndrome (EDS) is a rare tissue disorder that has six specific types. EDS affects a person’s connective tissue, which separates, connects and supports different organs in the body. People with EDS usually cannot make enough normal collagen, a connective tissue protein.

Ehlers-Danlos syndrome classic type (formerly EDS type I and II) noticeably affects the skin. The skin is usually smooth, velvety, abnormally stretchy (hyperelastic), and very fragile; it tends to tear with minor trauma, especially over pressure points (knees, elbows). Wounds may heal slowly and split open with little bleeding, leaving thin and wide “cigarette paper” scars (atrophic scars). Babies may appear “floppy” due to low muscle tone (hypotonia), and may take longer to develop motor skills. About half of those with classical type EDS have mitral valve prolapse, which affects blood flow between the chambers of the heart. Less common but severe complications include spontaneous ruptures of large arteries.

Other symptoms, similar to hypermobility type, may include easy bruising, joints that dislocate easily, joint pain, fatigue, and muscle cramping. There is no cure for classical type EDS; it is a life-long condition that requires close monitoring. Management includes physiotherapy, padding, lifestyle changes, plus yearly echocardiograms for people with related heart complications.

Classical type EDS is usually passed through families in an autosomal dominant manner, meaning only one copy of the changed or mutated gene is needed to have the condition. About 50% of people with the condition are the first in their families to have the genetic mutation. If you or your child has been diagnosed with classical type EDS, talk to your doctor about the most current treatment options. A genetic counselor can be helpful to discuss inheritance and risks to other family members. Support groups are also available for more resources and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ehlers-Danlos syndrome classic type" for support, advocacy or research.

Ehlers-Danlos Support UK

EDS UK was set up in 1987 to support, advise and inform those living with Ehlers-Danlos Syndrome. We aim to help them live a full, active and positive life. Over 25 years later, we remain the only UK based charity that exclusively represents and supports people with all types of EDS. We run regular events and conferences to bring our community together, and produce literature and merchandise to increase understanding and improve management of the condition. We have over 30 support groups around the country to provide our members with a local peer support network and we hope to expand this

Last Updated: 17 Aug 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Ehlers-Danlos syndrome classic type" for support, advocacy or research.

Ehlers-Danlos Support UK

EDS UK was set up in 1987 to support, advise and inform those living with Ehlers-Danlos Syndrome. We aim to help them live a full, active and positive life. Over 25 years later, we remain the only UK based charity that exclusively represents and supports people with all types of EDS. We run regular events and conferences to bring our community together, and produce literature and merchandise to increase understanding and improve management of the condition. We have over 30 support groups around the country to provide our members with a local peer support network and we hope to expand this

http://www.ehlers-danlos.org

Last Updated: 17 Aug 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Ehlers-Danlos syndrome classic type" returned 2 free, full-text research articles on human participants. First 3 results:

Dental problems in a patient with the classic type of Ehlers-Danlos syndrome--a case report.
 

Author(s): Piotr Osica, Anna Janas

Journal: Dev Period Med. ;19(4):496-502.

 

The huge progress in diagnostic and therapeutic procedures in developmental medicine allowed not only to save lives of many children and adolescents, but also enforced the necessity of close cooperation between many specialists. Unfortunately dental treatment is still not an integral ...

Last Updated: 17 Mar 2016

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Severe conjunctivochalasis in association with classic type Ehlers-Danlos syndrome.
 

Author(s): John K Whitaker, Philip Alexander, David Y S Chau, Naing L Tint

Journal:

 

Inferior conjunctivochalasis is common, but is rarely severe enough to require conjunctival excision. This report describes a patient with severe conjunctivochalasis who was subsequently diagnosed with Ehlers Danlos Syndrome, Classic Type.

Last Updated: 23 Nov 2012

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Ehlers-Danlos syndrome classic type" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.