Endocarditis

Common Name(s)

Endocarditis

Endocarditis is condition affecting the heart lining, heart valves, or blood vessels. Endocarditis can be caused by bacterial or fungal infection (infective endocarditis) or by blood clots that form on the heart valves or lining (non-infective endocarditis or non-bacterial thrombotic endocarditis (NBTE)). In cases of infective endocarditis, the infected area becomes inflamed and immune cells can be seen in the affected area. In cases of non-infective endocarditis, there is no inflammation of the heart lining or valves.

The young and the old are at increased risk of experiencing endocarditis. Those with cancer, diabetes, HIV/AIDS, or a weakened immune system are also at an increased risk. Those with certain blood clotting conditions are at increased risk for NBTE. Symptoms of infective endocarditis can include fever, chills, fatigue, and achiness. Symptoms of both infective and non-infective endocarditis can include coughing, shortness of breath, weight loss, muscle and joint pain, a heart murmur, and small spots of blood under the skin or fingernails. It is important to seek treatment if you experience these symptoms. If untreated, endocarditis can be fatal.

Endocarditis can often be diagnosed using a physical examination, an ultrasound of the heart (echocardiogram), testing of heart rhythm with an EKG, blood cultures to test for bacteria, and an X-ray of the chest. Treatment for infective endocarditis includes antibiotics. Treatment for NBTE usually includes anticoagulants to decrease the likelihood of blood clots and to help break up any existing clots. If you or a loved one has been diagnosed with endocarditis, talk to your doctor about the most current treatment options.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Endocarditis" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Endocarditis" returned 2748 free, full-text research articles on human participants. First 3 results:

Viridans streptococcal infective endocarditis associated with fixed orthodontic appliance managed surgically by mitral valve plasty: A case report.
 

Author(s): Victoria Birlutiu, Rares Mircea Birlutiu, Victor Sebastian Costache

Journal: Medicine (Baltimore). 2018 Jul;97(27):e11260.

 

Streptococcus viridans, a heterogeneous group of alpha-hemolytic streptococci, is part of the normal flora of the mouth, usually responsible for dental caries (Streptococcus mutans, Streptococcus sanguinis), and pericoronitis, as well as for subacute infective endocarditis. They are ...

Last Updated: 31 Dec 1969

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Early results for active infective endocarditis.
 

Author(s): Mahdi Aithoussa, Noureddine Atmani, Reda Mounir, Younes Moutakiallah, Mehdi Bamous, Abdessamad Abdou, Fouad Nya, Anis Seghrouchni, Siham Bellouize, Mohamed Drissi, Mostafa Elouennass, Youssef Elbekkali, Abdelatif Boulahya

Journal:

 

Cardiac surgery is frequently needed during active phase of infective endocarditis (IE). The purpose of this study was to analyze the immediate and late results and determine the risk factors for death.

Last Updated: 31 Dec 1969

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Combined Surgical and Medical Therapy for Candida Prosthetic Endocarditis in a Patient with Repaired Tetralogy of Fallot.
 

Author(s): Kana Kubota, Katsura Soma, Masae Uehara, Toshiro Inaba, Akihito Saito, Norihiko Takeda, Masaru Hatano, Hiroyuki Morita, Ryo Inuzuka, Yasutaka Hirata, Atsushi Yao, Issei Komuro

Journal: Int Heart J. 2018 Jul;59(4):877-880.

 

Candida prosthetic endocarditis (CPE) is an uncommon and fatal complication in adults with congenital heart disease. The current guidelines for the management of fungal endocarditis recommend a combination of surgical and medical therapy. However, it still remains uncertain when surgical ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Endocarditis" returned 281 free, full-text review articles on human participants. First 3 results:

The diagnosis of microorganism involved in infective endocarditis (IE) by polymerase chain reaction (PCR) and real-time PCR: A systematic review.
 

Author(s): Reza Faraji, Mostafa Behjati-Ardakani, Seyed Mohammad Moshtaghioun, Seyed Mehdi Kalantar, Seyedeh Mahdieh Namayandeh, Mohammadhossien Soltani, Mahmood Emami, Hengameh Zandi, Ali Dehghani Firoozabadi, Mahmood Kazeminasab, Nastaran Ahmadi, Mohammadtaghi Sarebanhassanabadi

Journal: Kaohsiung J. Med. Sci.. 2018 Feb;34(2):71-78.

 

Broad-range bacterial rDNA polymerase chain reaction (PCR) followed by sequencing may be identified as the etiology of infective endocarditis (IE) from surgically removed valve tissue; therefore, we reviewed the value of molecular testing in identifying organisms' DNA in the studies ...

Last Updated: 31 Dec 1969

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Probiotics and infective endocarditis in patients with hereditary hemorrhagic telangiectasia: a clinical case and a review of the literature.
 

Author(s): Evangelo Boumis, Alessandro Capone, Vincenzo Galati, Carolina Venditti, Nicola Petrosillo

Journal:

 

In the last decades, probiotics have been widely used as food supplements because of their putative beneficial health effects. They are generally considered safe but rare reports of serious infections caused by bacteria included in the definition of probiotics raise concerns on their ...

Last Updated: 31 Dec 1969

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Successful management of a complicated clinical crisis: A patient with left-sided endocarditis and secondary hemophagocytic lymphohistiocytosis: a rare case report and literature review.
 

Author(s): Peipei Xu, Hui Zeng, Min Zhou, Jian Ouyang, Bing Chen, Qiguo Zhang

Journal: Medicine (Baltimore). 2017 Dec;96(51):e9451.

 

Hemophagocytic lymphohistiocytosis (HLH) secondary to methicillin-resistant Staphylococcus epidermidis (MRSE)-related left-sided infectious endocarditis had never been reported before. In the last decade, daptomycin, a novel lipopeptide antibiotic, showed its excellent role in anti-Gram-positive ...

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Management of Infectious Endocarditis as Part of a Multidisciplinary Consensus Meeting
 

Status: Recruiting

Condition Summary: Endocarditis

 

Last Updated: 9 Feb 2018

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Last Updated: 13 Mar 2018

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Last Updated: 25 Jan 2018

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