Exogenous ochronosis

Common Name(s)

Exogenous ochronosis

Exogenous ochronosis refers to the bluish-black discoloration of certain tissues, such as the ear cartilage, the ocular (eye) tissue, and other body locations when it is due to exposure to various substances.  It has been reported most commonly with topical application of hydroquinones to the skin. The discoloration may be caused by an effect on tyrosinase (an enzyme located in melanocytes, which are skin cells that produce pigment), or by inhibiting homogentisic acid oxidase, resulting in the accumulation and deposition of homogentisic acid (HGA) in cartilage. The discoloration is often permanent, but when exogenous ochronosis is caused by topical hydroquinones, carbon dioxide lasers and dermabrasion have been reported to be helpful. Exogenous ochronosis is different from hereditary ochronosis, which is an inherited condition that occurs with alkaptonuria.
 

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Condition Specific Organizations

Following organizations serve the condition "Exogenous ochronosis" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Exogenous ochronosis" returned 6 free, full-text research articles on human participants. First 3 results:

Exogenous ochronosis.
 

Author(s): Avninder Singh, V Ramesh

Journal: Indian J. Med. Res.. 2014 Feb;139(2):327.

 

Last Updated: 31 Dec 1969

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Exogenous ochronosis in a Chinese patient: use of dermoscopy aids early diagnosis and selection of biopsy site.
 

Author(s): Wen Chun Liu, Hong Liang Tey, Joyce Siong See Lee, Boon Kee Goh

Journal: Singapore Med J. 2014 Jan;55(1):e1-3.

 

The diagnosis of exogenous ochronosis is often challenging and requires a high index of suspicion. Herein, we report a case of exogenous ochronosis in a Chinese patient. The condition was caused by the use of bleaching agents, including creams containing hydroquinone. We demonstrate ...

Last Updated: 31 Dec 1969

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Dermoscopic criteria for differentiating exogenous ochronosis from melasma.
 

Author(s): Niti Khunger, Rajat Kandhari

Journal: Indian J Dermatol Venereol Leprol. ;79(6):819-21.

 

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Exogenous ochronosis" returned 1 free, full-text review articles on human participants. First 3 results:

Exogenous ochronosis: case report and literature review.
 

Author(s): Viviane Maria Rocha Martins, Antônio Renê Diógenes de Sousa, Natália de Carvalho Portela, Celina Aguiar Frota Tigre, Lucidi Maria Saraiva Gonçalves, Rômulo José de Lucena Castro Filho

Journal: An Bras Dermatol. ;87(4):633-6.

 

Exogenous ochronosis is a rare, cosmetically disfiguring condition, resulting from the longterm use of topical hydroquinone in treatment of melasma. It manifests as gray-brown or blue-black macules in hydroquinone-exposed regions. The exact incidence of ochronosis is unknown. High ...

Last Updated: 31 Dec 1969

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