Exophthalmos

Common Name(s)

Exophthalmos

Exophthalmos is a condition in which the eye or eyes extend or bulge out of the eye socket, often giving the affected individual a startled appearance. Exophthalmos affects women more often than men, and is most common in individuals of European descent who are between the age of 40 and 70 years old. Exophthalmos may be caused by infection, inflammation, injury, tumors, vascular disorders, and other genetic disorders. Graves’ disease is an autoimmune disorder characterized by elevated levels of thyroid hormone in the blood and is one of the most common causes of exophthalmos.

Symptoms seen in the eyes of individuals affected by exophthalmos include irritation, dryness, excessive tearing, and increased sensitivity to light. Diagnosis is made with tests to measure the movement of the eyes, the size and structure of the eye socket, and thyroid hormone levels in Grave’s disease. If untreated, complications of exophthalmos include corneal damage, permanent protrusion of the eyes, and severe irritation of the eyes. In severe cases, blindness may result from damage to the optic nerve.

Treatment for exophthalmos depends on the cause of the condition. Medications may be used to correct thyroid hormone levels in exophthalmos caused by Graves’ disease. Corticosteroids or radiation therapy may be used to reduce swelling and inflammation of the eye. Severe cases of exophthalmos may require surgery. If you or your child has been diagnosed with exophthalmos, talk to your doctor about the most current treatment options.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Exophthalmos" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Exophthalmos" returned 114 free, full-text research articles on human participants. First 3 results:

[Pulsatile exophthalmos revealing spheno-orbital agenesis associated with Von Recklinghausen's disease].
 

Author(s): Imane Ait Belaid, Safouane Khairallah, Soumaya Alj, Mariem Ouali Idrissi, Najat Cherif Idrissi El Ganouni

Journal:

 

Ophthalmological manifestations of Von Recklinghausen disease are rare. Only a few cases have been reported in the international literature. We here report the case of a patient with pulsatile exophthalmos revealing spheno-orbital agenesis associated with Von Recklinghausen's disease.

Last Updated: 31 Dec 1969

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Acute Myeloid Leukemia with Initial Presentation of Facial Palsy and Exophthalmos.
 

Author(s): Chi-Wei Young, Che-Sheng Ho, Nan-Chang Chiu, Hsi-Che Liu, Der-Cherng Liang

Journal: Acta Neurol Taiwan. 2016 Mar;25(1):18-20.

 

Last Updated: 31 Dec 1969

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The First Reported Case of Erdheim-Chester Disease in Egypt with Bilateral Exophthalmos, Loss of Vision, and Multi-Organ Involvement in a Young Woman.
 

Author(s): Emad E Abdellateef, Ayman R Abdelhai, Heba H Gawish, Ghada A Abdulmonaem, Eman H Abdelbary, Ahmed I Ahmed

Journal:

 

Erdheim-Chester disease is a rare non-Langerhans-cell histiocytosis of unknown etiology with multi-organ involvement.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Exophthalmos" returned 5 free, full-text review articles on human participants. First 3 results:

Arachnoid cyst in the middle cranial fossa presenting with pulsatile exophthalmos: case report and literature review.
 

Author(s): Atsushi Saito, Hiroyuki Kon, Shinya Haryu, Masaki Mino, Tatsuya Sasaki, Michiharu Nishijima

Journal: Neurol. Med. Chir. (Tokyo). 2014 ;54(7):563-6.

 

A 20-year-old woman suffered gradual progression of right pulsatile exophthalmos and slight headache. Computed tomography (CT) demonstrated outward and downward displacement of the right globe and an arachnoid cyst in the right middle cranial fossa associated with thinned and anterior ...

Last Updated: 31 Dec 1969

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[How to investigate a patient with exophthalmos?].
 

Author(s): V Brun, F Lafitte, M Hamedani, F Héran, P Koskas, O Bergès, J Chiras, J D Piekarski

Journal: J Neuroradiol. 2002 Sep;29(3):161-72.

 

Exophthalmos is the main symptom revealing orbital masses. This sign needs to be imaged mainly by MRI and/or CT. As Graves disease is the main etiology of exophthalmos, CT scan should be performed as the initial imaging modality. Indications for US and Doppler are mostly limited to ...

Last Updated: 31 Dec 1969

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Polyarteritis nodosa (PN) complicated with unilateral exophthalmos.
 

Author(s): R Koike, M Yamada, T Matsunaga, S Yoshida, H Tsukagoshi

Journal: Intern. Med.. 1993 Mar;32(3):232-6.

 

A 58-year-old woman suddenly developed right exophthalmos. A CT scan of her orbit revealed an increase in volume and density of extraocular muscles and intraorbital soft tissues that resembled exophthalmos in Graves' disease. The exophthalmos gradually improved without treatment. ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 8 Dec 2017

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Last Updated: 7 Sep 2017

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Efficacy and Safety of Cholestyramine and Prednisolone as Adjunctive Therapy in Treatment of Overt Hyperthyroidism
 

Status: Recruiting

Condition Summary: Hyperthyroidism; Graves Disease

 

Last Updated: 1 Oct 2017

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