Familial Hemiplegic Migraine

Common Name(s)

Familial Hemiplegic Migraine

Description for this condition is not yet available.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Familial Hemiplegic Migraine" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Familial Hemiplegic Migraine" returned 56 free, full-text research articles on human participants. First 3 results:

Early-onset familial hemiplegic migraine due to a novel SCN1A mutation.
 

Author(s): Chunxiang Fan, Stefan Wolking, Frank Lehmann-Horn, Ulrike Bs Hedrich, Tobias Freilinger, Holger Lerche, Guntram Borck, Christian Kubisch, Karin Jurkat-Rott

Journal: Cephalalgia. 2016 Nov;36(13):1238-1247.

 

Introduction Familial hemiplegic migraine (FHM) is a rare autosomal dominant subtype of migraine with aura. The FHM3 subtype is caused by mutations in SCN1A, which is also the most frequent epilepsy gene encoding the voltage-gated Na+ channel NaV1.1. The aim of this study was to explore ...

Last Updated: 31 Dec 1969

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Repeated encephalopathy and hemicerebral atrophy in a patient with familial hemiplegic migraine type 1.
 

Author(s): Yuichi Tashiro, Tsuneo Yamazaki, Shun Nagamine, Yuji Mizuno, Adachi Yoshiki, Koichi Okamoto

Journal: Intern. Med.. 2014 ;53(19):2245-50.

 

We herein describe a case of a 38-year-old man with familial hemiplegic migraine with a T666M mutation in the electrical potential-dependent calcium ion channel (CACNA1A) gene. His migraine was accompanied by hemiparesis and impaired consciousness. Brain magnetic resonance imaging ...

Last Updated: 31 Dec 1969

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Synaptic gain-of-function effects of mutant Cav2.1 channels in a mouse model of familial hemiplegic migraine are due to increased basal [Ca2+]i.
 

Author(s): Mariano N Di Guilmi, Tiantian Wang, Carlota Gonzalez Inchauspe, Ian D Forsythe, Michel D Ferrari, Arn M J M van den Maagdenberg, J Gerard G Borst, Osvaldo D Uchitel

Journal: J. Neurosci.. 2014 May;34(21):7047-58.

 

Specific missense mutations in the CACNA1A gene, which encodes a subunit of voltage-gated CaV2.1 channels, are associated with familial hemiplegic migraine type 1 (FHM1), a rare monogenic subtype of common migraine with aura. We used transgenic knock-in (KI) mice harboring the human ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Familial Hemiplegic Migraine" returned 2 free, full-text review articles on human participants. First 3 results:

Genetic effects of ATP1A2 in familial hemiplegic migraine type II and animal models.
 

Author(s): Stephanie M Gritz, Richard A Radcliffe

Journal:

 

Na(+)/K(+)-ATPase alpha 2 (Atp1a2) is an integral plasma membrane protein belonging to the P-type ATPase family that is responsible for maintaining the sodium (Na(+)) and potassium (K(+)) gradients across cellular membranes with hydrolysis of ATP. Atp1a2 contains two subunits, alpha ...

Last Updated: 31 Dec 1969

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Insights into migraine mechanisms and CaV2.1 calcium channel function from mouse models of familial hemiplegic migraine.
 

Author(s): Daniela Pietrobon

Journal: J. Physiol. (Lond.). 2010 Jun;588(Pt 11):1871-8.

 

Migraine is a very common disabling brain disorder with unclear pathogenesis. A subtype of migraine with aura (familial hemiplegic migraine type 1: FHM1) is caused by mutations in CaV2.1 (P/Q-type) Ca2+ channels. This review describes the functional consequences of FHM1 mutations ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.