Familial psoriasis

Common Name(s)

Familial psoriasis, PSORS2

Familial psoriasis (PSORS2), is a specific form of psoriasis that is caused by a change (mutation) in the CARD14 gene and usually affects more than one person in a family. Psoriasis is a long-lasting (chronic) skin condition that causes cells to grow too quickly, resulting in red, scaly, itchy patches on the skin. In normal skin, cells flake off from the surface and are replaced by new cells every four weeks. In people with psoriasis, new cells form and quickly move to the surface of the skin, forming thick patches (plaques) that typically appear on the elbows, knees, scalp, lower back, hands, or feet. These patches are usually dry and itchy. In some cases, the areas where bones meet (joints) may also become swollen and stiff, which is called psoriatic arthritis.

Psoriasis is thought to be an autoimmune disease, which is a disorder that causes the body’s immune system to attack its own cells and tissues. Both environmental and genetic factors likely play a role in all forms of psoriasis. However, it is thought that genetic mutations play a stronger role in familial forms of psoriasis. Mutations in the CARD14 gene have been found to be the cause for most cases of PSORS2. This gene provides instructions for the body to make a protein that helps control the body’s immune system. Having a mutation in this gene can lead to overreaction of the immune system, which is the cause of the psoriasis in PSORS2.

Psoriasis is usually diagnosed when a doctor examines the skin. The doctor may also remove and examine a small piece of the affected skin (skin biopsy). There is no cure for psoriasis but there are many treatment options that may help control the symptoms. These include creams that can be applied to the surface of the skin (topical), oral medications, moisturizers, and light therapy. If you have been diagnosed with psoriasis, talk with your doctor about all treatment options. Support groups can provide more information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Familial psoriasis" for support, advocacy or research.

National Psoriasis Foundation

Our mission is to find a cure for psoriasis and psoriatic arthritis and to eliminate their devastating effects through research, advocacy and education.

Last Updated: 26 Jul 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Familial psoriasis" for support, advocacy or research.

National Psoriasis Foundation

Our mission is to find a cure for psoriasis and psoriatic arthritis and to eliminate their devastating effects through research, advocacy and education.

http://www.psoriasis.org/

Last Updated: 26 Jul 2015

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Familial psoriasis" returned 15 free, full-text research articles on human participants. First 3 results:

Increased psoriasis frequency in patients with familial Mediterranean fever.
 

Author(s): Abdulsamet Erden, Ezgi Deniz Batu, Emrah Seyhoğlu, Alper Sari, Hafize Emine Sönmez, Berkan Armagan, Selcan Demir, Emre Bilgin, Levent Kilic, Omer Karadag, Ali Akdogan, Yelda Bilginer, Ihsan Ertenli, Sedat Kiraz, Sule Apras Bilgen, Umut Kalyoncu

Journal: Ups. J. Med. Sci.. 2018 Mar;123(1):57-61.

 

Familial Mediterranean fever (FMF) is a periodic fever syndrome caused by MEFV mutations. FMF may be associated with psoriasis in some cases. The prevalence of psoriasis in the normal Turkish population is 0.42%. We aimed to investigate the prevalence of psoriasis among FMF patients ...

Last Updated: 31 Dec 1969

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Intra-familial Variation in Clinical Phenotype of CARD14-related Psoriasis.
 

Author(s): Marina Eskin-Schwartz, Lina Basel-Vanagaite, Michael David, Irina Lagovsky, Dan Ben-Amitai, Pola Smirin-Yosef, Lihi Atzmony, Emmilia Hodak

Journal: Acta Derm. Venereol.. 2016 Nov;96(7):885-887.

 

Psoriasis is a multifactorial chronic inflammatory disease. Monogenic psoriasis has been described recently, including dominantly inherited plaque and generalized pustular types, related to activating mutations in the CARD14 gene. We describe here a family with CARD14-related psoriasis, ...

Last Updated: 31 Dec 1969

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Activating CARD14 Mutations Are Associated with Generalized Pustular Psoriasis but Rarely Account for Familial Recurrence in Psoriasis Vulgaris.
 

Author(s): Dorottya M Berki, Lu Liu, Siew-Eng Choon, A David Burden, Christopher E M Griffiths, Alexander A Navarini, Eugene S Tan, Alan D Irvine, Annamari Ranki, Takeshi Ogo, Gabriela Petrof, Satveer K Mahil, Michael Duckworth, Michael H Allen, Pasquale Vito, Richard C Trembath, John McGrath, Catherine H Smith, Francesca Capon, Jonathan N Barker

Journal: J. Invest. Dermatol.. 2015 Dec;135(12):2964-2970.

 

Caspase recruitment family member 14 (CARD14, also known as CARMA2), is a scaffold protein that mediates NF-κB signal transduction in skin keratinocytes. Gain-of-function CARD14 mutations have been documented in familial forms of psoriasis vulgaris (PV) and pityriasis rubra pilaris ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Familial psoriasis" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Observational Study of the Genetic Architecture of Neutrophil-Mediated Inflammatory Skin Diseases
 

Status: Recruiting

Condition Summary: Other Specified Inflammatory Disorders of Skin or Subcutaneous Tissue; Pyoderma Gangrenosum; Erosive Pustular Dermatosis of the Scalp; Sweet's Syndrome; Behcet's Disease; Bowel-associated Dermatosis-arthritis Syndrome; Pustular Psoriasis; Acute Generalized Exanthematous Pustulosis; Keratoderma Blenorrhagicum; Sneddon-Wilkinson Disease; IgA Pemphigus; Amicrobial Pustulosis of the Folds; Infantile Acropustulosis; Transient Neonatal Pustulosis; Neutrophilic Eccrine Hidradenitis; Rheumatoid Neutrophilic Dermatitis; Neutrophilic Urticaria; Still's Disease; Erythema Marginatum; Unclassified Periodic Fever Syndromes / Autoinflammatory Syndromes; Dermatitis Herpetiformis; Linear IgA Bullous Dermatosis; Bullous Systemic Lupus Erythematosus; Inflammatory Epidermolysis Bullosa Aquisita; Neutrophilic Dermatosis of the Dorsal Hands (Pustular Vasculitis); Small Vessel Vasculitis Including Urticarial Vasculitis; Erythema Elevatum Diutinum; Medium Vessel Vasculitis

 

Last Updated: 26 Sep 2016

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