Madelung's disease

Common Name(s)

Madelung's disease, Multiple symmetric lipomatosis, Launois-Bensaude adenolipomatosis, Familial symmetric lipomatosis

Madelung disease is a rare condition characterized by the symmetric growth of fatty tumors (lipomas) around the neck, shoulders, upper arms and/or upper trunk. It most often affects men of Mediterranean ancestry between the ages of 30 and 70 who have a history of alcohol abuse. Non-alcoholics and women can also be affected. The signs and symptoms vary greatly from person to person. Usually, accumulation of fatty tissue increases over time and may lead to a loss of neck mobility and pain. The lipomas can cause physical deformity and peripheral neuropathy. In the majority of cases, the disease is benign; however, lipomas can become cancerous in rare circumstances. The exact cause of Madelung disease is unknown, but it may be associated with changes (mutations) in mitochondrial DNA and/or alcoholism. Treatment may include medications to correct associated metabolic conditions; surgery or liposuction to remove the lipomas; and avoidance of alcohol.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Madelung's disease" for support, advocacy or research.

Fat Disorders Research Society

FDRS is dedicated to improving the quality of life for all people affected by adipose tissue disorders such as lipedema, lipoedema, Dercum's Disease, Madelung's Disease and Familial Multiple Lipomatosis, through research, education, advocacy and collaboration.

Last Updated: 9 Mar 2015

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Madelung's disease" for support, advocacy or research.

Fat Disorders Research Society

FDRS is dedicated to improving the quality of life for all people affected by adipose tissue disorders such as lipedema, lipoedema, Dercum's Disease, Madelung's Disease and Familial Multiple Lipomatosis, through research, education, advocacy and collaboration.

http://www.fatdisorders.org

Last Updated: 9 Mar 2015

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Madelung's disease" returned 16 free, full-text research articles on human participants. First 3 results:

IMAGES IN CLINICAL MEDICINE. Madelung's Disease.
 

Author(s): Giuseppe Nisi, Andrea Sisti

Journal: N. Engl. J. Med.. 2016 Feb;374(6):572.

 

Last Updated: 31 Dec 1969

Go To URL
State of diagnostic quandary solved by modern technology: a rare case of Madelung's disease.
 

Author(s): Htoo Kyaw, Michael Grillo, Aung Naing Lin, David A Kapp

Journal:

 

Madelung's disease is a neglected metabolic disease characterised by generalised multiple fatty tissue deposits. A 64-year-old Caucasian woman presented with generalised weakness and symptomatic hypoglycaemia with altered mental status. Physical examination showed very distinct physical ...

Last Updated: 31 Dec 1969

Go To URL
Multiple symmetrical lipomatosis (Madelung's disease).
 

Author(s): Ísis Ikumi Shibasaki, Hélder Ikuo Shibasaki, Tiago de Souza Nakamoto, Flávia Scarinci Baccan, Luiz Sergio Raposo

Journal: Braz J Otorhinolaryngol. ;80(1):90-1.

 

Last Updated: 31 Dec 1969

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Madelung's disease" returned 1 free, full-text review articles on human participants. First 3 results:

Madelung's disease as a rare cause of obstructive sleep apnea.
 

Author(s): Vitor Alexandre Oliveira Fonseca, Carlos Alves, Helena Marques, Elvira Camacho, António Pinto Saraiva

Journal: J Bras Pneumol. 2009 Oct;35(10):1053-6.

 

Madelung's disease, or multiple symmetric lipomatosis, is a rare disease, characterized by accumulation of unencapsulated fat, generally located symmetrically around the neck and shoulders. Here, we present the case of a patient with diffuse lipomatosis accompanied by obstructive ...

Last Updated: 31 Dec 1969

Go To URL
 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Identification of Mutations Responsible for Rare Familial Skin Diseases by Next Generation Sequencing
 

Status: Recruiting

Condition Summary: Familial Lipomatosis; Very Rare Dermatologic Diseases

 

Last Updated: 7 Oct 2016

Go to URL
Insight Into Subcutaneous Adipose Tissue Disorders
 

Status: Recruiting

Condition Summary: Lipedema; Dercum's Disease; Familial Multiple Lipomatosis; Madelung's Disease

 

Last Updated: 14 Sep 2017

Go to URL
Evaluation of Safety and Efficacy of RZL-012 for the Treatment of Lipedema or of Nodular Dercum's Disease
 

Status: Not yet recruiting

Condition Summary: Lipedema; Dercum Disease

 

Last Updated: 8 Apr 2018

Go to URL