Felty's Syndrome

Common Name(s)

Felty's Syndrome

Felty's syndrome is a rare, potentially serious disorder that is defined by the presence of three conditions: rheumatoid arthritis (RA), an enlarged spleen (splenomegaly) and a decreased white blood cell count (neutropenia), which causes repeated infections. Although some individuals with Felty's syndrome are asymptomatic, others can develop serious and life-threatening infections. Symptoms of Felty's syndrome, in addition to those associated with the three conditions stated above, may include fatigue, fever, weight loss, discoloration of patches of skin, mild hepatomegaly (enlarged liver), lymphadenopathy (swelling of lymph nodes), Sjšgren syndrome, vasculitis, lower-extremity ulcers, and other findings. The exact cause is unknown, but several risk factors have been proposed, including autoimmunity. A few familial cases of the condition have been reported. Treatment typically focuses on controlling the underlying RA; immunosuppressive therapy for RA may improve neutropenia and splenomegaly.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Felty's Syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Felty's Syndrome" returned 68 free, full-text research articles on human participants. First 3 results:

Non-articular Felty's syndrome: An uncommon diagnosis.
 

Author(s): T Jain, C Mittal, R Sengupta, B Rubin

Journal: Neth J Med. 2015 Nov;73(9):435-6.

 

Felty's syndrome is a triad of rheumatoid arthritis, neutropenia, and splenomegaly. We hereby report an unusual case of non-articular Felty's syndrome and its management along with discussing the importance of appropriately ruling out alternate causes of neutropenia with splenomegaly.

Last Updated: 31 Dec 1969

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A Case of Felty's Syndrome Associated with Skin Ulcers and Extranodal NK/T-cell Lymphoma.
 

Author(s): En Shu, Hiroyuki Kanoh, Yusuke Kito, Mariko Seishima

Journal: Acta Derm. Venereol.. 2015 Jul;95(6):754-5.

 

Last Updated: 31 Dec 1969

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Felty's syndrome autoantibodies bind to deiminated histones and neutrophil extracellular chromatin traps.
 

Author(s): Nishant Dwivedi, Jagriti Upadhyay, Indira Neeli, Salar Khan, Debendra Pattanaik, Linda Myers, Kyriakos A Kirou, Bernhard Hellmich, Bryan Knuckley, Paul R Thompson, Mary K Crow, Ted R Mikuls, Elena Csernok, Marko Radic

Journal: Arthritis Rheum.. 2012 Apr;64(4):982-92.

 

To test the hypothesis that autoantigen modifications by peptidylarginine deiminase type 4 (PAD-4) increase immunoreactivity.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Felty's Syndrome" returned 3 free, full-text review articles on human participants. First 3 results:

Neutrophil activation and B-cell stimulation in the pathogenesis of Felty's syndrome.
 

Author(s): Nishant Dwivedi, Marko Radic

Journal: Pol. Arch. Med. Wewn.. 2012 ;122(7-8):374-9.

 

Felty's syndrome (FS) is a severe arthritic disorder that features chronic neutrophil activation and progresses to neutropenia and susceptibility to unabated infections. The life‑threatening manifestations of FS have focused the attention of clinical experimenters who have made ...

Last Updated: 31 Dec 1969

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The spectrum of large granular lymphocyte leukemia and Felty's syndrome.
 

Author(s): Xin Liu, Thomas P Loughran

Journal: Curr. Opin. Hematol.. 2011 Jul;18(4):254-9.

 

Patients with chronic large granular lymphocyte (LGL) leukemia often have rheumatoid arthritis (RA), neutropenia and splenomegaly, thereby resembling the manifestations observed in patients with Felty's syndrome, which is a rare complication of RA characterized by neutropenia and ...

Last Updated: 31 Dec 1969

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Etanercept in treatment of Felty's syndrome.
 

Author(s): A Ghavami, S Genevay, T Fulpius, C Gabay

Journal: Ann. Rheum. Dis.. 2005 Jul;64(7):1090-1.

 

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.