Fibrosing Mediastinitis

Common Name(s)

Fibrosing Mediastinitis

Fibrosing mediastinitis is a condition that affects the area between the lungs (mediastinum) which contains the heart, large blood vessels, windpipe (trachea), esophagus, and lymph nodes. People with fibrosing mediastinitis have varying amounts of scar tissue in the mediastinum which may cause problems for the organs located there. For example, some affected people may develop blocked airways that can interfere with lung function. Others may have compressed blood vessels which can slow or prevent blood flow to and from the heart. The exact cause of fibrosing mediastinitis is not fully understood, but it is not inherited. Many cases are linked to a specific type of fungal infection called histoplasmosis. Treatment depends on which structures of the mediastinum are affected, the severity of the scarring and, in some cases, the cause of the condition.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Fibrosing Mediastinitis" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Fibrosing Mediastinitis" returned 29 free, full-text research articles on human participants. First 3 results:

Clinical Manifestations of Fibrosing Mediastinitis in Chinese Patients.
 

Author(s): Yan Hu, Jian-Xing Qiu, Ji-Ping Liao, Hong Zhang, Zhe Jin, Guang-Fa Wang

Journal: Chin. Med. J.. 2016 11;129(22):2697-2702.

 

Fibrosing mediastinitis (FM) is a rare disease. FM is thought to be related to prior granulomatous mediastinal infection, such as histoplasmosis or tuberculosis. The majority of cases have been reported in endemic regions for histoplasmosis. The characteristics of cases of FM in China, ...

Last Updated: 8 Nov 2016

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Pulmonary Hypertension Complicating Fibrosing Mediastinitis.
 

Author(s): Andrei Seferian, Alexandru Steriade, Xavier Jaïs, Olivier Planché, Laurent Savale, Florence Parent, David Amar, Roland Jovan, Elie Fadel, Olivier Sitbon, Gérald Simonneau, Marc Humbert, David Montani

Journal: Medicine (Baltimore). 2015 Nov;94(44):e1800.

 

Fibrosing mediastinitis is caused by a proliferation of fibrous tissue in the mediastinum with encasement of mediastinal viscera and compression of mediastinal bronchovascular structures. Pulmonary hypertension (PH) is a severe complication of fibrosing mediastinitis caused by extrinsic ...

Last Updated: 11 Nov 2015

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Fibrosing mediastinitis complicating prior histoplasmosis is associated with human leukocyte antigen DQB1*04:02 - a case control study.
 

Author(s): Stephen B Strock, Silvana Gaudieri, Simon Mallal, Chang Yu, Daphne Mitchell, Joy Cogan, Wendi Mason, Deborah Crowe, James E Loyd

Journal:

 

Fibrosing mediastinitis (FM) is an idiosyncratic reaction to infection with Histoplasma capsulatum with a prevalence of 3:100,000 people infected. The rarity of post-histoplasmosis fibrosing mediastinitis (PHFM) in areas where H. capsulatum is endemic suggests that an abnormal immunological ...

Last Updated: 9 May 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Fibrosing Mediastinitis" returned 1 free, full-text review articles on human participants. First 3 results:

Sarcoidosis-associated fibrosing mediastinitis with resultant pulmonary hypertension: a case report and review of the literature.
 

Author(s): Rebecca L Toonkel, Alain C Borczuk, Gregory D Pearson, Evelyn M Horn, Byron M Thomashow

Journal: Respiration. 2010 ;79(4):341-5.

 

Pulmonary hypertension, a common manifestation of advanced sarcoidosis, is thought to result from fibrosis with chronic hypoxia and destruction of small vessels, extrinsic compression of pulmonary arteries, or granulomatous vasculitis. We report a case of sarcoidosis-associated pulmonary ...

Last Updated: 5 Mar 2010

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Clinical Trial Information This information is provided by ClinicalTrials.gov

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