Fibrous Dysplasia

Common Name(s)

Fibrous Dysplasia

Fibrous dysplasia is a progressive bone disorder that is characterized by the replacement of normal bone with weaker tissues, such as fibrous tissue and woven bone.  It may involve one bone (monostotic) or multiple bones (polyostotic).   Though many individuals with this condition do not have any symptoms, others may have bone pain, abnormally shaped bones, or an increased risk of breaking bones.   This condition can occur alone or as part of a genetic disorder, such as McCune-Albright syndrome.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Fibrous Dysplasia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Fibrous Dysplasia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Fibrous Dysplasia" returned 224 free, full-text research articles on human participants. First 3 results:

Our experience in the surgical management of craniofacial fibrous dysplasia: what has changed in the last 10 years?
 

Author(s): V Valentini, A Cassoni, V Terenzi, M Della Monaca, M T Fadda, O Rajabtork Zadeh, I Raponi, A Anelli, G Iannetti

Journal: Acta Otorhinolaryngol Ital. 2017 Oct;37(5):436-443.

 

The mainstay of treatment of craniofacial dysplasia (CFD) remains surgery once clinical observation has been excluded. Nevertheless, disagreement remains about the type of surgical intervention (remodelling versus radical resection). The aim of this paper is to present our experience ...

Last Updated: 31 Dec 1969

Go To URL
Induced expression from the endogenous locus causes fibrous dysplasia by up-regulating Wnt/β-catenin signaling.
 

Author(s): Sanjoy Kumar Khan, Prem Swaroop Yadav, Gene Elliott, Dorothy Zhang Hu, Ruoshi Xu, Yingzi Yang

Journal: Proc. Natl. Acad. Sci. U.S.A.. 2018 01;115(3):E418-E427.

 

Fibrous dysplasia (FD; Online Mendelian Inheritance in Man no. 174800) is a crippling skeletal disease caused by activating mutations of the gene, which encodes the stimulatory G protein Gα FD can lead to severe adverse conditions such as bone deformity, fracture, and severe pain, ...

Last Updated: 31 Dec 1969

Go To URL
The value of Tc-methylene diphosphonate single photon emission computed tomography/computed tomography in diagnosis of fibrous dysplasia.
 

Author(s): Linqi Zhang, Qiao He, Wei Li, Rusen Zhang

Journal:

 

Fibrous dysplasia (FD) is a rare benign bone disorder in which the normal bone is replaced by immature fibro-osseous tissue. However, some case reports have reported that FD showed significantly increased Tc-methylene diphosphonate (Tc-MDP) uptake on whole-body bone scintigraphy (WBS), ...

Last Updated: 31 Dec 1969

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Fibrous Dysplasia" returned 31 free, full-text review articles on human participants. First 3 results:

Different clinical presentation and management of temporal bone fibrous dysplasia in children.
 

Author(s): Józef Mierzwiński, Justyna Kosowska, Justyna Tyra, Karolina Haber, Maria Drela, Dariusz Paczkowski, Paweł Burduk

Journal:

 

Fibrous dysplasia is a slowly progressive benign fibro-osseous disorder that involves one or multiple bones with a unilateral distribution in most cases. It is a lesion of unknown etiology, uncertain pathogenesis, and diverse histopathology. Temporal bone involvement is the least ...

Last Updated: 31 Dec 1969

Go To URL
[Endoscopic transnasal surgery for giant fibrous dysplasia of the skull base, spreading to the right orbital cavity and nasopharynx (a case report and literature review)].
 

Author(s): A N Shkarubo, A Yu Lubnin, E Yu Bukharin, L V Shishkina, D N Andreev, K V Koval', I V Chernov, V V Karnaukhov

Journal: Zh Vopr Neirokhir Im N N Burdenko. ;81(1):81-87.

 

An extended endoscopic endonasal approach is increasingly used in surgical treatment of space-occupying skull base lesions. The international literature reports only 20 cases of surgical treatment for fibrous dysplasia (PD) of the skull base using the endoscopic endonasal approach. ...

Last Updated: 31 Dec 1969

Go To URL
Fibrous dysplasia of bone: craniofacial and dental implications.
 

Author(s): A B Burke, M T Collins, A M Boyce

Journal: Oral Dis. 2017 Sep;23(6):697-708.

 

Fibrous dysplasia (FD) is a rare bone disease caused by postzygotic somatic activating mutations in the GNAS gene, which lead to constitutive activation of adenylyl cyclase and elevated levels of cyclic AMP, which act on downstream signaling pathways and cause normal bone to be replaced ...

Last Updated: 31 Dec 1969

Go To URL
 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Interest of Serum Periostin Dosage in Patients With Bone Fibrous Dysplasia
 

Status: Recruiting

Condition Summary: Bone Fibrous Dysplasia

 

Last Updated: 15 Feb 2018

Go to URL
Fibrous Dysplasia, McCune-Albright Syndrome Patient Registry
 

Status: Recruiting

Condition Summary: Fibrous Dysplasia; McCune Albright Syndrome; Mazabraud Syndrome

 

Last Updated: 24 Jul 2017

Go to URL
Characterization of Diabetes Mellitus in Fibrous Dysplasia/McCune-Albright Syndrome
 

Status: Recruiting

Condition Summary: McCune-Albright Syndrome; Fibrous Dysplasia; Intraductal Papillary Mucinous Neoplasm; Diabetes Mellitus

 

Last Updated: 8 Aug 2018

Go to URL