Focal Segmental Glomerulosclerosis

Common Name(s)

Focal Segmental Glomerulosclerosis, Focal segmental glomerulosclerosis 1

Focal segmental glomerulosclerosis (FSGS) is a type of kidney disorder. It is characterized by scar tissue that forms in some of the glomeruli in the kidney. FSGS may cause non-specific signs and symptoms, including protein in the urine, elevated levels of creatinine, and swelling. In many cases the cause of FSGS can not be determined. Some cases are thought to be associated with congenital kidney defects, urine backing up into the kidneys, obesity, obstructive sleep apnea, sickle cell anemia, or viruses (e.g., HIV).   The goal of treatment is to control symptoms and prevent chronic kidney failure.  Even with treatment, many people with FSGS progress to kidney failure within 5 to 20 years.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Focal Segmental Glomerulosclerosis" for support, advocacy or research.

The NephCure Foundation

The NephCure Foundation is the only organization committed exclusively to support research seeking the cause of the potentially debilitating kidney disease Focal Segmental Glomerulosclerosis (FSGS) and Nephrotic Syndrome, improve treatment and find a cure.

Last Updated: 30 Jan 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Focal Segmental Glomerulosclerosis" for support, advocacy or research.

The NephCure Foundation

The NephCure Foundation is the only organization committed exclusively to support research seeking the cause of the potentially debilitating kidney disease Focal Segmental Glomerulosclerosis (FSGS) and Nephrotic Syndrome, improve treatment and find a cure.

http://www.nephcure.org

Last Updated: 30 Jan 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Focal Segmental Glomerulosclerosis" returned 326 free, full-text research articles on human participants. First 3 results:

A case report of CRB2 mutation identified in a Chinese boy with focal segmental glomerulosclerosis.
 

Author(s): Jiaojiao Fan, Rong Fu, Fuxian Ren, Junjie He, Shujing Wang, Mengfan Gou

Journal: Medicine (Baltimore). 2018 Sep;97(37):e12362.

 

Focal segmental glomerulosclerosis (FSGS) is a common disease resulting in end-stage renal disease. The incidence of FSGS is increasing in Western countries. The clinical manifestations include proteinuria, hypoproteinemia, oedema, and hypertension. Single-gene heritable mutations ...

Last Updated: 31 Dec 1969

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CCR2 antagonism leads to marked reduction in proteinuria and glomerular injury in murine models of focal segmental glomerulosclerosis (FSGS).
 

Author(s): Zhenhua Miao, Linda S Ertl, Dale Newland, Bin Zhao, Yu Wang, Xiaoping Zang, James J Campbell, Xiaoli Liu, Ton Dang, Shichang Miao, Antoni Krasinski, Sreenivas Punna, Yibin Zeng, Jeffrey McMahon, Penglie Zhang, Israel F Charo, Thomas J Schall, Rajinder Singh

Journal:

 

Focal segmental glomerulosclerosis (FSGS) comprises a group of uncommon disorders that present with marked proteinuria, nephrotic syndrome, progressive renal failure and characteristic glomerular lesions on histopathology. The current standard of care for patients with FSGS include ...

Last Updated: 31 Dec 1969

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Focal segmental glomerulosclerosis in children complicated by posterior reversible encephalopathy syndrome.
 

Author(s): Magdalena Stârcea, Cristina Gavrilovici, Mihaela Munteanu, Ingrith Miron

Journal: J. Int. Med. Res.. 2018 Mar;46(3):1172-1177.

 

An uncommon side effect of cyclosporine A (CsA) use is posterior reversible encephalopathy syndrome (PRES). PRES usually develops because of disturbed capacity of posterior cerebral blood flow to autoregulate an acute rise in blood pressure. We present the case of a 10-year-old girl ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Focal Segmental Glomerulosclerosis" returned 45 free, full-text review articles on human participants. First 3 results:

Pregnancy, Proteinuria, Plant-Based Supplemented Diets and Focal Segmental Glomerulosclerosis: A Report on Three Cases and Critical Appraisal of the Literature.
 

Author(s): Rossella Attini, Filomena Leone, Benedetta Montersino, Federica Fassio, Fosca Minelli, Loredana Colla, Maura Rossetti, Cristiana Rollino, Maria Grazia Alemanno, Antonella Barreca, Tullia Todros, Giorgina Barbara Piccoli

Journal:

 

Chronic kidney disease (CKD) is increasingly recognized in pregnant patients. Three characteristics are associated with a risk of preterm delivery or small for gestational age babies; kidney function reduction, hypertension, and proteinuria. In pregnancy, the anti-proteinuric agents ...

Last Updated: 31 Dec 1969

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Focal Segmental Glomerulosclerosis.
 

Author(s): Avi Z Rosenberg, Jeffrey B Kopp

Journal: Clin J Am Soc Nephrol. 2017 Mar;12(3):502-517.

 

Focal segmental glomerulosclerosis (FSGS) is a leading cause of kidney disease worldwide. The presumed etiology of primary FSGS is a plasma factor with responsiveness to immunosuppressive therapy and a risk of recurrence after kidney transplant-important disease characteristics. In ...

Last Updated: 31 Dec 1969

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Soluble Urokinase Receptors in Focal Segmental Glomerulosclerosis: A Review on the Scientific Point of View.
 

Author(s): Andreas Kronbichler, Moin A Saleem, Björn Meijers, Jae Il Shin

Journal: J Immunol Res. 2016 ;2016():2068691.

 

Focal segmental glomerulosclerosis (FSGS) is one of the primary glomerular disorders in both children and adults which can progress to end-stage renal failure. Although there are genetic and secondary causes, circulating factors have also been regarded as an important factor in the ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Dose-Exploration Evaluating the Efficacy and Safety of Voclosporin in Subjects With Focal Segmental Glomerulosclerosis
 

Status: Recruiting

Condition Summary: Focal Segmental Glomerulosclerosis

 

Last Updated: 24 Jul 2018

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Safety and Effectiveness of Propagermanium in Focal Segmental Glomerulosclerosis Participants Receiving Irbesartan
 

Status: Not yet recruiting

Condition Summary: Focal Segmental Glomerulosclerosis

 

Last Updated: 26 Aug 2018

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FIRSTx - A Study of Oral CXA-10 in Primary Focal Segmental Glomerulosclerosis (FSGS)
 

Status: Recruiting

Condition Summary: Primary Focal Segmental Glomerulosclerosis

 

Last Updated: 18 Sep 2018

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