Focal segmental glomerulosclerosis 2

Common Name(s)

Focal segmental glomerulosclerosis 2

Focal segmental glomerulosclerosis (FSGS) is a pathologic entity associated clinically with proteinuria, the nephrotic syndrome (NPHS), and progressive loss of renal function. It is a common cause of end-stage renal disease (ESRD) (review by {1:Meyrier, 2005}). For a general phenotypic description and a discussion of genetic heterogeneity of focal segmental glomerulosclerosis and nephrotic syndrome (NPHS), see FSGS1 ({603278}).
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Focal segmental glomerulosclerosis 2" for support, advocacy or research.

The NephCure Foundation

The NephCure Foundation is the only organization committed exclusively to support research seeking the cause of the potentially debilitating kidney disease Focal Segmental Glomerulosclerosis (FSGS) and Nephrotic Syndrome, improve treatment and find a cure.

Last Updated: 30 Jan 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Focal segmental glomerulosclerosis 2" for support, advocacy or research.

The NephCure Foundation

The NephCure Foundation is the only organization committed exclusively to support research seeking the cause of the potentially debilitating kidney disease Focal Segmental Glomerulosclerosis (FSGS) and Nephrotic Syndrome, improve treatment and find a cure.

http://www.nephcure.org

Last Updated: 30 Jan 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Focal segmental glomerulosclerosis 2" returned 6 free, full-text research articles on human participants. First 3 results:

Familial focal segmental glomerulosclerosis: mutation in inverted formin 2 mimicking Alport syndrome.
 

Author(s): I M Rood, E M H F Bongers, D Lugtenberg, I H H T Klein, E J Steenbergen, J F M Wetzels, J K J Deegens

Journal: Neth J Med. 2016 Feb;74(2):82-5.

 

Focal segmental glomerulosclerosis (FSGS) is one of the most common patterns of glomerular injury. FSGS can be caused by mutations in genes encoding proteins that play key roles in the function of the podocyte and glomerular basement membrane. In this case report we present a family ...

Last Updated: 31 Dec 1969

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Janus kinase 2/signal transducer and activator of transcription 3 inhibitors attenuate the effect of cardiotrophin-like cytokine factor 1 and human focal segmental glomerulosclerosis serum on glomerular filtration barrier.
 

Author(s): Mukut Sharma, Jianping Zhou, Jean-Fran├žois Gauchat, Ram Sharma, Ellen T McCarthy, Tarak Srivastava, Virginia J Savin

Journal: Transl Res. 2015 Oct;166(4):384-98.

 

Recurrence of idiopathic focal segmental glomerulosclerosis (FSGS) after renal transplantation is believed to be caused by a circulating factor(s). We detected cardiotrophin-like cytokine factor 1 (CLCF1), a member of the interleukin 6 family, in the plasma from patients with recurrent ...

Last Updated: 31 Dec 1969

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Lack of renoprotective effect of chronic intravenous angiotensin-(1-7) or angiotensin-(2-10) in a rat model of focal segmental glomerulosclerosis.
 

Author(s): Juan Carlos Q Velez, Michael G Janech, Megan P Hicks, Thomas A Morinelli, Jessalyn Rodgers, Sally E Self, John M Arthur, Wayne R Fitzgibbon

Journal:

 

Unopposed angiotensin (Ang) II-mediated cellular effects may lead to progressive glomerulosclerosis. While Ang-II can be locally generated in the kidneys, we previously showed that glomerular podocytes primarily convert Ang-I, the precursor of Ang-II, to Ang-(1-7) and Ang-(2-10), ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Focal segmental glomerulosclerosis 2" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

A Study of Oral CXA-10 in Primary Focal Segmental Glomerulosclerosis (FSGS)
 

Status: Not yet recruiting

Condition Summary: Primary Focal Segmental Glomerulosclerosis

 

Last Updated: 14 Feb 2018

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Study to Assess the Efficacy and Safety of Bleselumab in Preventing the Recurrence of Focal Segmental Glomerulosclerosis in de Novo Kidney Transplant Recipients
 

Status: Recruiting

Condition Summary: Kidney Transplantation; Focal Segmental Glomerulosclerosis (FSGS)

 

Last Updated: 23 Jan 2018

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Treatment of Proteinuria Due to Treatment Resistant or Treatment Intolerant Idiopathic FSGS
 

Status: Recruiting

Condition Summary: Idiopathic Focal Segmental Glomerulosclerosis

 

Last Updated: 15 Dec 2017

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