Gastroesophageal reflux disease

Common Name(s)

Gastroesophageal reflux disease, GERD

Gastroesophageal reflux disease, or GERD, is caused by frequent acid reflux, which irritates the lining of the esophagus. GERD is generally diagnosed when a person experiences acid reflux more than two times per week.

Acid reflux is a common condition in which stomach acid flows up into the esophagus. This causes a burning, painful feeling in the chest more commonly known as heartburn or acid indigestion. Your stomach makes a strong acid to help break down food and to protect you from bacteria. The stomach is not harmed by the acid because it has a special lining. The esophagus is the tube that takes your food from your mouth to your stomach. It does not have the special lining, so it will be irritated by the stomach acid. Normally a special ring of muscle, the lower esophageal sphincter (LES), keeps the stomach’s contents from flowing up into the esophagus. Acid reflux happens most often when the LES is not working correctly.

Symptoms of acid reflux include heartburn, bitter or sour taste in the mouth, difficulty swallowing, a chronic dry cough, wheezing and hoarseness. The heartburn usually occurs after a meal, lasts several hours and worsens if you lie down. Although it is not clear what causes the LES to weaken, certain factors seem to increase the risk of developing acid reflux including obesity, pregnancy, having a hiatal hernia, smoking, drinking alcohol and caffeine, and taking certain medications. Certain types of foods may trigger an heartburn episode.

Risk factors for GERD include obesity, pregnancy, smoking, dry mouth, asthma, diabetes, and connective tissue disorders. If you are experiencing frequent acid reflux, making lifestyle changes to lower your risks may help so that GERD is not developed. If you believe you may have GERD, or if you are experiencing acid reflux frequently, seek medical attention. Support groups are available for more resources and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Gastroesophageal reflux disease" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Gastroesophageal reflux disease" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Gastroesophageal reflux disease" returned 464 free, full-text research articles on human participants. First 3 results:

Correlation between esophageal pH-metry and esophagitis in gastroesophageal reflux disease in children.
 

Author(s): Vasile Valeriu Lupu, Marin Burlea, Nicolai Nistor, Violeta Streanga, Magdalena Iuliana Starcea, Gabriela Paduraru, Dragos Catalin Ghica, Elena Cristina Mitrofan, Mihaela Moscalu, Ancuta Ignat

Journal: Medicine (Baltimore). 2018 Sep;97(37):e12042.

 

Gastroesophageal reflux (GER) is the intermittent or permanent passage of stomach content into the esophagus and gastroesophageal reflux disease (GERD) is the reflux which triggers a whole set of symptoms or complications. The study compares the 24-hours esophageal pH-metry, used ...

Last Updated: 31 Dec 1969

Go To URL
Mucosal Two-Step Pathogenesis in Gastroesophageal Reflux Disease: Repeated Weakly Acidic Stimulation and Activation of Protease-Activated Receptor-2 on Mucosal Interleukin-8 Secretion.
 

Author(s): Lukas Winkelsett, Peter Malfertheiner, Thomas Wex, Arne Kandulski

Journal: Digestion. 2018 ;98(1):19-25.

 

Activation of protease-activated receptor-2 (PAR2) is involved in the mucosal immune pathogenesis of gastroesophageal reflux disease (GERD) that is characterized by proinflammatory cytokines such as interleukin-8 (IL-8). PAR2 activation on epithelial cells induces epithelial IL-8 ...

Last Updated: 31 Dec 1969

Go To URL
Peroral endoscopic cardial constriction in gastroesophageal reflux disease.
 

Author(s): Hai-Qing Hu, Hui-Kai Li, Ying Xiong, Xiao-Bin Zhang, Jun-Li Zhi, Xiao-Xiao Wang, En-Qiang Ling-Hu

Journal: Medicine (Baltimore). 2018 Apr;97(15):e0169.

 

Gastroesophageal reflux disease (GERD) is a major digestive health problem with a high and increasing incidence worldwide. Peroral endoscopic cardial constriction (PECC) was developed by our group to provide a less invasive treatment for GERD.In this preliminary follow-up study, 16 ...

Last Updated: 31 Dec 1969

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Gastroesophageal reflux disease" returned 139 free, full-text review articles on human participants. First 3 results:

Vonoprazan versus proton pump inhibitors for the management of gastroesophageal reflux disease: A protocol for a systematic review with meta-analysis.
 

Author(s): Hyun Kang, Beom Jin Kim, Geunjoo Choi, Jae Gyu Kim

Journal: Medicine (Baltimore). 2018 Sep;97(39):e12574.

 

Vonoprazan, a novel potassium-competitive acid blocking agent, is used in the management of gastroesophageal reflux disease (GERD). We aim to perform a systematic review and meta-analysis for the comparison of the effects of vonoprazan and proton pump inhibitors (PPIs) in GERD in ...

Last Updated: 31 Dec 1969

Go To URL
New Minimally Invasive Endoscopic and Surgical Therapies for Gastroesophageal Reflux Disease (GERD).
 

Author(s): Alexandru Eugen Nicolau, Adrian Lobonţiu, Silviu Constantinoiu

Journal: Chirurgia (Bucur). ;113(1):70-82.

 

GERD has become one of the most frequent pathology of the upper GI tract. It is a spectrum disease and is a progressive disease as well. Serious and severe complications are possible. The mainstream therapy in most of the patients is the medical therapy with PPI's. The most severe ...

Last Updated: 31 Dec 1969

Go To URL
Evaluation of Esophageal Mucosal Integrity in Patients with Gastroesophageal Reflux Disease.
 

Author(s): Tomoaki Matsumura, Makoto Arai, Hideaki Ishigami, Mai Fujie, Kentaro Ishikawa, Naoki Akizue, Takashi Taida, Yuki Ohta, Shinsaku Hamanaka, Kenichiro Okimoto, Keiko Saito, Daisuke Maruoka, Tomoo Nakagawa, Naoya Kato

Journal: Digestion. 2018 ;97(1):31-37.

 

Impaired esophageal mucosal integrity plays a role in causing symptoms of gastroesophageal reflux disease (GERD). Recently, the assessment of esophageal baseline impedance (BI) using the multichannel intraluminal impedance-pH (MII-pH) test was suggested as a surrogate technique for ...

Last Updated: 31 Dec 1969

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Symptom Assessment for Patients With Gastro-esophageal Reflux Disease Receiving Helicobacter Pylori Eradication
 

Status: Not yet recruiting

Condition Summary: Gastroesophageal Reflux Disease

 

Last Updated: 17 Oct 2016

Go to URL
Radiofrequency Energy Delivery for Gastroesophageal Reflux Disease
 

Status: Recruiting

Condition Summary: Gastroesophageal Reflux Disease

 

Last Updated: 18 Jul 2017

Go to URL