Gastroesophageal reflux disease

Common Name(s)

Gastroesophageal reflux disease, GERD

Gastroesophageal reflux disease, or GERD, is caused by frequent acid reflux, which irritates the lining of the esophagus. GERD is generally diagnosed when a person experiences acid reflux more than two times per week.

Acid reflux is a common condition in which stomach acid flows up into the esophagus. This causes a burning, painful feeling in the chest more commonly known as heartburn or acid indigestion. Your stomach makes a strong acid to help break down food and to protect you from bacteria. The stomach is not harmed by the acid because it has a special lining. The esophagus is the tube that takes your food from your mouth to your stomach. It does not have the special lining, so it will be irritated by the stomach acid. Normally a special ring of muscle, the lower esophageal sphincter (LES), keeps the stomach’s contents from flowing up into the esophagus. Acid reflux happens most often when the LES is not working correctly.

Symptoms of acid reflux include heartburn, bitter or sour taste in the mouth, difficulty swallowing, a chronic dry cough, wheezing and hoarseness. The heartburn usually occurs after a meal, lasts several hours and worsens if you lie down. Although it is not clear what causes the LES to weaken, certain factors seem to increase the risk of developing acid reflux including obesity, pregnancy, having a hiatal hernia, smoking, drinking alcohol and caffeine, and taking certain medications. Certain types of foods may trigger an heartburn episode.

Risk factors for GERD include obesity, pregnancy, smoking, dry mouth, asthma, diabetes, and connective tissue disorders. If you are experiencing frequent acid reflux, making lifestyle changes to lower your risks may help so that GERD is not developed. If you believe you may have GERD, or if you are experiencing acid reflux frequently, seek medical attention. Support groups are available for more resources and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Gastroesophageal reflux disease" for support, advocacy or research.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Gastroesophageal reflux disease" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Gastroesophageal reflux disease" returned 402 free, full-text research articles on human participants. First 3 results:

Characteristics and Outcomes of Laparoscopic Surgery in Patients with Gastroesophageal Reflux and Related Disease: A Single Center Experience.
 

Author(s): Tsutomu Nomura, Katsuhiko Iwakiri, Takeshi Matsutani, Nobutoshi Hagiwara, Itsuo Fujita, Yoshiharu Nakamura, Yoshikazu Kanazawa, Hiroshi Makino, Noriyuki Kawami, Masao Miyashita, Eiji Uchida

Journal: J Nippon Med Sch. 2017 ;84(1):25-31.

 

Laparoscopic anti-reflux surgery (LARS) is generally the treatment of choice for patients with gastroesophageal reflux disease (GERD). This report describes our experiences in performing LARS on patients with GERD, and focuses retrospectively on the pathophysiology of individual patients ...

Last Updated: 23 Mar 2017

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Prevalence of gastroesophageal reflux disease in a country with a high occurrence of Helicobacter pylori.
 

Author(s): Serhat Bor, Gul Kitapcioglu, Elmas Kasap

Journal: World J. Gastroenterol.. 2017 Jan;23(3):525-532.

 

To evaluate the prevalence of gastroesophageal reflux disease (GERD) with additional symptoms, relationship with Helicobacter pylori (H. pylori) of this country-wide study.

Last Updated: 17 Feb 2017

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An analysis of 342 patients with refractory gastroesophageal reflux disease symptoms using questionnaires, high-resolution manometry, and impedance-pH monitoring.
 

Author(s): Fei Wang, Ping Li, Guo-Zhong Ji, Lin Miao, Zhining Fan, Sihong You, Xueqin Pan, Xia Chen

Journal: Medicine (Baltimore). 2017 Feb;96(5):e5906.

 

Symptoms of refractory gastroesophageal reflux disease (GERD) are commonly encountered in clinical practice. The aim of this study was to analyze the data obtained from questionnaires, high-resolution manometry (HRM), and ambulatory impedance-pH monitoring in patients with persisting ...

Last Updated: 2 Feb 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Gastroesophageal reflux disease" returned 111 free, full-text review articles on human participants. First 3 results:

Diagnosis and treatment of gastroesophageal reflux disease: recommendations of the Asociación Mexicana de Gastroenterología.
 

Author(s): F Huerta-Iga, M V Bielsa-Fernández, J M Remes-Troche, M A Valdovinos-Díaz, J L Tamayo-de la Cuesta,

Journal: Rev Gastroenterol Mex. ;81(4):208-222.

 

Emerging concepts in the pathophysiology of gastroesophageal reflux disease (GERD) and the constant technologic advances in the diagnosis and treatment of this clinical condition make it necessary to frequently review and update the clinical guidelines, recommendations, and official ...

Last Updated: 17 Sep 2016

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Efficacy of acid suppression therapy in gastroesophageal reflux disease-related chronic laryngitis.
 

Author(s): Yue Yang, Haitao Wu, Jian Zhou

Journal: Medicine (Baltimore). 2016 Oct;95(40):e4868.

 

This research aims to assess the response to acid suppression therapy in gastroesophageal reflux disease (GERD)-related chronic laryngitis (CL).

Last Updated: 17 Oct 2016

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[Current Status of Translational Research on Gastroesophageal Reflux Disease].
 

Author(s): In Du Jeong, Moo In Park

Journal: Korean J Gastroenterol. 2016 Sep;68(3):127-31.

 

The prevalence of gastroesophageal reflux disease (GERD) and the incidence of some of its complications have risen strikingly over the last few decades. With the increase in our understanding of the pathophysiology of GERD along with the development of proton pump inhibitors, the ...

Last Updated: 20 Sep 2016

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Symptom Assessment for Patients With Gastro-esophageal Reflux Disease Receiving Helicobacter Pylori Eradication
 

Status: Not yet recruiting

Condition Summary: Gastroesophageal Reflux Disease

 

Last Updated: 17 Oct 2016

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Impact of Head of Bed Elevation in Symptoms of Patients With Gastroesophageal Reflux Disease
 

Status: Recruiting

Condition Summary: Gastroesophageal Reflux Disease

 

Last Updated: 25 Oct 2016

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Outcomes After Medical and Surgical Treatment of Gastroesophageal Reflux Disease
 

Status: Recruiting

Condition Summary: Gastroesophageal Reflux Disease

 

Last Updated: 13 Jul 2017

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