Gastroesophageal reflux disease

Common Name(s)

Gastroesophageal reflux disease, GERD

Gastroesophageal reflux disease, or GERD, is caused by frequent acid reflux, which irritates the lining of the esophagus. GERD is generally diagnosed when a person experiences acid reflux more than two times per week.

Acid reflux is a common condition in which stomach acid flows up into the esophagus. This causes a burning, painful feeling in the chest more commonly known as heartburn or acid indigestion. Your stomach makes a strong acid to help break down food and to protect you from bacteria. The stomach is not harmed by the acid because it has a special lining. The esophagus is the tube that takes your food from your mouth to your stomach. It does not have the special lining, so it will be irritated by the stomach acid. Normally a special ring of muscle, the lower esophageal sphincter (LES), keeps the stomach’s contents from flowing up into the esophagus. Acid reflux happens most often when the LES is not working correctly.

Symptoms of acid reflux include heartburn, bitter or sour taste in the mouth, difficulty swallowing, a chronic dry cough, wheezing and hoarseness. The heartburn usually occurs after a meal, lasts several hours and worsens if you lie down. Although it is not clear what causes the LES to weaken, certain factors seem to increase the risk of developing acid reflux including obesity, pregnancy, having a hiatal hernia, smoking, drinking alcohol and caffeine, and taking certain medications. Certain types of foods may trigger an heartburn episode.

Risk factors for GERD include obesity, pregnancy, smoking, dry mouth, asthma, diabetes, and connective tissue disorders. If you are experiencing frequent acid reflux, making lifestyle changes to lower your risks may help so that GERD is not developed. If you believe you may have GERD, or if you are experiencing acid reflux frequently, seek medical attention. Support groups are available for more resources and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Gastroesophageal reflux disease" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Gastroesophageal reflux disease" returned 441 free, full-text research articles on human participants. First 3 results:

Peroral endoscopic cardial constriction in gastroesophageal reflux disease.
 

Author(s): Hai-Qing Hu, Hui-Kai Li, Ying Xiong, Xiao-Bin Zhang, Jun-Li Zhi, Xiao-Xiao Wang, En-Qiang Ling-Hu

Journal: Medicine (Baltimore). 2018 Apr;97(15):e0169.

 

Gastroesophageal reflux disease (GERD) is a major digestive health problem with a high and increasing incidence worldwide. Peroral endoscopic cardial constriction (PECC) was developed by our group to provide a less invasive treatment for GERD.In this preliminary follow-up study, 16 ...

Last Updated: 31 Dec 1969

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Gastroesophageal reflux disease in patients with long standing type 1 diabetes mellitus: utility of two self-report questionnaires in a multifactorial disease.
 

Author(s): Emmanuel Marin Valdez-Solis, Claudia Ramírez-Rentería, Aldo Ferreira-Hermosillo, Mario Molina-Ayala, Victoria Mendoza-Zubieta, Víctor Rodríguez-Pérez

Journal:

 

Gastroesophageal pathologies are common and multifactorial in patients with type 1 diabetes (T1DM). The evaluation with endoscopy and 24 h pH esophageal monitoring is expensive and not always available in all medical centers, especially in developing countries so more cost-effective ...

Last Updated: 31 Dec 1969

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The comparative analyses of different diagnostic approaches in detection of gastroesophageal reflux disease in children.
 

Author(s): Nina Ristic, Ivan Milovanovic, Milica Radusinovic, Marija Stevic, Milos Ristic, Maja Ristic, Darija Kisic Tepavcevic, Tamara Alempijevic

Journal:

 

The aim of this study was to compare the different diagnostic approaches in detection of gastroesophageal reflux disease in children presented with symptoms suggesting gastroesophageal reflux disease.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Gastroesophageal reflux disease" returned 123 free, full-text review articles on human participants. First 3 results:

ANTISECRETORY TREATMENT FOR PEDIATRIC GASTROESOPHAGEAL REFLUX DISEASE - A SYSTEMATIC REVIEW.
 

Author(s): Ângelo Zambam de Mattos, Gabriela Meirelles Marchese, Bárbara Brum Fonseca, Carlos Kupski, Marta Brenner Machado

Journal: Arq Gastroenterol. 2017 Dec;54(4):271-280.

 

Proton pump inhibitors and histamine H2 receptor antagonists are two of the most commonly prescribed drug classes for pediatric gastroesophageal reflux disease, but their efficacy is controversial. Many patients are treated with these drugs for atypical manifestations attributed to ...

Last Updated: 31 Dec 1969

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Efficacy of Magnetic Sphincter Augmentation versus Nissen Fundoplication for Gastroesophageal Reflux Disease in Short Term: A Meta-Analysis.
 

Author(s): Ming-Yu Chen, Di-Yu Huang, Angela Wu, Yi-Bin Zhu, He-Pan Zhu, Liu-Mei Lin, Xiu-Jun Cai

Journal: Can J Gastroenterol Hepatol. 2017 ;2017():9596342.

 

. The efficacy of Magnetic Sphincter Augmentation (MSA) and its outcomes for Gastroesophageal Reflux Disease (GERD) are uncertain. Therefore, we aimed to summarize and analyze the efficacy of two treatments for GERD. . The meta-analysis search was performed, using four databases. ...

Last Updated: 31 Dec 1969

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The Quality of Care for Gastroesophageal Reflux Disease.
 

Author(s): Rena Yadlapati, Lara Dakhoul, John E Pandolfino, Rajesh N Keswani

Journal: Dig. Dis. Sci.. 2017 03;62(3):569-576.

 

Improving the quality of healthcare delivery is a cornerstone of modern medical care shared between all stakeholders. However, effectively improving quality requires both an understanding of the tenets of healthcare quality and how they relate to an individual disease process. This ...

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Symptom Assessment for Patients With Gastro-esophageal Reflux Disease Receiving Helicobacter Pylori Eradication
 

Status: Not yet recruiting

Condition Summary: Gastroesophageal Reflux Disease

 

Last Updated: 17 Oct 2016

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Impact of Head of Bed Elevation in Symptoms of Patients With Gastroesophageal Reflux Disease
 

Status: Recruiting

Condition Summary: Gastroesophageal Reflux Disease

 

Last Updated: 25 Oct 2016

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Radiofrequency Energy Delivery for Gastroesophageal Reflux Disease
 

Status: Recruiting

Condition Summary: Gastroesophageal Reflux Disease

 

Last Updated: 18 Jul 2017

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