Gallbladder cancer

Common Name(s)

Gallbladder cancer

Gallbladder cancer is a type of cancer that begins in the gallbladder, an organ under the liver in the upper abdomen. The gallbladder stores bile, which is made by the liver for fat digestion. Signs of gallbladder cancer include yellowing of the skin or eyes (jaundice), pain in the upper right part of the abdomen, fever, nausea, vomiting, bloating, weight loss, loss of appetite, itchiness, and lumps in the abdomen.

Gallbladder cancer occurs when cells in the gallbladder develop mutations that result in the cells dividing rapidly and resisting death. Those cells form a tumor. Being female and being Native American increases one’s risk of developing gallbladder cancer. Other risk factors include being older, obesity, and having a history of gallstones.

Because the symptoms are consistent with those of many other diseases, gallbladder cancer is difficult to detect early. With that said, there are several tests used to diagnose gallbladder cancer. High levels of a chemical in bile called bilirubin are a sign of gallbladder cancer and can be detected through blood tests. Tumor markers, or proteins that present in the blood with certain cancers, may also be detected by blood tests. X-ray imaging, computed tomography (CT) scans, magnetic resonance imaging (MRI) scans, and ultrasounds can also be used to diagnose gallbladder cancer. Additional tests may be performed to determine the stage of the disease.

Treatment for gallbladder cancer often involves surgical removal of the gallbladder and surrounding tissues in a procedure called a cholecystectomy. If the cancer cannot be removed, symptoms may be lessened through additional surgery, chemotherapy, radiation therapy, or clinical trials. If you have been diagnosed with gallbladder cancer, talk to your doctor about the most current treatment options. Support groups are available for more resources and information.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Gallbladder cancer" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Gallbladder cancer" returned 285 free, full-text research articles on human participants. First 3 results:

Subtypes of Native American ancestry and leading causes of death: Mapuche ancestry-specific associations with gallbladder cancer risk in Chile.
 

Author(s): Justo Lorenzo Bermejo, Felix Boekstegers, Rosa González Silos, Katherine Marcelain, Pablo Baez Benavides, Carol Barahona Ponce, Bettina Müller, Catterina Ferreccio, Jill Koshiol, Christine Fischer, Barbara Peil, Janet Sinsheimer, Macarena Fuentes Guajardo, Olga Barajas, Rolando Gonzalez-Jose, Gabriel Bedoya, Maria Cátira Bortolini, Samuel Canizales-Quinteros, Carla Gallo, Andres Ruiz Linares, Francisco Rothhammer

Journal:

 

Latin Americans are highly heterogeneous regarding the type of Native American ancestry. Consideration of specific associations with common diseases may lead to substantial advances in unraveling of disease etiology and disease prevention. Here we investigate possible associations ...

Last Updated: 25 May 2017

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MYBL2 is a Potential Prognostic Marker that Promotes Cell Proliferation in Gallbladder Cancer.
 

Author(s): Hai-Bin Liang, Yang Cao, Qiang Ma, Yi-Jun Shu, Zheng Wang, Fei Zhang, Yuan-Yuan Ye, Huai-Feng Li, Shan-Shan Xiang, Xiao-Ling Song, Yi Xu, Yi-Chi Zhang, Run-Fa Bao, Rui-Yan Yuan, Yi-Jian Zhang, Yun-Ping Hu, Lin Jiang, Mao-Lan Li, Xu-An Wang, Xiang-Song Wu, Wen-Guang Wu, Shuai Zhao, Yong Fand, Xiao-Peng Cui, Yun-Shu Lu, Jian Zhou, Lei Zheng, Wei Gong, Ying-Bin Liu

Journal: Cell. Physiol. Biochem.. 2017 ;41(5):2117-2131.

 

Gallbladder cancer (GBC) is an aggressive and highly lethal biliary tract malignancy, with extremely poor prognosis. In the present study, we analyzed the potential involvement of MYBL2, a member of the Myb transcription factor family, in the carcinogenesis of human GBC.

Last Updated: 20 Apr 2017

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Chloride intracellular channel 1 regulates the antineoplastic effects of metformin in gallbladder cancer cells.
 

Author(s): Yongchen Liu, Zheng Wang, Maolan Li, Yuanyuan Ye, Yi Xu, Yichi Zhang, Ruiyan Yuan, Yunpeng Jin, Yajuan Hao, Lin Jiang, Yunping Hu, Shili Chen, Fatao Liu, Yijian Zhang, Wenguang Wu, Yingbin Liu

Journal: Cancer Sci.. 2017 Jun;108(6):1240-1252.

 

Metformin is the most commonly used drug for type 2 diabetes and has potential benefit in treating and preventing cancer. Previous studies indicated that membrane proteins can affect the antineoplastic effects of metformin and may be crucial in the field of cancer research. However, ...

Last Updated: 5 Apr 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Gallbladder cancer" returned 29 free, full-text review articles on human participants. First 3 results:

Gallbladder cancer: South American experience.
 

Author(s): Gerardo F Arroyo, Alberto Gentile, Luis A Parada

Journal: Chin Clin Oncol. 2016 Oct;5(5):67.

 

Large differences in terms of incidence and mortality due to gallbladder cancer (GBC) have been reported worldwide. Moreover, it seems that GBC has unique characteristics in South America. We surveyed the literature looking for information about the epidemiology, basic and translational ...

Last Updated: 10 Nov 2016

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Technical Aspects of Gallbladder Cancer Surgery.
 

Author(s): Motaz Qadan, T Peter Kingham

Journal: Surg. Clin. North Am.. 2016 Apr;96(2):229-45.

 

In this review, the authors present an updated description of gallbladder cancer in 2 sections based on presentation: disease that presents incidentally following laparoscopic cholecystectomy and malignancy that is suspected preoperatively. Elements pertaining to technical aspects ...

Last Updated: 28 Mar 2016

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Genomics of gallbladder cancer: the case for biomarker-driven clinical trial design.
 

Author(s): Jason K Sicklick, Paul T Fanta, Kelly Shimabukuro, Razelle Kurzrock

Journal: Cancer Metastasis Rev.. 2016 06;35(2):263-75.

 

Gallbladder carcinoma is a rare, aggressive malignancy of the biliary tract associated with a poor prognosis. Despite the deployment of targeted therapies that have demonstrated marked survival benefits in many tumor types, traditional cytotoxic chemotherapy has remained the mainstay ...

Last Updated: 17 Jun 2016

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Clinical Trial Information This information is provided by ClinicalTrials.gov

The Effect in Wedge Resection and IVb/V Resection of the Liver for Gallbladder Cancer
 

Status: Recruiting

Condition Summary: Gallbladder Cancer

 

Last Updated: 28 Sep 2016

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Last Updated: 13 Aug 2016

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Adjuvant Chemotherapy vs no Chemotherapy for Patients With GallBllader Carcinoma
 

Status: Recruiting

Condition Summary: Gallbladder Cancer

 

Last Updated: 18 May 2016

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