Gamma Heavy Chain Disease

Common Name(s)

Gamma Heavy Chain Disease

Gamma heavy chain disease is characterized by the abnormal production of antibodies. Antibodies are made up of light chains and heavy chains. In this disorder, the heavy chain of the gamma antibody (IgG) is overproduced by the body.  Gamma heavy chain disease mainly affects older adults and is similar to aggressive malignant (cancerous) lymphoma. However, some people with this disorder have no symptoms. People with symptoms may respond to chemotherapy drugs, corticosteroids, and radiation therapy. Approximately one-third of individuals with gamma heavy chain disease are also diagnosed with an autoimmune disorder.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Gamma Heavy Chain Disease" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Gamma Heavy Chain Disease" returned 23 free, full-text research articles on human participants. First 3 results:

A unique case of γ-heavy chain deposition disease characterized by concomitant deposition of γ2 and γ4 subclasses.
 

Author(s): Guang Yin, Yan Wu, Cai-Hong Zeng, Hui-Ping Chen, Zhi-Hong Liu

Journal: Intern. Med.. 2014 ;53(22):2615-8.

 

Heavy chain deposition disease (HCDD) is a rare entity. γ-HCDD is the predominant subtype and is characterized by glomerular and tubular deposition of a single γ-heavy chain subclass. To our knowledge, γ-HCDD with simultaneous deposition of two subclasses has not yet been described. ...

Last Updated: 17 Nov 2014

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Gamma heavy chain disease lacks the MYD88 L265p mutation associated with lymphoplasmacytic lymphoma.
 

Author(s): Fatima Hamadeh, Stephen MacNamara, Chris M Bacon, Aliyah R Sohani, Steven H Swerdlow, James R Cook

Journal: Haematologica. 2014 Sep;99(9):e154-5.

 

Last Updated: 1 Sep 2014

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Gamma heavy chain disease in a patient with rheumatoid arthritis--a laboratory evaluation.
 

Author(s): Wibke Johannis, Jenny Blommer, Andreas R Klatt, Joerg H Renno, Klaus Wielckens

Journal: Biochem Med (Zagreb). 2012 ;22(3):373-9.

 

Heavy chain diseases (HCD) are neoplastic proliferations of B cells which secrete truncated immunoglobulin heavy chains without associated light chains. Being rare and probably underdiagnosed diseases the aim of this report is to show an additional case of gamma heavy chain disease ...

Last Updated: 24 Oct 2012

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Gamma Heavy Chain Disease" returned 1 free, full-text review articles on human participants. First 3 results:

Gamma Heavy Chain Disease with T-cell Large Granular Lymphocytic Leukemia: A Case Report and Review of the Literature.
 

Author(s): Masahide Iijima, Naohiro Sekiguchi, Akihisa Nagata, Miyuki Wagatsuma, Kiyoe Midorikawa, Miwa Kurimoto, Satoshi Noto, Kazuaki Yamada, Naoki Takezako

Journal: Intern. Med.. 2016 ;55(4):399-403.

 

Gamma heavy chain disease (gHCD) is a rare lymphoproliferative disorder characterized by the production of a truncated immunoglobulin heavy chain. Although some cases of gHCD are concurrent with other lymphoid neoplasms, few have been reported. We herein present the case of a 73-year-old ...

Last Updated: 15 Feb 2016

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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.