Gastroesophageal reflux disease

Common Name(s)

Gastroesophageal reflux disease, GERD

Gastroesophageal reflux disease, or GERD, is caused by frequent acid reflux, which irritates the lining of the esophagus. GERD is generally diagnosed when a person experiences acid reflux more than two times per week.

Acid reflux is a common condition in which stomach acid flows up into the esophagus. This causes a burning, painful feeling in the chest more commonly known as heartburn or acid indigestion. Your stomach makes a strong acid to help break down food and to protect you from bacteria. The stomach is not harmed by the acid because it has a special lining. The esophagus is the tube that takes your food from your mouth to your stomach. It does not have the special lining, so it will be irritated by the stomach acid. Normally a special ring of muscle, the lower esophageal sphincter (LES), keeps the stomach’s contents from flowing up into the esophagus. Acid reflux happens most often when the LES is not working correctly.

Symptoms of acid reflux include heartburn, bitter or sour taste in the mouth, difficulty swallowing, a chronic dry cough, wheezing and hoarseness. The heartburn usually occurs after a meal, lasts several hours and worsens if you lie down. Although it is not clear what causes the LES to weaken, certain factors seem to increase the risk of developing acid reflux including obesity, pregnancy, having a hiatal hernia, smoking, drinking alcohol and caffeine, and taking certain medications. Certain types of foods may trigger an heartburn episode.

Risk factors for GERD include obesity, pregnancy, smoking, dry mouth, asthma, diabetes, and connective tissue disorders. If you are experiencing frequent acid reflux, making lifestyle changes to lower your risks may help so that GERD is not developed. If you believe you may have GERD, or if you are experiencing acid reflux frequently, seek medical attention. Support groups are available for more resources and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Gastroesophageal reflux disease" for support, advocacy or research.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Gastroesophageal reflux disease" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Gastroesophageal reflux disease" returned 419 free, full-text research articles on human participants. First 3 results:

Factors associated with residual gastroesophageal reflux disease symptoms in patients receiving proton pump inhibitor maintenance therapy.
 

Author(s): Fumiaki Kawara, Tsuyoshi Fujita, Yoshinori Morita, Atsushi Uda, Atsuhiro Masuda, Masaya Saito, Makoto Ooi, Tsukasa Ishida, Yasuyuki Kondo, Shiei Yoshida, Tatsuya Okuno, Yoshihiko Yano, Masaru Yoshida, Hiromu Kutsumi, Takanobu Hayakumo, Kazuhiko Yamashita, Takeshi Hirano, Midori Hirai, Takeshi Azuma

Journal: World J. Gastroenterol.. 2017 Mar;23(11):2060-2067.

 

To elucidate the factors associated with residual gastroesophageal reflux disease (GERD) symptoms in patients receiving proton pump inhibitor (PPI) maintenance therapy in clinical practice.

Last Updated: 4 Apr 2017

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Characteristics and Outcomes of Laparoscopic Surgery in Patients with Gastroesophageal Reflux and Related Disease: A Single Center Experience.
 

Author(s): Tsutomu Nomura, Katsuhiko Iwakiri, Takeshi Matsutani, Nobutoshi Hagiwara, Itsuo Fujita, Yoshiharu Nakamura, Yoshikazu Kanazawa, Hiroshi Makino, Noriyuki Kawami, Masao Miyashita, Eiji Uchida

Journal: J Nippon Med Sch. 2017 ;84(1):25-31.

 

Laparoscopic anti-reflux surgery (LARS) is generally the treatment of choice for patients with gastroesophageal reflux disease (GERD). This report describes our experiences in performing LARS on patients with GERD, and focuses retrospectively on the pathophysiology of individual patients ...

Last Updated: 23 Mar 2017

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Risk of acute myocardial infarction in patients with gastroesophageal reflux disease: A nationwide population-based study.
 

Author(s): Wei-Yi Lei, Jen-Hung Wang, Shu-Hui Wen, Chih-Hsun Yi, Jui-Sheng Hung, Tso-Tsai Liu, William C Orr, Chien-Lin Chen

Journal:

 

Gastroesophageal reflux disease (GERD) is a common disease which can cause troublesome symptoms and affect quality of life. In addition to esophageal complications, GERD may also be a risk factor for extra-esophageal complications. Both GERD and coronary artery disease (CAD) can cause ...

Last Updated: 20 Mar 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Gastroesophageal reflux disease" returned 120 free, full-text review articles on human participants. First 3 results:

Mucosal Protective Compounds in the Treatment of Gastroesophageal Reflux Disease. A Position Paper Based on Evidence of the Romanian Society of Neurogastroenterology.
 

Author(s): Teodora Surdea-Blaga, Ion Băncilă, Daniela Dobru, Vasile Drug, Ovidiu Frățilă, Adrian Goldiș, Simona M Grad, Crina Mureșan, Laurențiu Nedelcu, Paul J Porr, Ioan Sporea, Dan L Dumitrascu

Journal: J Gastrointestin Liver Dis. 2016 Dec;25(4):537-546.

 

Gastroesophageal reflux disease (GERD) therapy is challenging and suppression of acid secretion or prokinetics do not cure all cases. Some drugs with protective action on the esophageal mucosa have been used alternatively or in association with proton pump inhibitors (PPIs) and/or ...

Last Updated: 16 Dec 2016

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Breathing training on lower esophageal sphincter as a complementary treatment of gastroesophageal reflux disease (GERD): a systematic review.
 

Author(s): M Casale, L Sabatino, A Moffa, F Capuano, V Luccarelli, M Vitali, M Ribolsi, M Cicala, F Salvinelli

Journal: Eur Rev Med Pharmacol Sci. 2016 Nov;20(21):4547-4552.

 

Gastroesophageal reflux disease (GERD) represents one of the most common gastrointestinal disorders, but is still a challenge to cure. Proton pump inhibitors (PPIs) are currently the GERD's standard treatment, although not successful in all patients; some concerns have been raised ...

Last Updated: 22 Nov 2016

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Contribution of immunomodulators to gastroesophageal reflux disease and its complications: stromal cells, interleukin 4, and adiponectin.
 

Author(s): Jing Li, Xiaoxin Luke Chen, Anisa Shaker, Tadayuki Oshima, Jing Shan, Hiroto Miwa, Cheng Feng, Jun Zhang

Journal: Ann. N. Y. Acad. Sci.. 2016 Sep;1380(1):183-194.

 

Gastroesophageal reflux disease (GERD) has become the most commonly seen gastrointestinal disorder in outpatient clinics. In the United States, around 20% of the general population experience heartburn on a weekly basis. Although clinical complaints can be mild or moderate, patients ...

Last Updated: 21 Jul 2016

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Symptom Assessment for Patients With Gastro-esophageal Reflux Disease Receiving Helicobacter Pylori Eradication
 

Status: Not yet recruiting

Condition Summary: Gastroesophageal Reflux Disease

 

Last Updated: 17 Oct 2016

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Impact of Head of Bed Elevation in Symptoms of Patients With Gastroesophageal Reflux Disease
 

Status: Recruiting

Condition Summary: Gastroesophageal Reflux Disease

 

Last Updated: 25 Oct 2016

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Outcomes After Medical and Surgical Treatment of Gastroesophageal Reflux Disease
 

Status: Recruiting

Condition Summary: Gastroesophageal Reflux Disease

 

Last Updated: 13 Jul 2017

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