Gastrointestinal Stromal Tumors

Common Name(s)

Gastrointestinal Stromal Tumors, GIST

Gastrointestinal stromal tumors are a type of soft tissue sarcoma (tumor) that usually begins in cells in the wall of the stomach, intestines, or rectum. These tumors may be noncancerous or cancerous. They can affect adults, adolescents, or children.  It is estimated that around 5,000 new cases of gastrointestinal stromal tumors are diagnosed in the United States each year.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Gastrointestinal Stromal Tumors" for support, advocacy or research.

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GIST Support International

GIST Support International provides support and education for those interested in GIST. This is achieved through a comprehensive and up to date website as well as on line communication via a listserve and facebook. GSI also hosts a once a year patient educaion meeting presented by top GIST experts.

Last Updated: 19 Feb 2013

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Life Raft Group

The Life Raft Group has a simple focus: to cure a form of cancer — GIST (gastrointestinal stromal tumors) – and to help those living with it until then. The mission of the Life Raft Group is to ensure the survival of GIST patients through a comprehensive approach connecting individual patients’ needs, the worldwide community of GIST advocates and the global health and research environment. To do this, we focus on three key areas: research, advocacy and patient support & education.

Last Updated: 28 Mar 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Gastrointestinal Stromal Tumors" for support, advocacy or research.

Logo
GIST Support International

GIST Support International provides support and education for those interested in GIST. This is achieved through a comprehensive and up to date website as well as on line communication via a listserve and facebook. GSI also hosts a once a year patient educaion meeting presented by top GIST experts.

http://www.gistsupport.org

Last Updated: 19 Feb 2013

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Life Raft Group

The Life Raft Group has a simple focus: to cure a form of cancer — GIST (gastrointestinal stromal tumors) – and to help those living with it until then. The mission of the Life Raft Group is to ensure the survival of GIST patients through a comprehensive approach connecting individual patients’ needs, the worldwide community of GIST advocates and the global health and research environment. To do this, we focus on three key areas: research, advocacy and patient support & education.

http://www.liferaftgroup.org

Last Updated: 28 Mar 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Gastrointestinal Stromal Tumors" returned 528 free, full-text research articles on human participants. First 3 results:

Inhibition of stromal-interacting molecule 1-mediated store-operated Ca entry as a novel strategy for the treatment of acquired imatinib-resistant gastrointestinal stromal tumors.
 

Author(s): Ziyi Yang, Lijia Pan, Shilei Liu, Fengnan Li, Wenjie Lv, Yijun Shu, Ping Dong

Journal: Cancer Sci.. 2018 Sep;109(9):2792-2800.

 

Imatinib has revolutionized the treatment of gastrointestinal stromal tumors (GIST); however, primary and secondary resistance to imatinib is still a major cause of treatment failure. Multiple mechanisms are involved in this progression. In the present study, we reported a novel mechanism ...

Last Updated: 31 Dec 1969

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Gastrointestinal stromal tumors: Fibrinogen levels are associated with prognosis of patients as blood-based biomarker.
 

Author(s): Jing Lu, Shuangjiang Chen, Xuqi Li, Guanglin Qiu, Shicai He, Haijiang Wang, Libo Zhou, Yaheng Jing, Xiangming Che, Lin Fan

Journal: Medicine (Baltimore). 2018 Apr;97(17):e0568.

 

Improved prediction of prognosis for primary gastrointestinal stromal tumors (GISTs) after curative resection is an important goal in clinical practice. Coagulation factor of fibrinogen may inform prognosis of tumor patients as blood-based biomarker. Here, we aimed to analyze the ...

Last Updated: 31 Dec 1969

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F-18 FDG PET, CT, and MRI for detecting the malignant potential in patients with gastrointestinal stromal tumors: A protocol for a network meta-analysis of diagnostic test accuracy.
 

Author(s): Kongyuan Wei, Bei Pan, Huan Yang, Cuncun Lu, Long Ge, Nong Cao

Journal: Medicine (Baltimore). 2018 Apr;97(16):e0389.

 

Gastrointestinal stromal tumor (GIST) is a rare cancer in gastrointestinal carcinomas and has been widely known as a curable disease among all the digestive tumors. However, early detection of malignant potential in patients with GIST has still been a huge challenge all around the ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Gastrointestinal Stromal Tumors" returned 96 free, full-text review articles on human participants. First 3 results:

Gastrointestinal stromal tumors: A multidisciplinary challenge.
 

Author(s): Juan Manuel Sanchez-Hidalgo, Manuel Duran-Martinez, Rafael Molero-Payan, Sebastian Rufian-Peña, Alvaro Arjona-Sanchez, Angela Casado-Adam, Antonio Cosano-Alvarez, Javier Briceño-Delgado

Journal: World J. Gastroenterol.. 2018 May;24(18):1925-1941.

 

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors located in the alimentary tract. Its usual manifestation is gastrointestinal bleeding. However, small asymptomatic lesions are frequently detected as incidental finding. Characteristically, most GISTs (> ...

Last Updated: 31 Dec 1969

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Long-Term Imatinib Treatment for Patients with Unresectable or Recurrent Gastrointestinal Stromal Tumors.
 

Author(s): Kyoichi Ogata, Akiharu Kimura, Nobuhiro Nakazawa, Masaki Suzuki, Toru Yanoma, Yasunari Ubukata, Kiyohito Iwamatsu, Norimichi Kogure, Mitsuhiro Yanai, Hiroyuki Kuwano

Journal: Digestion. 2018 ;97(1):20-25.

 

Only limited data are available concerning the long-term outcomes of imatinib treatment among Japanese or Asian patients with advanced or recurrent gastrointestinal stromal tumors (GIST). Our multicenter study, which was conducted in northern Kanto, Japan, aimed to assess the efficacy ...

Last Updated: 31 Dec 1969

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Radiotherapy for Gastrointestinal Stromal Tumors.
 

Author(s): Emine Elif Ozkan

Journal: Chin. Med. J.. 2018 Jan;131(2):235-240.

 

Gastrointestinal stromal tumors (GISTs) are rare mesenchymal tumors of the gastrointestinal tract, which frequently cause intraabdominal metastases. The current standard of care is surgery for localized cases, and adjuvant imatinib is recommended for tumors with a high risk of recurrence. ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Serum Dickkopf-4 as a Biomarker for the Diagnosis and Treatment of Gastrointestinal Stromal Tumor
 

Status: Recruiting

Condition Summary: Gastrointestinal Stromal Tumor

 

Last Updated: 11 Oct 2016

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Last Updated: 7 Aug 2017

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Expanded Access to Everolimus, for an Individual Patient With GIST (Gastrointestinal Stromal Tumors)(CTMS#18-0019)
 

Status: Available

Condition Summary: Gastrointestinal Stromal Tumor

 

Last Updated: 2 Apr 2018

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