Grand mal seizures

Common Name(s)

Grand mal seizures, Generalized tonic-clonic seizures

Grand mal seizures, commonly known as Generalized tonic-clonic seizures, are seizures in which the muscles stiffen, rapid and jerky movements occur, and a person loses consciousness. Those who experience grand mal seizures do not remember them. This is the kind of seizure people typically picture when they hear the word “seizure”. They can occur in both children and adults, and last from 1 to 3 minutes.

Grand mal seizures have two phases: the tonic phase and the clonic phase. In the tonic phase a person will lose consciousness and the muscles will tighten, causing the person to fall. In the clonic phase the muscles will continuously flex and relax for about two minutes. Risk factors for grand mal seizures may include a family history of seizures, heavy alcohol use, heavy use of illegal drugs, brain injuries, infections, stroke, and lack of sleep.

The exact cause of grand mal seizures is unknown. Seizures are a result of abnormal electrical activity in the brain. In a grand mal seizure the entire surface of the brain is experiencing abnormal electrical activity. Doctors diagnose seizures by running a test called electroencephalogram (EEG). This test checks the brain for unusual electrical activity. Grand mal seizures generally occur only once. If they occur more than once, anti-seizure medications are used for treatment. Talk with your doctor to decide which treatment plan is best for you. Support groups are also good resources for support and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Grand mal seizures" for support, advocacy or research.

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Epilepsy Foundation - Home Office

The mission of the Epilepsy Foundation is to stop seizures and SUDEP, find a cure and overcome the challenges created by epilepsy through efforts including education, advocacy and research to accelerate ideas into therapies.

Last Updated: 28 Apr 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Grand mal seizures" for support, advocacy or research.

Logo
Epilepsy Foundation - Home Office

The mission of the Epilepsy Foundation is to stop seizures and SUDEP, find a cure and overcome the challenges created by epilepsy through efforts including education, advocacy and research to accelerate ideas into therapies.

http://www.epilepsy.com

Last Updated: 28 Apr 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Grand mal seizures" returned 11 free, full-text research articles on human participants. First 3 results:

Camphor: an herbal medicine causing grand mal seizures.
 

Author(s): Theodore G MacKinney, Kamal Raj Soti, Poojan Shrestha, Buddha Basnyat

Journal:

 

Camphor is usually used in the USA to repel insects, but it is widely used in other countries as an herb. We report the case of a 52-year-old previously healthy Nepali man who ingested approximately 10 g of pure camphor with therapeutic intention. He developed grand mal seizures, ...

Last Updated: 13 Jun 2015

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Single grand mal seizures provoked by altitude?
 

Author(s): Thomas Kuepper, Joseph Classen

Journal: J Travel Med. ;9(2):94-6.

 

Last Updated: 4 Jun 2002

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Reduced excitability of the motor cortex in untreated patients with de novo idiopathic "grand mal" seizures.
 

Author(s): V Delvaux, G Alagona, P Gérard, V De Pasqua, P J Delwaide, A Maertens de Noordhout

Journal: J. Neurol. Neurosurg. Psychiatr.. 2001 Dec;71(6):772-6.

 

Transcranial magnetic stimulation (TMS) was used to investigate motor cortex excitability, intracortical excitatory, and inhibitory pathways in 18 patients having experienced a first "grand mal" seizure within 48 hours of the electrophysiological test. All had normal brain MRI, and ...

Last Updated: 27 Nov 2001

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Grand mal seizures" returned 1 free, full-text review articles on human participants. First 3 results:

Hyponatraemia and Moduretic-grand mal seizures: a review.
 

Author(s): C Johnston, L Webb, J Daley, G S Spathis

Journal: J R Soc Med. 1989 Aug;82(8):479-83.

 

Three cases are presented which emphasize the importance of hyponatraemia as a cause of grand mal seizures. The combination of hydrochlorothiazide and amiloride appears to increase the risk of hyponatraemia. We discuss the aetiology and treatment of hyponatraemia and review the necessity ...

Last Updated: 18 Oct 1989

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Perampanel as Adjunctive Therapy in Pediatrics With Partial Onset Seizures or Primary Generalized Tonic Clonic Seizures
 

Status: Not yet recruiting

Condition Summary: Partial-Onset or Primary Generalized Tonic-Clonic Seizures

 

Last Updated: 17 Oct 2016

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Last Updated: 4 Aug 2017

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