Glanders

Common Name(s)

Glanders

Glanders is an infectious disease caused by the bacterium Burkholderia mallei. Glanders primarily affects horses, but can also be contracted by humans. Glanders is transmitted to people through direct contact with the tissues or bodily fluids of infected animals, as well as through the inhalation of infected aerosols or dust contaminated by infected animals. Those who care for or handle animals, such as veterinarians, horse caretakers, butchers, and slaughterhouse workers are at an increased risk. Symptoms of glanders commonly include fever with chills and sweating, muscle aches, chest pain, muscle tightness, headache, nasal discharge, and light sensitivity.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Glanders" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Glanders" returned 13 free, full-text research articles on human participants. First 3 results:

Recombinant Salmonella Expressing Burkholderia mallei LPS O Antigen Provides Protection in a Murine Model of Melioidosis and Glanders.
 

Author(s): Dina A Moustafa, Jennifer M Scarff, Preston P Garcia, Sara K B Cassidy, Antonio DiGiandomenico, David M Waag, Thomas J Inzana, Joanna B Goldberg

Journal:

 

Burkholderia pseudomallei and Burkholderia mallei are the etiologic agents of melioidosis and glanders, respectively. These bacteria are highly infectious via the respiratory route and can cause severe and often fatal diseases in humans and animals. Both species are considered potential ...

Last Updated: 31 Dec 1969

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Humoral immune responses in a human case of glanders.
 

Author(s): David M Waag, Marilyn J England, David DeShazer

Journal: Clin. Vaccine Immunol.. 2012 May;19(5):814-6.

 

Within 2 months of acquiring glanders, a patient developed 8-, 16-, and 4-fold increases, respectively, in specific IgA, IgG, and IgM serological titers against Burkholderia mallei. Within 14 months of infection, the titers decreased to the baseline. Serum from this patient was also ...

Last Updated: 31 Dec 1969

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Use of a recombinant burkholderia intracellular motility a protein for immunodiagnosis of glanders.
 

Author(s): Subodh Kumar, Praveen Malik, Shailendra Kumar Verma, Vijai Pal, Vandana Gautam, Chiranjay Mukhopadhyay, Ganga Prasad Rai

Journal: Clin. Vaccine Immunol.. 2011 Sep;18(9):1456-61.

 

Glanders, caused by the Gram-negative, nonmotile bacterium Burkholderia mallei, is a contagious and highly fatal disease of equines. During the last decade, the number of glanders outbreaks has increased steadily. The disease also has high zoonotic significance and B. mallei is listed ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Glanders" returned 2 free, full-text review articles on human participants. First 3 results:

Glanders: an overview of infection in humans.
 

Author(s): Kristopher E Van Zandt, Marek T Greer, H Carl Gelhaus

Journal:

 

Glanders is a highly contagious and often fatal zoonotic disease, primarily of solipds. In the developed world, glanders has been eradicated. However, prior use of B. mallei as a biological weapon and its high mortality in inhalation animal studies has affirmed B. mallei as a biodefense ...

Last Updated: 31 Dec 1969

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Glanders: off to the races with Burkholderia mallei.
 

Author(s): Gregory C Whitlock, D Mark Estes, Alfredo G Torres

Journal: FEMS Microbiol. Lett.. 2007 Dec;277(2):115-22.

 

Burkholderia mallei, the etiologic agent of the disease known as glanders, is primarily a disease affecting horses and is transmitted to humans by direct contact with infected animals. The use of B. mallei as a biological weapon has been reported and currently, there is no vaccine ...

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Post-void Bladder Scanning in Acute Cauda Equina Syndrome
 

Status: Not yet recruiting

Condition Summary: Polyradiculopathy

 

Last Updated: 15 Jun 2016

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BLB Study Back or Leg Pain and Bladder Symptoms Study
 

Status: Recruiting

Condition Summary: Cauda Equina Syndrome; Functional Neurological Disorder

 

Last Updated: 14 Nov 2017

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