Glioblastoma

Common Name(s)

Glioblastoma

Glioblastoma is a malignant (cancerous) brain tumor that develops from a specific type of brain cell called an astrocyte. These cells help support and nourish neurons (nerve cells of the brain) and form scar tissue that helps repair brain damage in response to injury. Glioblastomas are often very aggressive and grow into surrounding brain tissue. Signs and symptoms, such as headache, nausea, vomiting and/or drowsiness, may develop when the tumor begins to put excess pressure on the brain. Affected people may also experience other features depending on the size and location of the tumor. In most cases, the exact underlying cause is unknown; however, they can rarely occur in people with certain genetic syndromes such as neurofibromatosis type 1, Turcot syndrome and Li Fraumeni syndrome. There is currently no cure for glioblastoma. Treatment is palliative and may include surgery, radiation therapy and/or chemotherapy.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Glioblastoma" for support, advocacy or research.

Accelerate Brain Cancer Cure

Our Mission: to invest in research aimed at finding the fastest possible route to a cure. We are focused on speeding the pace of research that will lead to new brain tumor therapies and, ultimately, a cure. We take an aggressive, venture funding approach not typically seen in the nonprofit sector. We have an enterprising attitude, we promote scientific collaboration and we're committed to measurable results.

Last Updated: 7 Jan 2013

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National Brain Tumor Society

National Brain Tumor Society is fiercely committed to finding better treatments, and ultimately a cure, for people living with a brain tumor today and anyone who will be diagnosed tomorrow. This means effecting change in the system at all levels. It’s time to build on progress and transform tomorrow, today.

Last Updated: 21 Nov 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Glioblastoma" for support, advocacy or research.

Accelerate Brain Cancer Cure

Our Mission: to invest in research aimed at finding the fastest possible route to a cure. We are focused on speeding the pace of research that will lead to new brain tumor therapies and, ultimately, a cure. We take an aggressive, venture funding approach not typically seen in the nonprofit sector. We have an enterprising attitude, we promote scientific collaboration and we're committed to measurable results.

http://www.abc2.org

Last Updated: 7 Jan 2013

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National Brain Tumor Society

National Brain Tumor Society is fiercely committed to finding better treatments, and ultimately a cure, for people living with a brain tumor today and anyone who will be diagnosed tomorrow. This means effecting change in the system at all levels. It’s time to build on progress and transform tomorrow, today.

http://braintumor.org/

Last Updated: 21 Nov 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Glioblastoma" returned 3963 free, full-text research articles on human participants. First 3 results:

Analysis of copy number loss of the ErbB4 receptor tyrosine kinase in glioblastoma.
 

Author(s): DeAnalisa C Jones, Adriana Scanteianu, Matthew DiStefano, Mehdi Bouhaddou, Marc R Birtwistle

Journal:

 

Current treatments for glioblastoma multiforme (GBM)-an aggressive form of brain cancer-are minimally effective and yield a median survival of 14.6 months and a two-year survival rate of 30%. Given the severity of GBM and the limitations of its treatment, there is a need for the discovery ...

Last Updated: 31 Dec 1969

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Mathematical modeling identifies optimum lapatinib dosing schedules for the treatment of glioblastoma patients.
 

Author(s): Shayna Stein, Rui Zhao, Hiroshi Haeno, Igor Vivanco, Franziska Michor

Journal:

 

Human primary glioblastomas (GBM) often harbor mutations within the epidermal growth factor receptor (EGFR). Treatment of EGFR-mutant GBM cell lines with the EGFR/HER2 tyrosine kinase inhibitor lapatinib can effectively induce cell death in these models. However, EGFR inhibitors have ...

Last Updated: 31 Dec 1969

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Effect of Tumor-Treating Fields Plus Maintenance Temozolomide vs Maintenance Temozolomide Alone on Survival in Patients With Glioblastoma: A Randomized Clinical Trial.
 

Author(s): Roger Stupp, Sophie Taillibert, Andrew Kanner, William Read, David M Steinberg, Benoit Lhermitte, Steven Toms, Ahmed Idbaih, Manmeet S Ahluwalia, Karen Fink, Francesco Di Meco, Frank Lieberman, Jay-Jiguang Zhu, Giuseppe Stragliotto, David D Tran, Steven Brem, Andreas F Hottinger, Eilon D Kirson, Gitit Lavy-Shahaf, Uri Weinberg, Chae-Yong Kim, Sun-Ha Paek, Garth Nicholas, Jordi Burna, Hal Hirte, Michael Weller, Yoram Palti, Monika E Hegi, Zvi Ram

Journal: JAMA. 2017 12;318(23):2306-2316.

 

Tumor-treating fields (TTFields) is an antimitotic treatment modality that interferes with glioblastoma cell division and organelle assembly by delivering low-intensity alternating electric fields to the tumor.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Glioblastoma" returned 308 free, full-text review articles on human participants. First 3 results:

A comparison between oral chemotherapy combined with radiotherapy and radiotherapy for newly diagnosed glioblastoma: A systematic review and meta-analysis.
 

Author(s): Zhuo Wang, Guozi Yang, Yu-Yu Zhang, Yan Yao, Li-Hua Dong

Journal: Medicine (Baltimore). 2017 Nov;96(44):e8444.

 

The prognosis of glioblastoma (GBM), a major subtype of grade IV glioma, is rather poor nowadays. The efficiency of chemotherapy serving as the adjunct to radiotherapy (RT) for treating GBM is still controversial. In this study, we aim to investigate the overall survival (OS) and ...

Last Updated: 31 Dec 1969

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Progressive multifocal exophytic pontine glioblastoma: a case report with literature review.
 

Author(s): Fanfan Chen, Zongyang Li, Chengyin Weng, Peng Li, Lanbo Tu, Lei Chen, Wei Xie, Ling Li

Journal:

 

Multifocal pontine glioblastoma exhibiting an exophytic growth pattern in the cerebello-pontine angle (CPA) is rare. We present a case of a 5-year-old girl with consecutive neurological imaging and other clinical findings indicating progressive multifocal exophytic pontine glioblastoma. ...

Last Updated: 31 Dec 1969

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Diagnostic and Therapeutic Biomarkers in Glioblastoma: Current Status and Future Perspectives.
 

Author(s): Wojciech Szopa, Thomas A Burley, Gabriela Kramer-Marek, Wojciech Kaspera

Journal: Biomed Res Int. 2017 ;2017():8013575.

 

Glioblastoma (GBM) is a primary neuroepithelial tumor of the central nervous system, characterized by an extremely aggressive clinical phenotype. Patients with GBM have a poor prognosis and only 3-5% of them survive for more than 5 years. The current GBM treatment standards include ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

INtraoperative photoDYnamic Therapy of GliOblastoma
 

Status: Recruiting

Condition Summary: Glioblastoma

 

Last Updated: 8 Nov 2017

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INdividualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT)
 

Status: Recruiting

Condition Summary: Glioblastoma

 

Last Updated: 20 Oct 2017

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Last Updated: 27 Oct 2017

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