Glioblastoma

Common Name(s)

Glioblastoma

Glioblastoma is a malignant (cancerous) brain tumor that develops from a specific type of brain cell called an astrocyte. These cells help support and nourish neurons (nerve cells of the brain) and form scar tissue that helps repair brain damage in response to injury. Glioblastomas are often very aggressive and grow into surrounding brain tissue. Signs and symptoms, such as headache, nausea, vomiting and/or drowsiness, may develop when the tumor begins to put excess pressure on the brain. Affected people may also experience other features depending on the size and location of the tumor. In most cases, the exact underlying cause is unknown; however, they can rarely occur in people with certain genetic syndromes such as neurofibromatosis type 1, Turcot syndrome and Li Fraumeni syndrome. There is currently no cure for glioblastoma. Treatment is palliative and may include surgery, radiation therapy and/or chemotherapy.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Glioblastoma" for support, advocacy or research.

Accelerate Brain Cancer Cure

Our Mission: to invest in research aimed at finding the fastest possible route to a cure. We are focused on speeding the pace of research that will lead to new brain tumor therapies and, ultimately, a cure. We take an aggressive, venture funding approach not typically seen in the nonprofit sector. We have an enterprising attitude, we promote scientific collaboration and we're committed to measurable results.

Last Updated: 7 Jan 2013

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National Brain Tumor Society

National Brain Tumor Society is fiercely committed to finding better treatments, and ultimately a cure, for people living with a brain tumor today and anyone who will be diagnosed tomorrow. This means effecting change in the system at all levels. It’s time to build on progress and transform tomorrow, today.

Last Updated: 21 Nov 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Glioblastoma" for support, advocacy or research.

Accelerate Brain Cancer Cure

Our Mission: to invest in research aimed at finding the fastest possible route to a cure. We are focused on speeding the pace of research that will lead to new brain tumor therapies and, ultimately, a cure. We take an aggressive, venture funding approach not typically seen in the nonprofit sector. We have an enterprising attitude, we promote scientific collaboration and we're committed to measurable results.

http://www.abc2.org

Last Updated: 7 Jan 2013

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National Brain Tumor Society

National Brain Tumor Society is fiercely committed to finding better treatments, and ultimately a cure, for people living with a brain tumor today and anyone who will be diagnosed tomorrow. This means effecting change in the system at all levels. It’s time to build on progress and transform tomorrow, today.

http://braintumor.org/

Last Updated: 21 Nov 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Glioblastoma" returned 4129 free, full-text research articles on human participants. First 3 results:

Targeting experimental orthotopic glioblastoma with chitosan-based superparamagnetic iron oxide nanoparticles (CS-DX-SPIONs).
 

Author(s): Maxim Shevtsov, Boris Nikolaev, Yaroslav Marchenko, Ludmila Yakovleva, Nikita Skvortsov, Anton Mazur, Peter Tolstoy, Vyacheslav Ryzhov, Gabriele Multhoff

Journal:

 

Glioblastoma is the most devastating primary brain tumor of the central nervous system in adults. Magnetic nanocarriers may help not only for a targeted delivery of chemotherapeutic agents into the tumor site but also provide contrast enhancing properties for diagnostics using magnetic ...

Last Updated: 31 Dec 1969

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Inhibition of lipopolysaccharide (LPS)-induced neuroinflammatory response by polysaccharide fractions of Khaya grandifoliola (C.D.C.) stem bark, Cryptolepis sanguinolenta (Lindl.) Schltr and Cymbopogon citratus Stapf leaves in raw 264.7 macrophages and U87 glioblastoma cells.
 

Author(s): Francine Kengne Mediesse, Thaddée Boudjeko, Anantharaju Hasitha, Matharasala Gangadhar, Wilfred Fon Mbacham, Perumal Yogeeswari

Journal:

 

Khaya grandifoliola (C.D.C.) stem bark, Cymbopogon citratus (Stapf) and Cryptolepis sanguinolenta (Lindl.) Schltr leaves are used in Cameroonian traditional medicine for the treatment of inflammatory diseases. Several studies have been performed on the biological activities of secondary ...

Last Updated: 31 Dec 1969

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High EMP3 expression might independently predict poor overall survival in glioblastoma and its expression is related to DNA methylation.
 

Author(s): Hongsheng Yue, Qun Xu, Shugang Xie

Journal: Medicine (Baltimore). 2018 Jan;97(1):e9538.

 

In this study, we analyzed the prognostic value of epithelial membrane protein 3 (EMP3) in terms of overall survival (OS) in glioblastoma multiforme (GBM) and the association between its expression and DNA methylation.Bioinformatic analysis was performed by using data from the Cancer ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Glioblastoma" returned 327 free, full-text review articles on human participants. First 3 results:

A comparison between oral chemotherapy combined with radiotherapy and radiotherapy for newly diagnosed glioblastoma: A systematic review and meta-analysis.
 

Author(s): Zhuo Wang, Guozi Yang, Yu-Yu Zhang, Yan Yao, Li-Hua Dong

Journal: Medicine (Baltimore). 2017 Nov;96(44):e8444.

 

The prognosis of glioblastoma (GBM), a major subtype of grade IV glioma, is rather poor nowadays. The efficiency of chemotherapy serving as the adjunct to radiotherapy (RT) for treating GBM is still controversial. In this study, we aim to investigate the overall survival (OS) and ...

Last Updated: 31 Dec 1969

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Tumor treating fields: a novel and effective therapy for glioblastoma: mechanism, efficacy, safety and future perspectives.
 

Author(s): Ping Zhu, Jay-Jiguang Zhu

Journal: Chin Clin Oncol. 2017 Aug;6(4):41.

 

Tumor treating fields (TTF, Optune®), one of the low-intensity alternating electric fields, have been demonstrated to disrupt mitosis and inhibit tumor growth with antimitotic properties in a variety of tumor types. The Food and Drug Administration (FDA) of the United States approved ...

Last Updated: 31 Dec 1969

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Advanced magnetic resonance imaging in glioblastoma: a review.
 

Author(s): Gaurav Shukla, Gregory S Alexander, Spyridon Bakas, Rahul Nikam, Kiran Talekar, Joshua D Palmer, Wenyin Shi

Journal: Chin Clin Oncol. 2017 Aug;6(4):40.

 

Glioblastoma, the most common and most rapidly progressing primary malignant tumor of the central nervous system, continues to portend a dismal prognosis, despite improvements in diagnostic and therapeutic strategies over the last 20 years. The standard of care radiographic characterization ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

INtraoperative photoDYnamic Therapy of GliOblastoma
 

Status: Recruiting

Condition Summary: Glioblastoma

 

Last Updated: 23 Apr 2018

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Last Updated: 18 May 2018

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INdividualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT)
 

Status: Recruiting

Condition Summary: Glioblastoma

 

Last Updated: 26 Feb 2018

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