Glioblastoma

Common Name(s)

Glioblastoma

Glioblastoma is a malignant (cancerous) brain tumor that develops from a specific type of brain cell called an astrocyte. These cells help support and nourish neurons (nerve cells of the brain) and form scar tissue that helps repair brain damage in response to injury. Glioblastomas are often very aggressive and grow into surrounding brain tissue. Signs and symptoms, such as headache, nausea, vomiting and/or drowsiness, may develop when the tumor begins to put excess pressure on the brain. Affected people may also experience other features depending on the size and location of the tumor. In most cases, the exact underlying cause is unknown; however, they can rarely occur in people with certain genetic syndromes such as neurofibromatosis type 1, Turcot syndrome and Li Fraumeni syndrome. There is currently no cure for glioblastoma. Treatment is palliative and may include surgery, radiation therapy and/or chemotherapy.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Glioblastoma" for support, advocacy or research.

Accelerate Brain Cancer Cure

Our Mission: to invest in research aimed at finding the fastest possible route to a cure. We are focused on speeding the pace of research that will lead to new brain tumor therapies and, ultimately, a cure. We take an aggressive, venture funding approach not typically seen in the nonprofit sector. We have an enterprising attitude, we promote scientific collaboration and we're committed to measurable results.

Last Updated: 7 Jan 2013

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National Brain Tumor Society

National Brain Tumor Society is fiercely committed to finding better treatments, and ultimately a cure, for people living with a brain tumor today and anyone who will be diagnosed tomorrow. This means effecting change in the system at all levels. It’s time to build on progress and transform tomorrow, today.

Last Updated: 21 Nov 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Glioblastoma" for support, advocacy or research.

Accelerate Brain Cancer Cure

Our Mission: to invest in research aimed at finding the fastest possible route to a cure. We are focused on speeding the pace of research that will lead to new brain tumor therapies and, ultimately, a cure. We take an aggressive, venture funding approach not typically seen in the nonprofit sector. We have an enterprising attitude, we promote scientific collaboration and we're committed to measurable results.

http://www.abc2.org

Last Updated: 7 Jan 2013

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National Brain Tumor Society

National Brain Tumor Society is fiercely committed to finding better treatments, and ultimately a cure, for people living with a brain tumor today and anyone who will be diagnosed tomorrow. This means effecting change in the system at all levels. It’s time to build on progress and transform tomorrow, today.

http://braintumor.org/

Last Updated: 21 Nov 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Glioblastoma" returned 4278 free, full-text research articles on human participants. First 3 results:

High-dose fotemustine in temozolomide-pretreated glioblastoma multiforme patients: A phase I/II trial.
 

Author(s): Alfredo Marinelli, Giuseppe Lamberti, Luigi Cerbone, Nadia Cordua, Carlo Buonerba, Gianfranco Peluso, Giuseppe Di Lorenzo, Sabino De Placido

Journal: Medicine (Baltimore). 2018 Jul;97(27):e11254.

 

Glioblastoma multiforme (GBM) is a rare and deadly disease, with a reported average incidence rate of 3.19 cases per 100,000 inhabitants. Fotemustine, a third-generation nitrosourea with an alanine phosphor carrier that facilitates cellular penetration, has been extensively investigated ...

Last Updated: 31 Dec 1969

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Recurrent Glioblastoma Treated with Recombinant Poliovirus.
 

Author(s): Annick Desjardins, Matthias Gromeier, James E Herndon, Nike Beaubier, Dani P Bolognesi, Allan H Friedman, Henry S Friedman, Frances McSherry, Andrea M Muscat, Smita Nair, Katherine B Peters, Dina Randazzo, John H Sampson, Gordana Vlahovic, William T Harrison, Roger E McLendon, David Ashley, Darell D Bigner

Journal: N. Engl. J. Med.. 2018 07;379(2):150-161.

 

The prognosis of patients with recurrent World Health Organization (WHO) grade IV malignant glioma is dismal, and there is currently no effective therapy. We conducted a dose-finding and toxicity study in this population of patients, evaluating convection-enhanced, intratumoral delivery ...

Last Updated: 31 Dec 1969

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Raddeanin a Suppresses Glioblastoma Growth by Inducing ROS Generation and Subsequent JNK Activation to Promote Cell Apoptosis.
 

Author(s): Fei Peng, Xiaoxiong Wang, Mengting Shu, Mingfei Yang, Ligang Wang, Zhongrui Ouyang, Chen Shen, Xu Hou, Boyan Zhao, Xinzhuang Wang, Linda Wei Zhang, Yaohua Liu, Shiguang Zhao

Journal: Cell. Physiol. Biochem.. 2018 ;47(3):1108-1121.

 

Raddeanin A (RA), an active pharmacological ingredient from Anemone raddeana Regel, plays an important role in tumor suppression. In this study, we assessed the potentially therapeutic effect of RA on glioblastoma and its underlying mechanisms.

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Glioblastoma" returned 354 free, full-text review articles on human participants. First 3 results:

Glioblastoma quo vadis: Will migration and invasiveness reemerge as therapeutic targets?
 

Author(s): Florence Lefranc, Emilie Le Rhun, Robert Kiss, Michael Weller

Journal: Cancer Treat. Rev.. 2018 Jul;68():145-154.

 

The purpose of the current review is to highlight, on one hand, the fact that the migratory pattern of glioma cells is the major obstacle to combat them with chemotherapy, and on the other one, the new treatment strategies to overcome this obstacle.

Last Updated: 31 Dec 1969

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The hypoxic peri-arteriolar glioma stem cell niche, an integrated concept of five types of niches in human glioblastoma.
 

Author(s): Diana A Aderetti, Vashendriya V V Hira, Remco J Molenaar, Cornelis J F van Noorden

Journal: Biochim. Biophys. Acta. 2018 04;1869(2):346-354.

 

Glioblastoma is the most lethal primary brain tumor and poor survival of glioblastoma patients is attributed to the presence of glioma stem cells (GSCs). These therapy-resistant, quiescent and pluripotent cells reside in GSC niches, which are specific microenvironments that protect ...

Last Updated: 31 Dec 1969

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Natural Bioactive Compounds: Alternative Approach to the Treatment of Glioblastoma Multiforme.
 

Author(s): Vilas Desai, Alok Bhushan

Journal: Biomed Res Int. 2017 ;2017():9363040.

 

Glioblastoma multiforme (GBM) is the most frequent, primary malignant brain tumor prevalent in humans. GBM characteristically exhibits aggressive cell proliferation and rapid invasion of normal brain tissue resulting in poor patient prognosis. The current standard of care of surgical ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 18 May 2018

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INdividualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT)
 

Status: Recruiting

Condition Summary: Glioblastoma

 

Last Updated: 26 Feb 2018

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Last Updated: 3 Apr 2018

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