Glucose 6 Phosphate Dehydrogenase Deficiency

Common Name(s)

Glucose 6 Phosphate Dehydrogenase Deficiency

Glucose 6 phosphate dehydrogenase (G6PD) deficiency is a hereditary condition in which red blood cells break down (hemolysis) when the body is exposed to certain foods, drugs, infections or stress. This condition occurs when a person is missing or doesn't have enough glucose-6-phosphate dehydrogenase, an enzyme which helps red blood cells work properly. G6PD deficiency is more likely to occur in males, particularly African Americans, and those from certain parts of Africa, Asia, and the Mediterranean. This condition is inherited in an X-linked recessive manner and is caused by mutations in the G6PD gene.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Glucose 6 Phosphate Dehydrogenase Deficiency" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Glucose 6 Phosphate Dehydrogenase Deficiency" returned 253 free, full-text research articles on human participants. First 3 results:

Glucose-6-Phosphate Dehydrogenase Deficiency is Associated with Cardiovascular Disease in U.S. Military Centers.
 

Author(s): John E Thomas, Seungho Kang, Charles J Wyatt, Forest S Kim, A David Mangelsdorff, Fred K Weigel

Journal:

 

Glucose-6-phosphate dehydrogenase (G6PD) protects erythrocytes from oxidative stress and hemolysis; G6PD deficiency is the most prevalent enzymopathy. The United States military routinely performs tests to prevent exposing G6PD-deficient personnel to antimalarial drugs that might ...

Last Updated: 31 Dec 1969

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Mutation of glucose-6-phosphate dehydrogenase deficiency in Chinese Han children in eastern Fujian.
 

Author(s): Yao Chen, Wenlong Xiu, Yi Dong, Jing Wang, Hong Zhao, Yueqing Su, Jinfu Zhou, Yinglin Zeng, Hua Li, Jingzhi Wo, Feng Lin, Honghua Zhang, Hanqiang Chen, Changyi Yang, Wenbin Zhu

Journal: Medicine (Baltimore). 2018 Jul;97(30):e11553.

 

We aim to investigate the mutation types of glucose-6-phosphate dehydrogenase (G6PD) deficiency in Chinese Han children in eastern Fujian Province.A total of 904 Chinese Han neonates (male: 733 with positive G6PD deficiency and 28 with weakly positive deficiency; female: 73 with positive ...

Last Updated: 31 Dec 1969

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Prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency among malaria patients in Upper Myanmar.
 

Author(s): Jinyoung Lee, Tae Im Kim, Jung-Mi Kang, Hojong Jun, Hương Giang Lê, Thị Lam Thái, Woon-Mok Sohn, Moe Kyaw Myint, Khin Lin, Tong-Soo Kim, Byoung-Kuk Na

Journal:

 

Glucose-6-phosphate dehydrogenase (G6PD; EC 1.1.1.49) deficiency is one of the most common X-linked recessive hereditary disorders in the world. Primaquine (PQ) has been used for radical cure of P. vivax to prevent relapse. Recently, it is also used to reduce P. falciparum gametocyte ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Glucose 6 Phosphate Dehydrogenase Deficiency" returned 9 free, full-text review articles on human participants. First 3 results:

Use of primaquine and glucose-6-phosphate dehydrogenase deficiency testing: Divergent policies and practices in malaria endemic countries.
 

Author(s): Judith Recht, Elizabeth A Ashley, Nicholas J White

Journal:

 

Primaquine is the only available antimalarial drug that kills dormant liver stages of Plasmodium vivax and Plasmodium ovale malarias and therefore prevents their relapse ('radical cure'). It is also the only generally available antimalarial that rapidly sterilises mature P. falciparum ...

Last Updated: 31 Dec 1969

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Dual Antiplatelet Therapy in Patients with Glucose-6-Phosphate Dehydrogenase Deficiency undergoing PCI with Drug-Eluting Stents.
 

Author(s): Simone Biscaglia, Alessandra Ferri, Rita Pavasini, Gianluca Campo, Roberto Ferrari

Journal: J. Atheroscler. Thromb.. 2015 ;22(5):535-41.

 

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzyme defect, affecting more than 400 million people worldwide. In patients with G6PD deficiency, the use of aspirin is controversial, since past studies have reported a potential risk of haemolysis related ...

Last Updated: 31 Dec 1969

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Glucose-6-phosphate dehydrogenase deficiency in transfusion medicine: the unknown risks.
 

Author(s): R O Francis, J S Jhang, H P Pham, E A Hod, J C Zimring, S L Spitalnik

Journal: Vox Sang.. 2013 Nov;105(4):271-82.

 

The hallmark of glucose-6-phosphate dehydrogenase (G6PD) deficiency is red blood cell (RBC) destruction in response to oxidative stress. Patients requiring RBC transfusions may simultaneously receive oxidative medications or have concurrent infections, both of which can induce haemolysis ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Effects of N-acetyl Cystein (NAC) Supplementation in G6PD Deficient Individuals After Acute Exercise
 

Status: Not yet recruiting

Condition Summary: G6PD Deficiency

 

Last Updated: 2 May 2018

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Assessing a Risk Model for G6PD Deficiency
 

Status: Recruiting

Condition Summary: Malaria, Vivax; G6PD Deficiency

 

Last Updated: 14 Sep 2018

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Safety and Efficacy of Different Regimens of Primaquine on Vivax Malaria Treatment in G6PD Deficient Patients
 

Status: Recruiting

Condition Summary: Vivax Malaria; G6PD Deficiency

 

Last Updated: 25 Jul 2018

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