Glutathione peroxidase deficiency

Common Name(s)

Glutathione peroxidase deficiency

Several documented cases of glutathione peroxidase (GPX1; {138320}) deficiency in association with hemolytic anemia have been reported. However, {8:Paglia (1989)} stated: 'To date, no defects in glutathione peroxidase have been unequivocally incriminated in the pathogenesis of hemolytic syndromes, although several instances of partial deficiency have been reported in patients with anemias of unknown etiology. This association may be coincidental, since there is a broad range of ethnic variation in the erythrocyte enzyme' ({1:Beutler and Matsumoto, 1975}).
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Glutathione peroxidase deficiency" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Glutathione peroxidase deficiency" returned 11 free, full-text research articles on human participants. First 3 results:

Glutathione peroxidase 1 deficiency attenuates concanavalin A-induced hepatic injury by modulation of T-cell activation.
 

Author(s): D H Lee, D J Son, M H Park, D Y Yoon, S B Han, J T Hong

Journal:

 

Concanavalin A (Con A)-induced hepatitis model is well-established experimental T cell-mediated liver disease. Reactive oxygen species (ROS) is associated with T-cell activation and proliferation, but continued ROS exposure induces T-cell hyporesponsiveness. Because glutathione peroxidase ...

Last Updated: 31 Dec 1969

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Impact of glutathione peroxidase-1 deficiency on macrophage foam cell formation and proliferation: implications for atherogenesis.
 

Author(s): Fei Cheng, Michael Torzewski, Adriana Degreif, Heidi Rossmann, Antje Canisius, Karl J Lackner

Journal:

 

Clinical and experimental evidence suggests a protective role for the antioxidant enzyme glutathione peroxidase-1 (GPx-1) in the atherogenic process. GPx-1 deficiency accelerates atherosclerosis and increases lesion cellularity in ApoE(-/-) mice. However, the distribution of GPx-1 ...

Last Updated: 31 Dec 1969

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Glutathione peroxidase-1 deficiency augments proinflammatory cytokine-induced redox signaling and human endothelial cell activation.
 

Author(s): Edith Lubos, Neil J Kelly, Scott R Oldebeken, Jane A Leopold, Ying-Yi Zhang, Joseph Loscalzo, Diane E Handy

Journal: J. Biol. Chem.. 2011 Oct;286(41):35407-17.

 

Glutathione peroxidase-1 (GPx-1) is a crucial antioxidant enzyme, the deficiency of which promotes atherogenesis. Accordingly, we examined the mechanisms by which GPx-1 deficiency enhances endothelial cell activation and inflammation. In human microvascular endothelial cells, we found ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

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The terms "Glutathione peroxidase deficiency" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

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