Gomez Lopez Hernandez syndrome (GLHS) is a rare condition characterized by a triad (3) of common symptoms including a malformation of the back part of the brain (rhombencephalosynapsis or RS), hair loss (alopecia) and nerve pain associated with the trigeminal nerve which affects the face (trigeminal anesthesia). Alopecia and trigeminal nerve pain may be mild and the alopecia tends to be seen on the sides of the head. Other findings may include skull abnormalities, facial differences, short stature, motor delays and low muscle tone. Intellectual impairment is typical in this condition but some reports of normal intelligence have been described. The underlying cause of this condition has not been determined. Facial differences and alopecia may be apparent very early in life and MRI of the brain can help determine the presence or absence of RS. RS can occur as an isolated finding meaning not associated with GLHS or other conditions. If RS is the first finding, other symptoms of GLHS should be sought to aid in diagnosis.