Hairy Cell Leukemia

Common Name(s)

Hairy Cell Leukemia

Hairy cell leukemia is a rare, slow-growing cancer of the blood in which the bone marrow makes too many B cells (lymphocytes), a type of white blood cell that fights infection. The condition is named after these excess B cells which look 'hairy' under a microscope. As the number of leukemia cells increases, fewer healthy white blood cells, red blood cells and platelets are produced. The underlying cause of this condition is unknown. While there is no cure, treatment can lead to remission which can last for years.   
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hairy Cell Leukemia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hairy Cell Leukemia" returned 371 free, full-text research articles on human participants. First 3 results:

Toxoplasmic Encephalitis with Untreated Hairy Cell Leukemia Variant.
 

Author(s): Taichi Ikebe, Hitohiro Sasaki, Hiroyuki Takata, Yasuhiko Miyazaki, Eiichi Ohtsuka, Yoshio Saburi, Masao Ogata, Kuniaki Shirao

Journal: Intern. Med.. ;55(21):3175-3180.

 

Toxoplasmic encephalitis is a rare infectious complication in patients with hematological malignancy except for allogeneic hematopoietic stem cell transplantation (HSCT). We herein report a case of possible toxoplasmic encephalitis with untreated hairy cell leukemia variant. Magnetic ...

Last Updated: 2 Nov 2016

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BRAF inhibition in hairy cell leukemia with low-dose vemurafenib.
 

Author(s): Sascha Dietrich, Andreas Pircher, Volker Endris, Frédéric Peyrade, Clemens-Martin Wendtner, George A Follows, Jennifer Hüllein, Alexander Jethwa, Elena Ellert, Tatjana Walther, Xiyang Liu, Martin J S Dyer, Thomas Elter, Tilman Brummer, Robert Zeiser, Michael Hermann, Michael Herold, Wilko Weichert, Claire Dearden, Torsten Haferlach, Martina Seiffert, Michael Hallek, Christof von Kalle, Anthony D Ho, Anita Gaehler, Mindaugas Andrulis, Michael Steurer, Thorsten Zenz

Journal: Blood. 2016 Jun;127(23):2847-55.

 

The activating mutation of the BRAF serine/threonine protein kinase (BRAF V600E) is the key driver mutation in hairy cell leukemia (HCL), suggesting opportunities for therapeutic targeting. We analyzed the course of 21 HCL patients treated with vemurafenib outside of trials with individual ...

Last Updated: 10 Jun 2016

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Impact of telomere length on survival in classic and variant hairy cell leukemia.
 

Author(s): Evgeny Arons, Hong Zhou, Daniel C Edelman, Allison Gomez, Seth M Steinberg, David Petersen, Yonghong Wang, Paul S Meltzer, Robert J Kreitman

Journal: Leuk. Res.. 2015 Dec;39(12):1360-6.

 

Telomeres, which protect the ends of chromosomes, are shortened in several hematologic malignancies, often with adverse prognostic implications, but their effect on prognosis of classic and variant hairy cell leukemia (HCL and HCLv) has not been reported. HCL/HCLv genomic DNA from ...

Last Updated: 25 Nov 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hairy Cell Leukemia" returned 22 free, full-text review articles on human participants. First 3 results:

Consensus guidelines for the diagnosis and management of patients with classic hairy cell leukemia.
 

Author(s): Michael R Grever, Omar Abdel-Wahab, Leslie A Andritsos, Versha Banerji, Jacqueline Barrientos, James S Blachly, Timothy G Call, Daniel Catovsky, Claire Dearden, Judit Demeter, Monica Else, Francesco Forconi, Alessandro Gozzetti, Anthony D Ho, James B Johnston, Jeffrey Jones, Gunnar Juliusson, Eric Kraut, Robert J Kreitman, Loree Larratt, Francesco Lauria, Gerard Lozanski, Emili Montserrat, Sameer A Parikh, Jae H Park, Aaron Polliack, Graeme R Quest, Kanti R Rai, Farhad Ravandi, Tadeusz Robak, Alan Saven, John F Seymour, Tamar Tadmor, Martin S Tallman, Constantine Tam, Enrico Tiacci, Xavier Troussard, Clive S Zent, Thorsten Zenz, Pier Luigi Zinzani, Brunangelo Falini

Journal: Blood. 2017 Feb;129(5):553-560.

 

Hairy cell leukemia is an uncommon hematologic malignancy characterized by pancytopenia and marked susceptibility to infection. Tremendous progress in the management of patients with this disease has resulted in high response rates and improved survival, yet relapse and an appropriate ...

Last Updated: 1 Dec 2016

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BRAF V600E mutation in hairy cell leukemia: from bench to bedside.
 

Author(s): Brunangelo Falini, Maria Paola Martelli, Enrico Tiacci

Journal: Blood. 2016 Oct;128(15):1918-1927.

 

Hairy cell leukemia (HCL) is a distinct clinicopathological entity whose underlying genetic lesion has remained a mystery for over half a century. The BRAF V600E mutation is now recognized as the causal genetic event of HCL because it is somatic, present in the entire tumor clone, ...

Last Updated: 24 Aug 2016

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CD5 positive hairy cell leukemia: A rare case report with brief review of literature.
 

Author(s): Dharmendra Jain, Pranav Dorwal, Smeeta Gajendra, Amit Pande, Simmi Mehra, Ritesh Sachdev

Journal: Cytometry B Clin Cytom. 2016 Sep;90(5):467-72.

 

The aberrant expression of CD5 in both HCL and HCL-v is a very rare event. Although a number of CD5 positive HCL and HCL-v cases have been reported, but these are far and few in between. We aimed to review the reported cases of CD5 positive HCL and its variant.

Last Updated: 17 Sep 2016

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Therapy Optimisation for the Treatment of Hairy Cell Leukemia
 

Status: Recruiting

Condition Summary: Hairy Cell Leukemia

 

Last Updated: 25 Oct 2016

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Cladribine With Simultaneous or Delayed Rituximab to Treat Hairy Cell Leukemia
 

Status: Recruiting

Condition Summary: Hairy Cell Leukemia

 

Last Updated: 18 Oct 2017

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