Langerhans cell histiocytosis

Common Name(s)

Langerhans cell histiocytosis, Eosinophilic Granuloma, Hand-Schuller-Christian disease

Langerhans cell histiocytosis (LCH) is a disorder that primarily affects children, but is also found in adults of all ages. People with LCH produce too many Langerhans cells or histiocytes, a form of white blood cell found in healthy people that is supposed to protect the body from infection. In people with LCH, these cells multiply excessively and build up in certain areas of the body, causing tumors called granulomas to form. The symptoms vary among affected individuals, and the cause of LCH is unknown. In most cases, this condition is not life-threatening. Some people do experience life-long problems associated with LCH.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Langerhans cell histiocytosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Langerhans cell histiocytosis" returned 321 free, full-text research articles on human participants. First 3 results:

Congenital Langerhans cell histiocytosis: a good prognosis disease?
 

Author(s): Ana Paula Frade, Mariana Marteleto Godinho, Anna Beatriz Willemes Batalha, Ana Paula Silva Bueno

Journal: An Bras Dermatol. 2017 ;92(5 Suppl 1):40-42.

 

Langerhans cell histiocytosis is rare and more frequent in children. The skin is affected in 50% of the cases and is the only site in 10%. Its course varies from self-limited and localized forms to severe multisystemic forms. Congenital cases are usually exclusively cutaneous and ...

Last Updated: 31 Dec 1969

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Langerhans' cell histiocytosis with neurological injuries diagnosed from a single cutaneous lesion.
 

Author(s): Andréa Bauer Bannach, Maria Teresa Fernandes Castilho Garcia, Deusita Fernandes Gandia Soares, Antônio Luiz de Arruda Mattos, Tomás Zecchini Barrese, Marilda Aparecida Milanez Morgado de Abreu

Journal: An Bras Dermatol. ;92(4):540-542.

 

Histiocytoses are rare diseases caused by the proliferation of histiocytes. The pathogenesis remains unknown and the highest incidence occurs in pediatric patients. The clinical presentations can be varied, in multiple organs and systems, and the skin lesions are not always present. ...

Last Updated: 31 Dec 1969

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New somatic BRAF splicing mutation in Langerhans cell histiocytosis.
 

Author(s): Sébastien Héritier, Zofia Hélias-Rodzewicz, Rikhia Chakraborty, Amel G Sengal, Christine Bellanné-Chantelot, Caroline Thomas, Anne Moreau, Sylvie Fraitag, Carl E Allen, Jean Donadieu, Jean-François Emile

Journal:

 

Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasia with constitutive activation of the MAPKinase RAS-RAF-MEK-ERK cell signaling pathway. We analyzed 9 LCH cases without BRAF and MAP2K1 mutations by whole exome sequencing. We identified a new somatic BRAF splicing ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Langerhans cell histiocytosis" returned 49 free, full-text review articles on human participants. First 3 results:

Langerhans cell histiocytosis of the thyroid complicated by papillary thyroid carcinoma: A case report and brief literature review.
 

Author(s): Xin Wu, Shi Chen, Li-Yang Zhang, Ya-Ping Luo, Ying Jiang, Rui-E Feng

Journal: Medicine (Baltimore). 2017 Sep;96(35):e7954.

 

Langerhans cell histiocytosis (LCH) involves mainly the skin and bone and rarely the thyroid. Meanwhile, papillary thyroid carcinoma (PTC) is the most common subtype of thyroid cancer. Both LCH and PTC could make the thyroid enlarged and hypermetabolic. The coincidence of these 2 ...

Last Updated: 31 Dec 1969

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Langerhans Cell Histiocytosis and Langerhans Cell Sarcoma: Current Understanding and Differential Diagnosis.
 

Author(s): Hirokazu Nakamine, Mitsunori Yamakawa, Tadashi Yoshino, Takaya Fukumoto, Yasunori Enomoto, Itaru Matsumura

Journal: J Clin Exp Hematop. 2016 ;56(2):109-118.

 

Langerhans cell (LC) histiocytosis (LCH) and LC sarcoma (LCS) are proliferative processes consisting of cells having morphologic and phenotypic features of Langerhans cells (LCs), although the latter may have lost some of these features. Because neoplastic nature of LCH as well as ...

Last Updated: 31 Dec 1969

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Langerhans cell histiocytosis in adults: a case report and review of the literature.
 

Author(s): Cuihong Lian, Yuan Lu, Siyuan Shen

Journal: Oncotarget. 2016 Apr;7(14):18678-83.

 

Langerhans cell histiocytosis (LCH) is a proliferative disease of histiocyte-like cells that generally affects children. Immunohistochemistry is essential to obtain the correct diagnosis, and treatment protocols are controversial.

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Phase II Study of Clofarabine in Patients With Recurrent or Refractory Langerhans Cell Histiocytosis
 

Status: Recruiting

Condition Summary: Langerhans Cell Histiocytosis

 

Last Updated: 25 Apr 2017

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Last Updated: 17 Nov 2016

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Vinblastine/Prednisone Versus Single Therapy With Cytarabine for Langerhans Cell Histiocytosis (LCH)
 

Status: Recruiting

Condition Summary: Langerhans Cell Histiocytosis

 

Last Updated: 15 Nov 2017

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