Heart Defects

Common Name(s)

Heart Defects

Congenital heart defects are problems with the heart’s structure that are present at birth. These problems may affect the overall shape of the heart, the heart’s valves, and the arteries and veins that carry blood to the heart or the body. Congenital heart defects affect 8 out of every 1,000 newborns, and more than 35,000 babies in the United States are born with a heart defect. Although the exact causes are unknown, heart defects may be linked to heredity factors, other genetic disorders (i.e. Down syndrome), and smoking during pregnancy. Severity ranges from defects with no symptoms to life-threatening defects. Many heart defects are easily fixed, although the more serious ones require attention throughout a person’s lifetime. Diagnosis may include a physical examination, X-rays, or various heart function tests. Defects can be treated with medication, surgery or through minimally invasive catheter procedures. In such procedures, a needle is used to insert a catheter into a vein or artery to repair the defect.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Heart Defects" for support, advocacy or research.

Kids with Heart National Association for Children's Heart Disorders

Our organization was formed in 1985 with the main mission of providing support, information, resources, and education for the families of the children living with congenital heart defects and to promote public awareness of the issues that these families live with on a day to day basis.

Last Updated: 4 May 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Heart Defects" for support, advocacy or research.

Kids with Heart National Association for Children's Heart Disorders

Our organization was formed in 1985 with the main mission of providing support, information, resources, and education for the families of the children living with congenital heart defects and to promote public awareness of the issues that these families live with on a day to day basis.

http://www.kidswithheart.org

Last Updated: 4 May 2015

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General Support Organizations

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General Resources

 
 
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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Heart Defects" returned 465 free, full-text research articles on human participants. First 3 results:

Epidemiology and major subtypes of congenital heart defects in Hunan Province, China.
 

Author(s): Donghua Xie, Junqun Fang, Zhiyu Liu, Hua Wang, Tubao Yang, Zhenqiu Sun, Aihua Wang, Lili Xiong

Journal: Medicine (Baltimore). 2018 Aug;97(31):e11770.

 

Congenital heart defects (CHDs) are the most common birth defects (BDs) and account for nearly one-third of all BDs. The aim of this article was to investigate the epidemiology and major subtypes of CHDs in Hunan Province, China in the last 5 years.CHD surveillance data from 2012 ...

Last Updated: 31 Dec 1969

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Rare copy number variants analysis identifies novel candidate genes in heterotaxy syndrome patients with congenital heart defects.
 

Author(s): Chunjie Liu, Ruixue Cao, Yuejuan Xu, Tingting Li, Fen Li, Sun Chen, Rang Xu, Kun Sun

Journal:

 

Heterotaxy (Htx) syndrome comprises a class of congenital disorders resulting from malformations in left-right body patterning. Approximately 90% of patients with heterotaxy have serious congenital heart diseases; as a result, the survival rate and outcomes of Htx patients are not ...

Last Updated: 31 Dec 1969

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Decreased tissue oxygenation in newborns with congenital heart defects: a case-control study.
 

Author(s): Petja Fister, Domen Robek, Darja Paro-Panjan, Uroš Mazić, Helena Lenasi

Journal: Croat. Med. J.. 2018 Apr;59(2):71-78.

 

To compare regional tissue oxygenation (rSO2) in the brain, intestine, and kidney between newborns with and without congenital heart defects (CHD).

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Heart Defects" returned 52 free, full-text review articles on human participants. First 3 results:

Comparison of transcatheter closure, mini-invasive closure, and open-heart surgical repair for treatment of perimembranous ventricular septal defects in children: A PRISMA-compliant network meta-analysis of randomized and observational studies.
 

Author(s): Kang Yi, Tao You, Zhao-Hong Ding, Xiao-Dong Hou, Xing-Guang Liu, Xin-Kuan Wang, Jin-Hui Tian

Journal: Medicine (Baltimore). 2018 Oct;97(40):e12583.

 

Our study was aimed to comprehensively compare the relative efficacy, safety, and the cost of transcatheter closure, mini-invasive closure, and open-heart surgical repair to treat perimembranous ventricular septal defects (pmVSDs) in children using network meta-analysis method.

Last Updated: 31 Dec 1969

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MTHFR A1298C polymorphisms reduce the risk of congenital heart defects: a meta-analysis from 16 case-control studies.
 

Author(s): Di Yu, Zhulun Zhuang, Zhongyuan Wen, Xiaodong Zang, Xuming Mo

Journal:

 

Methylenetetrahydrofolate reductase (MTHFR) plays a crucial role in the hyperhomocysteinemia, which is a risk factor related to the occurrence of congenital heart defect (CHD). However, the association between MTHFR polymorphism and CHD has been inconclusive.

Last Updated: 31 Dec 1969

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Congenital heart defects in IVF/ICSI pregnancy: systematic review and meta-analysis.
 

Author(s): V Giorgione, F Parazzini, V Fesslova, S Cipriani, M Candiani, A Inversetti, C Sigismondi, F Tiberio, P Cavoretto

Journal: Ultrasound Obstet Gynecol. 2018 01;51(1):33-42.

 

There is no consensus in current practice guidelines on whether conception by in-vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) techniques is an indication for performing a fetal echocardiogram. The aim of the study was to assess whether congenital heart defects ...

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Neurodevelopment in Infants With Complex Congenital Heart Defects
 

Status: Recruiting

Condition Summary: Complex Congenital Heart Defect

 

Last Updated: 18 May 2018

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Impact of Psychoeducation in Quality of Life of Parents With Children With Congenital Heart Defects
 

Status: Not yet recruiting

Condition Summary: Congenital Heart Defects

 

Last Updated: 29 Oct 2018

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Electro-acupuncture (EA) in Children Undergoing Procedures for Congenital Heart Defects.
 

Status: Recruiting

Condition Summary: Congenital Heart Defect

 

Last Updated: 15 Nov 2017

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