Heart Defects

Common Name(s)

Heart Defects

Congenital heart defects are problems with the heart’s structure that are present at birth. These problems may affect the overall shape of the heart, the heart’s valves, and the arteries and veins that carry blood to the heart or the body. Congenital heart defects affect 8 out of every 1,000 newborns, and more than 35,000 babies in the United States are born with a heart defect. Although the exact causes are unknown, heart defects may be linked to heredity factors, other genetic disorders (i.e. Down syndrome), and smoking during pregnancy. Severity ranges from defects with no symptoms to life-threatening defects. Many heart defects are easily fixed, although the more serious ones require attention throughout a person’s lifetime. Diagnosis may include a physical examination, X-rays, or various heart function tests. Defects can be treated with medication, surgery or through minimally invasive catheter procedures. In such procedures, a needle is used to insert a catheter into a vein or artery to repair the defect.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Heart Defects" for support, advocacy or research.

Kids with Heart National Association for Children's Heart Disorders

Our organization was formed in 1985 with the main mission of providing support, information, resources, and education for the families of the children living with congenital heart defects and to promote public awareness of the issues that these families live with on a day to day basis.

Last Updated: 4 May 2015

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Heart Defects" for support, advocacy or research.

Kids with Heart National Association for Children's Heart Disorders

Our organization was formed in 1985 with the main mission of providing support, information, resources, and education for the families of the children living with congenital heart defects and to promote public awareness of the issues that these families live with on a day to day basis.

http://www.kidswithheart.org

Last Updated: 4 May 2015

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

General Resources

 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Heart Defects" returned 409 free, full-text research articles on human participants. First 3 results:

A Meta-Analysis of the Relationship Between Maternal Folic Acid Supplementation and the Risk of Congenital Heart Defects.
 

Author(s): Aiping Xu, Xian Cao, Ying Lu, Haibo Li, Qingwen Zhu, Xiaobo Chen, Hongru Jiang, Xiaoqin Li

Journal: Int Heart J. 2016 Dec;57(6):725-728.

 

Controversial opinions exist with respect to the relationship between maternal folic acid (FA) supplementation and birth prevalence of congenital heart defects (CHDs).Eligible articles were retrieved by searching databases, including PubMed, Cochrane library, EMBASE, CNKI, and WanFang ...

Last Updated: 10 Nov 2016

Go To URL
Identification of altered pathways in Down syndrome-associated congenital heart defects using an individualized pathway aberrance score.
 

Author(s): Y Q Chen, T Li, W Y Guo, F J Su, Y X Zhang

Journal:

 

The aim of this study was to identify disrupted pathways related to Down syndrome (DS), and DS-associated congenital heart defects (DS-CHD). The gene expression profile and pathway data of 10 human DS patients and 5 control samples in E-GEOD-1789 were recruited and analyzed by the ...

Last Updated: 13 May 2016

Go To URL
Effects of the Trendelenburg Position and Positive End-Expiratory Pressure on the Internal Jugular Vein Cross-Sectional Area in Children With Simple Congenital Heart Defects.
 

Author(s): Hee Yeong Kim, Jae Moon Choi, Yong-Hun Lee, Sukyung Lee, Hwanhee Yoo, Mijeung Gwak

Journal: Medicine (Baltimore). 2016 May;95(18):e3525.

 

Catheterization of the internal jugular vein (IJV) remains difficult in pediatric populations. Increasing the cross-sectional area (CSA) of the IJV facilitates cannulation and decreases complications. We aimed to evaluate the Trendelenburg position and the levels of positive end-expiratory ...

Last Updated: 6 May 2016

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Heart Defects" returned 44 free, full-text review articles on human participants. First 3 results:

Xenopus as a model organism for birth defects-Congenital heart disease and heterotaxy.
 

Author(s): Anna R Duncan, Mustafa K Khokha

Journal: Semin. Cell Dev. Biol.. 2016 Mar;51():73-9.

 

Congenital heart disease is the leading cause of birth defects, affecting 9 out of 1000 newborns each year. A particularly severe form of congenital heart disease is heterotaxy, a disorder of left-right development. Despite aggressive surgical management, patients with heterotaxy ...

Last Updated: 18 Mar 2016

Go To URL
Assessment of right ventricular systolic function by echocardiography after surgical repair of congenital heart defects.
 

Author(s): Diala Khraiche, Nidhal Ben Moussa

Journal: Arch Cardiovasc Dis. 2016 Feb;109(2):113-9.

 

Postoperative impairment of right ventricular (RV) systolic function can appear after surgical repair of complex congenital heart defects, such as tetralogy of Fallot; it is caused by chronic volume and/or pressure overload due to pulmonary regurgitation and/or stenosis. RV dysfunction ...

Last Updated: 26 Feb 2016

Go To URL
Eligibility and Disqualification Recommendations for Competitive Athletes With Cardiovascular Abnormalities: Task Force 9: Arrhythmias and Conduction Defects: A Scientific Statement From the American Heart Association and American College of Cardiology.
 

Author(s): Douglas P Zipes, Mark S Link, Michael J Ackerman, Richard J Kovacs, Robert J Myerburg, N A Mark Estes,

Journal: Circulation. 2015 Dec;132(22):e315-25.

 

Last Updated: 1 Dec 2015

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Molecular Genetics of Heterotaxy and Related Congenital Heart Defects
 

Status: Recruiting

Condition Summary: Heterotaxy Syndrome; Congenital Heart Defects

 

Last Updated: 7 Mar 2017

Go to URL
Exclusive Human Milk Feeding in Infants With Single Ventricle Physiology
 

Status: Recruiting

Condition Summary: Congenital Heart Defect

 

Last Updated: 22 Aug 2016

Go to URL
An Evaluation of Routine Developmental Follow-Up in Infants and Children With Congenital Heart Disease
 

Status: Recruiting

Condition Summary: Congenital Heart Defects

 

Last Updated: 20 Jul 2016

Go to URL