Hemangioma

Common Name(s)

Hemangioma

A hemangioma is a noncancerous clumping of blood vessels found on the skin or internal organs, most commonly the liver. Hemangiomas are often present at birth or develop in the first few months of life. Skin hemangiomas are quite common, mostly found on the face and neck. Liver hemangiomas rarely cause symptoms. Cavernous hemangiomas most commonly form on the brain or spinal cord and have a different outcome than the other types of hemangiomas. The cause of the clumping of the blood vessels is not well understood.

Skin hemangiomas form on the surface of the skin or in the fatty layer just underneath. It may at first appear as a flat birth mark, but will become a raised red rubbery or spongy lump over the first year. Most will stop growing at this point and after some time will begin to go away. Most skin hemangiomas disappear by age 10, though a faint discoloration may remain. Hemangiomas may affect the vision if they are on the eyelid.

Liver hemangiomas can form within the organ or on its surface. Liver hemangiomas may be estrogen sensitive, meaning they may grow if a woman is given estrogen supplements during menopause. Hemangiomas may also form on the kidneys, colon, and lungs. A hemangioma on any of these organs rarely causes problems unless it grows too large or multiple hemangiomas form. Symptoms may then include nausea, vomiting, abdominal pain, and loss of appetite. Occasionally they interfere with breathing. However, they usually go unnoticed unless picked up by an imaging study (MRI) being done for another reason.

Diagnosis is made by physical exam and imaging studies. Many hemangiomas will go away without treatment. If causing problems, treatment may include laser procedures, steroid injections, medication or surgical removal. If you or your child has been diagnosed with hemangioma, talk to your doctor about the most current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hemangioma" for support, advocacy or research.

VHL Alliance

VHLA is dedicated to research, education, and support to improve awareness, diagnosis, treatment, and quality of life for those affected by VHL.

Last Updated: 5 Jan 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hemangioma" for support, advocacy or research.

VHL Alliance

VHLA is dedicated to research, education, and support to improve awareness, diagnosis, treatment, and quality of life for those affected by VHL.

http://www.vhl.org

Last Updated: 5 Jan 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hemangioma" returned 777 free, full-text research articles on human participants. First 3 results:

Expression profile of circular RNAs in infantile hemangioma detected by RNA-Seq.
 

Author(s): Jun Li, Qian Li, Ling Chen, Yanli Gao, Jingyun Li

Journal: Medicine (Baltimore). 2018 May;97(21):e10882.

 

Circular RNAs (circRNAs) have emerged as a novel class of widespread non-coding RNAs, and they play crucial roles in various biological processes. However, the characterization and function of circRNAs in infantile hemangioma (IH) remain elusive.

Last Updated: 31 Dec 1969

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Treatment of hemangioma of the spleen by preoperative partial splenic embolization plus laparoscopic partial splenectomy: A case report.
 

Author(s): Lu Zheng, Changlin Deng, Jing Li, Liang Wang, Nan You, Ke Wu, Weiwei Wang

Journal: Medicine (Baltimore). 2018 Apr;97(17):e0498.

 

Complete loss of splenic function increases infection and cardiovascular disease risks, so there is growing emphasis on spleen-preserving treatments, such as laproscopic partial splenectomy (LPS). However, LPS carries higher risk for hemorrhage. Sequential splenic embolization can ...

Last Updated: 31 Dec 1969

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Pigment epithelium-derived factor/vascular endothelial growth factor ratio plays a crucial role in the spontaneous regression of infant hemangioma and in the therapeutic effect of propranolol.
 

Author(s): Liuqing Zhu, Jinye Xie, Zhenyin Liu, Zhijian Huang, Mao Huang, Haofan Yin, Weiwei Qi, Zhonghan Yang, Ti Zhou, Guoquan Gao, Jing Zhang, Xia Yang

Journal: Cancer Sci.. 2018 Jun;109(6):1981-1994.

 

Infantile hemangioma (IH) is a benign tumor that is formed by aberrant angiogenesis and that undergoes spontaneous regression over time. Propranolol, the first-line therapy for IH, inhibits angiogenesis by downregulating activation of the vascular endothelial growth factor (VEGF) ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hemangioma" returned 99 free, full-text review articles on human participants. First 3 results:

A rare case of important and recurrent abnormal uterine bleeding in a post partum woman caused by cavernous hemangioma: a case report and review of literature.
 

Author(s): Kacou Edele Aka, Gninlgninrin Apollinaire Horo, Minata Fomba, Salif Kouyate, Abdoul Koffi Koffi, Seni Konan, Mohamed Fanny, Benjamin Effi, Mamourou Kone

Journal:

 

The cavernous hemangioma is a rare benign vascular tumor. About 50 cases of this disease were found in the literature over the last century and only 9 cases of cavernous hemangioma on the pregnant uterus were published it comes into cavernous or capillary form. The symptomatology ...

Last Updated: 31 Dec 1969

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A primary cavernous hemangioma of the thyroid gland: A case report and literature review.
 

Author(s): Jie Miao, Shubo Chen, Yongcai Li, Lin Fu, Hui Li

Journal: Medicine (Baltimore). 2017 Dec;96(49):e8651.

 

Thyroid hemangioma is benign and associated with fine-needle aspiration (FNA) biopsy or trauma in most cases. Its differential diagnosis is very difficult.

Last Updated: 31 Dec 1969

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Giant liver hemangioma with adult Kasabach-Merritt syndrome: Case report and literature review.
 

Author(s): Xiaolei Liu, Zhiying Yang, Haidong Tan, Li Xu, Yongliang Sun, Shuang Si, Liguo Liu, Wenying Zhou, Jia Huang

Journal: Medicine (Baltimore). 2017 Aug;96(31):e7688.

 

Adult Kasabach-Merritt syndrome associated with giant liver hemangioma is rare; to date, most reports have been single-case reports, and no multi-case reports or literature reviews are available.

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Clinical Characteristics of Infantile Hemangioma
 

Status: Recruiting

Condition Summary: Hemangioma

 

Last Updated: 31 Oct 2017

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Nadolol Versus Propranolol in Children With Infantile Hemangiomas
 

Status: Recruiting

Condition Summary: Infantile Hemangioma

 

Last Updated: 27 Apr 2018

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