Sickle cell hemoglobin C disease

Common Name(s)

Sickle cell hemoglobin C disease, Hemoglobin S/C disease

Hemoglobin S/C disease (Hb S/C) is a rare genetic condition. Hb S/C affects the number or shape of the red blood cells in the body. Normally, the red blood cells are round and donut-shaped. They bring the oxygen we breathe from our lungs to different parts of our body. Those with Hb S/C make some red blood cells that are crescent or sickle shaped rather than a round, donut shape. These unusually shaped cells do not last as long as normal red blood cells and die off. This can lead to anemia (a low number of red blood cells). The sickle or crescent shaped cells also tend to get stuck in blood vessels. When this happens, some parts of the body may not get enough blood. If red blood cells are not able to move through the blood vessels, parts of the body cannot get enough oxygen. Therefore, it is very important for our bodies to have an adequate number of red blood cells.

Those affected by Hb S/C may develop signs and symptoms a couple of months after birth. The characteristic features of this condition may include pale skin, sleeping longer or more often, tiredness, difficulty breathing, pain or swelling in the hands or feet, and cold hands or feet. If untreated, this disorder can lead to organ failure and death. Many of these complications can be prevented with early detection and lifelong management with appropriate medications, fluids, and blood transfusions. Many babies are screened for Hb S/C at birth so that treatment can begin early, however the conditions included in newborn screening differ from state to state. For more information, visit Baby’s First Test. Hb S/C is an autosomal recessive trait. A genetic counselor can help you understand the genetics. Also talk with your doctor and specialists to decide on the best treatment plan. Support groups are also a good source of information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Sickle cell hemoglobin C disease" for support, advocacy or research.

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American Sickle Cell Anemia Association

ASCAA is an organization that provides quality and comprehensive services through diagnostic testing, evaluation, couseling, and supportive services to individuals and families at-risk for sickle cell disease.

Last Updated: 1 Jun 2015

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Children's Sickle Cell Foundation, Inc.

The mission of the Children’s Sickle Cell Foundation, Inc. (CSCF) is to provide support for children with sickle cell disease (SCD) and their families to help them face the educational, social and economic challenges caused by the disease. Our commitment to sickle cell disease education and community outreach, and support for sickle cell disease research are natural extensions of this mission. CSCF is the sole provider of community based programs for children with SCD in Western Pennsylvania. Some of the programs offered by CSCF are the Educational Support and Learn2Swim.

Last Updated: 11 Mar 2016

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March of Dimes Foundation

Our mission is to improve the health of babies by preventing birth defects, premature birth, and infant mortality. We carry out this mission thorough research, community services, education and advocacy to save babies? lives.

Last Updated: 1 Jun 2015

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Sickle Cell Disease Association of America, Inc.

Our mission is to help improve the quality of life for persons/families affected by the sickle cell syndrome and related genetic disorders.

Last Updated: 1 Jun 2015

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Sickle Cell Society

Our vision is to be the most successful sickle cell organisation nationally with a wide network of well-informed, committed and active supporters working at local, national and international levels. We will be better able to empower and assist people with sickle cell disorders to achieve their full economic and social potential.

Last Updated: 23 Jun 2015

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Sickle Cell/Thalassemia Patients Network

SCTPN is dedicated to improving the quality of life for individuals and their families living with sickle cell disease, thalassemia, and other hemoglobin variants by providing services that will help to reduce the negative physical, emotional, educational, social, and economic impact of debilitating hemoglobinopathies.

Last Updated: 1 Jun 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Sickle cell hemoglobin C disease" for support, advocacy or research.

Logo
American Sickle Cell Anemia Association

ASCAA is an organization that provides quality and comprehensive services through diagnostic testing, evaluation, couseling, and supportive services to individuals and families at-risk for sickle cell disease.

http://www.ascaa.org

Last Updated: 1 Jun 2015

View Details
Children's Sickle Cell Foundation, Inc.

The mission of the Children’s Sickle Cell Foundation, Inc. (CSCF) is to provide support for children with sickle cell disease (SCD) and their families to help them face the educational, social and economic challenges caused by the disease. Our commitment to sickle cell disease education and community outreach, and support for sickle cell disease research are natural extensions of this mission. CSCF is the sole provider of community based programs for children with SCD in Western Pennsylvania. Some of the programs offered by CSCF are the Educational Support and Learn2Swim.

http://www.cscfkids.org

Last Updated: 11 Mar 2016

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March of Dimes Foundation

Our mission is to improve the health of babies by preventing birth defects, premature birth, and infant mortality. We carry out this mission thorough research, community services, education and advocacy to save babies? lives.

http://www.modimes.org

Last Updated: 1 Jun 2015

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Sickle Cell Disease Association of America, Inc.

Our mission is to help improve the quality of life for persons/families affected by the sickle cell syndrome and related genetic disorders.

http://www.sicklecelldisease.org/

Last Updated: 1 Jun 2015

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Sickle Cell Society

Our vision is to be the most successful sickle cell organisation nationally with a wide network of well-informed, committed and active supporters working at local, national and international levels. We will be better able to empower and assist people with sickle cell disorders to achieve their full economic and social potential.

http://www.sicklecellsociety.org/

Last Updated: 23 Jun 2015

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Sickle Cell/Thalassemia Patients Network

SCTPN is dedicated to improving the quality of life for individuals and their families living with sickle cell disease, thalassemia, and other hemoglobin variants by providing services that will help to reduce the negative physical, emotional, educational, social, and economic impact of debilitating hemoglobinopathies.

http://sctpn.org

Last Updated: 1 Jun 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Sickle cell hemoglobin C disease" returned 14 free, full-text research articles on human participants. First 3 results:

Red blood cell nitric oxide synthase activation is increased in patients with sickle cell hemoglobin C disease.
 

Author(s): Anaïs Mozar, Marijke Grau, Yann Lamarre, Linda Weyel, Frank Suhr, Bianca Collins, Marie-Dominique Hardy-Dessources, Marc Romana, Nathalie Lemonne, Maryse Etienne-Julan, Wilhelm Bloch, Philippe Connes

Journal: Am. J. Hematol.. 2015 Feb;90(2):E30-2.

 

Last Updated: 23 Jan 2015

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Impaired blood rheology plays a role in the chronic disorders associated with sickle cell-hemoglobin C disease.
 

Author(s): Nathalie Lemonne, Yann Lamarre, Marc Romana, Marie-Dominique Hardy-Dessources, François Lionnet, Xavier Waltz, Vanessa Tarer, Danielle Mougenel, Benot Tressières, Marie-Laure Lalanne-Mistrih, Maryse Etienne-Julan, Philippe Connes

Journal: Haematologica. 2014 May;99(5):74-5.

 

Last Updated: 5 May 2014

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Autoimmune haemolysis in unexpectedly mild sickle cell/hemoglobin C disease.
 

Author(s): Deena Iskander, Emma O'Donovan, Barbara J Bain

Journal: Am. J. Hematol.. 2013 Sep;88(9):817.

 

Last Updated: 21 Aug 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Sickle cell hemoglobin C disease" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Treatment of Adult Patients With Hemoglobin SC Disease (SCYTHE)
 

Status: Recruiting

Condition Summary: Hemoglobin SC Disease

 

Last Updated: 1 Dec 2016

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Treatment of Hemoglobin SC Disease
 

Status: Recruiting

Condition Summary: Hemoglobin SC Disease

 

Last Updated: 2 Aug 2016

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A Study of IMR-687 in Healthy Adult Volunteers
 

Status: Recruiting

Condition Summary: Sickle Cell Disease; Sickle-Cell; Hb-SC; Sickle Beta 0 Thalassemia

 

Last Updated: 15 Dec 2016

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