Hemoglobin SC disease

Common Name(s)

Hemoglobin SC disease

Hemoglobin SC disease is a common type of hemoglobinopathy, or hemoglobin disorder. Hemoglobin is a chemical found in the blood and its function is to carry oxygen from the lungs to the rest of the body. Hemoglobinopathies occur when there is a problem with this chemical and it is not able to function correctly. More specifically, hemoglobin SC disease is also a form of sickle cell disease, which is where the blood cells can change shape, or “sickle”, causing injury to the blood cells or clogging blood vessels. Hemoglobin SC disease may cause anemia (low blood cell counts), jaundice (yellowing of the skin), and enlargement of the spleen (an organ in the belly which works to filter blood). In infants, symptoms such as low energy, yellow eyes, orange-colored skin, and swollen hand and feet may be observed. This is a genetic disorder, meaning that it may be transferred from parents to their children. This condition often requires lifelong management, including frequent check-ups, different vitamins, and often medication.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hemoglobin SC disease" for support, advocacy or research.

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American Sickle Cell Anemia Association

ASCAA is an organization that provides quality and comprehensive services through diagnostic testing, evaluation, couseling, and supportive services to individuals and families at-risk for sickle cell disease.

Last Updated: 1 Jun 2015

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Sickle Cell Disease Foundation of California

To provide education and life-enhancing programs and services to individuals with sickle cell disease, to broaden public awareness about sickle cell disease and to promote medical research and education to ultimately find a cure.

Last Updated: 27 Mar 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Hemoglobin SC disease" for support, advocacy or research.

Logo
American Sickle Cell Anemia Association

ASCAA is an organization that provides quality and comprehensive services through diagnostic testing, evaluation, couseling, and supportive services to individuals and families at-risk for sickle cell disease.

http://www.ascaa.org

Last Updated: 1 Jun 2015

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Sickle Cell Disease Foundation of California

To provide education and life-enhancing programs and services to individuals with sickle cell disease, to broaden public awareness about sickle cell disease and to promote medical research and education to ultimately find a cure.

http://www.scdfc.org/

Last Updated: 27 Mar 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Hemoglobin SC disease" returned 24 free, full-text research articles on human participants. First 3 results:

Kidney Disease among Patients with Sickle Cell Disease, Hemoglobin SS and SC.
 

Author(s): Paul Drawz, Sabarish Ayyappan, Mehdi Nouraie, Santosh Saraf, Victor Gordeuk, Thomas Hostetter, Mark T Gladwin, Jane Little

Journal: Clin J Am Soc Nephrol. 2016 Feb;11(2):207-15.

 

Sickle cell disease (SCD) is an inherited anemia that afflicts millions worldwide. Kidney disease is a major contributor to its morbidity and mortality. We examined contemporary and historical SCD populations to understand how renal disease behaved in hemoglobin SS (HbSS) compared with HbSC.

Last Updated: 25 Feb 2016

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Effects of hydroxyurea treatment for patients with hemoglobin SC disease.
 

Author(s): Lori Luchtman-Jones, Sara Pressel, Lee Hilliard, R Clark Brown, Mary G Smith, Alexis A Thompson, Margaret T Lee, Jennifer Rothman, Zora R Rogers, William Owen, Hamayun Imran, Courtney Thornburg, Janet L Kwiatkowski, Banu Aygun, Stephen Nelson, Carla Roberts, Cynthia Gauger, Connie Piccone, Theodosia Kalfa, Ofelia Alvarez, Kathryn Hassell, Barry R Davis, Russell E Ware

Journal: Am. J. Hematol.. 2016 Feb;91(2):238-42.

 

Although hemoglobin SC (HbSC) disease is usually considered less severe than sickle cell anemia (SCA), which includes HbSS and HbS/β(0) -thalassemia genotypes, many patients with HbSC experience severe disease complications, including vaso-occlusive pain, acute chest syndrome, avascular ...

Last Updated: 23 Jan 2016

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Elevated hypercoagulability markers in hemoglobin SC disease.
 

Author(s): Marina P Colella, Erich V de Paula, João A Machado-Neto, Nicola Conran, Joyce M Annichino-Bizzacchi, Fernando F Costa, Sara T Olalla Saad, Fabiola Traina

Journal: Haematologica. 2015 Apr;100(4):466-71.

 

Hemoglobin SC disease is a very prevalent hemoglobinopathy; however, very little is known about this condition specifically. There appears to be an increased risk of thromboembolic events in hemoglobin SC disease, but studies evaluating the hemostatic alterations are lacking. We describe ...

Last Updated: 1 Apr 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Hemoglobin SC disease" returned 1 free, full-text review articles on human participants. First 3 results:

Role of phlebotomy in the management of hemoglobin SC disease: case report and review of the literature.
 

Author(s): Merry Jennifer Markham, Richard Lottenberg, Marc Zumberg

Journal: Am. J. Hematol.. 2003 Jun;73(2):121-5.

 

Marked variability is a keynote in the disease course of patients with hemoglobin SC (Hb SC) and hemoglobin S/beta(+)-thalassemia (Hb S/beta(+)-thal), with some patients having a frequency of complications and painful episodes similar to patients with homozygous sickle cell (Hb SS) ...

Last Updated: 15 May 2003

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Treatment of Adult Patients With Hemoglobin SC Disease (SCYTHE)
 

Status: Recruiting

Condition Summary: Hemoglobin SC Disease

 

Last Updated: 1 Dec 2016

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Treatment of Hemoglobin SC Disease
 

Status: Recruiting

Condition Summary: Hemoglobin SC Disease

 

Last Updated: 2 Aug 2016

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A Study of IMR-687 in Healthy Adult Volunteers
 

Status: Recruiting

Condition Summary: Sickle Cell Disease; Sickle-Cell; Hb-SC; Sickle Beta 0 Thalassemia

 

Last Updated: 15 Dec 2016

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